Home > Publications Database > Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies. > print

001     138377
005     20240826163725.0
024 7 _ |a 10.1093/brain/awv346
|2 doi
024 7 _ |a pmid:26647156
|2 pmid
024 7 _ |a pmc:PMC4805087
|2 pmc
024 7 _ |a 0006-8950
|2 ISSN
024 7 _ |a 1460-2156
|2 ISSN
024 7 _ |a altmetric:4852819
|2 altmetric
037 _ _ |a DZNE-2020-04699
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Stuendl, Anne
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.
260 _ _ |a Oxford
|c 2016
|b Oxford Univ. Press
264 _ 1 |3 online
|2 Crossref
|b Oxford University Press (OUP)
|c 2015-12-08
264 _ 1 |3 print
|2 Crossref
|b Oxford University Press (OUP)
|c 2016-02-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1724675667_21453
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Extracellular α-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular α-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal α-synuclein is present in the central nervous system in vivo. We hypothesized that exosomal α-synuclein species from patients with α-synuclein related neurodegeneration serve as carriers for interneuronal disease transmission. We isolated exosomes from cerebrospinal fluid from patients with Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy as a non-α-synuclein related disorder that clinically overlaps with Parkinson's disease, and neurological controls. Cerebrospinal fluid exosome numbers, α-synuclein protein content of cerebrospinal fluid exosomes and their potential to induce oligomerization of α-synuclein were analysed. The quantification of cerebrospinal fluid exosomal α-synuclein showed distinct differences between patients with Parkinson's disease and dementia with Lewy bodies. In addition, exosomal α-synuclein levels correlated with the severity of cognitive impairment in cross-sectional samples from patients with dementia with Lewy bodies. Importantly, cerebrospinal fluid exosomes derived from Parkinson's disease and dementia with Lewy bodies induce oligomerization of α-synuclein in a reporter cell line in a dose-dependent manner. Our data suggest that cerebrospinal fluid exosomes from patients with Parkinson's disease and dementia with Lewy bodies contain a pathogenic species of α-synuclein, which could initiate oligomerization of soluble α-synuclein in target cells and confer disease pathology.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Protein Aggregates
|2 NLM Chemicals
650 _ 7 |a alpha-Synuclein
|2 NLM Chemicals
650 _ 2 |a Cerebrospinal Fluid: metabolism
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Exosomes: metabolism
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Follow-Up Studies
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Lewy Body Disease: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Lewy Body Disease: metabolism
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Parkinson Disease: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Parkinson Disease: metabolism
|2 MeSH
650 _ 2 |a Protein Aggregates: physiology
|2 MeSH
650 _ 2 |a alpha-Synuclein: biosynthesis
|2 MeSH
650 _ 2 |a alpha-Synuclein: cerebrospinal fluid
|2 MeSH
700 1 _ |a Kunadt, Marcel
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Kruse, Niels
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Bartels, Claudia
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Moebius, Wiebke
|0 P:(DE-HGF)0
|b 4
700 1 _ |a Danzer, Karin M
|0 P:(DE-2719)9001513
|b 5
|u dzne
700 1 _ |a Mollenhauer, Brit
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Schneider, Anja
|0 P:(DE-2719)2812035
|b 7
|e Last author
773 1 8 |a 10.1093/brain/awv346
|b : Oxford University Press (OUP), 2015-12-08
|n 2
|p 481-494
|3 journal-article
|2 Crossref
|t Brain
|v 139
|y 2015
|x 0006-8950
773 _ _ |a 10.1093/brain/awv346
|g Vol. 139, no. Pt 2, p. 481 - 494
|0 PERI:(DE-600)1474117-9
|n 2
|q 139:Pt 2<481 - 494
|p 481-494
|t Brain
|v 139
|y 2016
|x 0006-8950
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/138377/files/DZNE-2020-04699.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/138377/files/DZNE-2020-04699.pdf?subformat=pdfa
