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000138400 0247_ $$2doi$$a10.1016/j.neurobiolaging.2015.11.022
000138400 0247_ $$2pmid$$apmid:26923402
000138400 0247_ $$2ISSN$$a0197-4580
000138400 0247_ $$2ISSN$$a1558-1497
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000138400 037__ $$aDZNE-2020-04722
000138400 041__ $$aEnglish
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000138400 1001_ $$0P:(DE-HGF)0$$aRosenbaum, David$$b0$$eCorresponding author
000138400 245__ $$aState-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study.
000138400 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2016
000138400 264_1 $$2Crossref$$3print$$bElsevier BV$$c2016-03-01
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000138400 520__ $$aThere is a large body of evidence showing a substantial relationship between depression and deficits in cognitive functioning. Especially in late-life depression, cognitive impairments are associated with worse treatment progress and are considered a risk factor for neurodegenerative disorders. However, little is known about the differences in neural processing and coupling during rest and cognitive functions in patients with late-life depression compared to healthy elderly individuals. The study