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805087
909 C O |o oai:pub.dzne.de:138377
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 5
|6 P:(DE-2719)9001513
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 7
|6 P:(DE-2719)2812035
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2016
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a Creative Commons Attribution-NonCommercial CC BY-NC 4.0
|0 LIC:(DE-HGF)CCBYNC4
|2 HGFVOC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b BRAIN : 2017
915 _ _ |a IF >= 10
|0 StatID:(DE-HGF)9910
|2 StatID
|b BRAIN : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 1 _ |0 I:(DE-2719)1440011
|k AG Schneider Göttingen
|l Translational Dementia Research Göttingen
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1440011
980 1 _ |a FullTexts
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.nbd.2011.01.029
|2 Crossref
|o 10.1016/j.nbd.2011.01.029
999 C 5 |9 -- missing cx lookup --
|a 10.3389/fphys.2012.00124
|2 Crossref
|o 10.3389/fphys.2012.00124
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0197-4580(02)00065-9
|2 Crossref
|o 10.1016/S0197-4580(02)00065-9
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00702-002-0808-2
|2 Crossref
|o 10.1007/s00702-002-0808-2
999 C 5 |9 -- missing cx lookup --
|a 10.1186/1750-1326-7-42
|2 Crossref
|o 10.1186/1750-1326-7-42
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1471-4159.2009.06324.x
|2 Crossref
|o 10.1111/j.1471-4159.2009.06324.x
999 C 5 |9 -- missing cx lookup --
|a 10.1096/fj.10-164624
|2 Crossref
|o 10.1096/fj.10-164624
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0903691106
|2 Crossref
|o 10.1073/pnas.0903691106
999 C 5 |9 -- missing cx lookup --
|a 10.1096/fj.03-0098fje
|2 Crossref
|o 10.1096/fj.03-0098fje
999 C 5 |9 -- missing cx lookup --
|a 10.1096/fj.03-1449com
|2 Crossref
|o 10.1096/fj.03-1449com
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.addr.2012.08.008
|2 Crossref
|o 10.1016/j.addr.2012.08.008
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pone.0022225
|2 Crossref
|o 10.1371/journal.pone.0022225
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.5699-09.2010
|2 Crossref
|o 10.1523/JNEUROSCI.5699-09.2010
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pbio.0050158
|2 Crossref
|o 10.1371/journal.pbio.0050158
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.mcn.2005.12.003
|2 Crossref
|o 10.1016/j.mcn.2005.12.003
999 C 5 |9 -- missing cx lookup --
|a 10.1242/jcs.074088
|2 Crossref
|o 10.1242/jcs.074088
999 C 5 |9 -- missing cx lookup --
|a 10.3389/fphys.2012.00119
|2 Crossref
|o 10.3389/fphys.2012.00119
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pbio.1001604
|2 Crossref
|o 10.1371/journal.pbio.1001604
999 C 5 |9 -- missing cx lookup --
|a 10.3109/00207454.2014.961454
|2 Crossref
|o 10.3109/00207454.2014.961454
999 C 5 |9 -- missing cx lookup --
|a 10.1186/alzrt255
|2 Crossref
|o 10.1186/alzrt255
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awq008
|2 Crossref
|o 10.1093/brain/awq008
999 C 5 |y 2013
|2 Crossref
|o Kang 2013
999 C 5 |9 -- missing cx lookup --
|a 10.1038/npp.2008.161
|2 Crossref
|o 10.1038/npp.2008.161
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.expneurol.2009.09.016
|2 Crossref
|o 10.1016/j.expneurol.2009.09.016
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.ymeth.2012.03.016
|2 Crossref
|o 10.1016/j.ymeth.2012.03.016
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00401-015-1408-1
|2 Crossref
|o 10.1007/s00401-015-1408-1
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nrneurol.2013.275
|2 Crossref
|o 10.1038/nrneurol.2013.275
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.0692-05.2005
|2 Crossref
|o 10.1523/JNEUROSCI.0692-05.2005
999 C 5 |9 -- missing cx lookup --
|a 10.1007/978-1-61779-551-0_23
|2 Crossref
|o 10.1007/978-1-61779-551-0_23
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nm1746
|2 Crossref
|o 10.1038/nm1746
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.23012
|2 Crossref
|o 10.1002/mds.23012
999 C 5 |9 -- missing cx lookup --
|a 10.1212/01.wnl.0000256715.13907.d3
|2 Crossref
|o 10.1212/01.wnl.0000256715.13907.d3
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.47.1.1
|2 Crossref
|o 10.1212/WNL.47.1.1
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.1227157
|2 Crossref
|o 10.1126/science.1227157
999 C 5 |9 -- missing cx lookup --
|a 10.1084/jem.20112457
|2 Crossref
|o 10.1084/jem.20112457
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.ymeth.2003.10.010
|2 Crossref
|o 10.1016/j.ymeth.2003.10.010
999 C 5 |9 -- missing cx lookup --
|a 10.1186/1750-1326-5-12
|2 Crossref
|o 10.1186/1750-1326-5-12
999 C 5 |9 -- missing cx lookup --
|a 10.1212/01.wnl.0000187889.17253.b1
|2 Crossref
|o 10.1212/01.wnl.0000187889.17253.b1
999 C 5 |9 -- missing cx lookup --
|a 10.1159/000083178
|2 Crossref
|o 10.1159/000083178
999 C 5 |9 -- missing cx lookup --
|a 10.2217/bmm.10.90
|2 Crossref
|o 10.2217/bmm.10.90
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S1474-4422(11)70014-X
|2 Crossref
|o 10.1016/S1474-4422(11)70014-X
999 C 5 |9 -- missing cx lookup --
|a 10.1136/jnnp.2010.206391
|2 Crossref
|o 10.1136/jnnp.2010.206391
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00702-012-0784-0
|2 Crossref
|o 10.1007/s00702-012-0784-0
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.0b013e3182a6cbd5
|2 Crossref
|o 10.1212/WNL.0b013e3182a6cbd5
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neulet.2012.11.004
|2 Crossref
|o 10.1016/j.neulet.2012.11.004
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.23287
|2 Crossref
|o 10.1002/mds.23287
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neurobiolaging.2011.06.022
|2 Crossref
|o 10.1016/j.neurobiolaging.2011.06.022
999 C 5 |9 -- missing cx lookup --
|a 10.1097/01.jnen.0000171652.40083.15
|2 Crossref
|o 10.1097/01.jnen.0000171652.40083.15
999 C 5 |9 -- missing cx lookup --
|a 10.1097/WCO.0b013e32835a30f4
|2 Crossref
|o 10.1097/WCO.0b013e32835a30f4
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.brainres.2008.11.055
|2 Crossref
|o 10.1016/j.brainres.2008.11.055
999 C 5 |9 -- missing cx lookup --
|a 10.1074/jbc.M110.148460
|2 Crossref
|o 10.1074/jbc.M110.148460
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neulet.2008.11.015
|2 Crossref
|o 10.1016/j.neulet.2008.11.015
999 C 5 |9 -- missing cx lookup --
|a 10.1113/jphysiol.2013.264069
|2 Crossref
|o 10.1113/jphysiol.2013.264069
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pone.0001867
|2 Crossref
|o 10.1371/journal.pone.0001867
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.jns.2009.02.321
|2 Crossref
|o 10.1016/j.jns.2009.02.321
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.25945
|2 Crossref
|o 10.1002/mds.25945
999 C 5 |9 -- missing cx lookup --
|a 10.3233/JAD-2010-100186
|2 Crossref
|o 10.3233/JAD-2010-100186
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00441-012-1428-2
|2 Crossref
|o 10.1007/s00441-012-1428-2
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00401-014-1314-y
|2 Crossref
|o 10.1007/s00401-014-1314-y
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.colsurfb.2011.05.013
|2 Crossref
|o 10.1016/j.colsurfb.2011.05.013
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.95.11.6469
|2 Crossref
|o 10.1073/pnas.95.11.6469
999 C 5 |9 -- missing cx lookup --
|a 10.1074/jbc.M110.134775
|2 Crossref
|o 10.1074/jbc.M110.134775
999 C 5 |9 -- missing cx lookup --
|a 10.1002/gps.4274
|2 Crossref
|o 10.1002/gps.4274
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.0b013e3181fd613b
|2 Crossref
|o 10.1212/WNL.0b013e3181fd613b
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.bbrc.2006.08.024
|2 Crossref
|o 10.1016/j.bbrc.2006.08.024
999 C 5 |9 -- missing cx lookup --
|a 10.1002/emmm.201201823
|2 Crossref
|o 10.1002/emmm.201201823
999 C 5 |9 -- missing cx lookup --
|a 10.1111/jth.12602
|2 Crossref
|o 10.1111/jth.12602
999 C 5 |y 1997
|2 Crossref
|o Vidal 1997
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2011.08.033
|2 Crossref
|o 10.1016/j.neuron.2011.08.033
999 C 5 |9 -- missing cx lookup --
|a 10.1038/mt.2011.164
|2 Crossref
|o 10.1038/mt.2011.164

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21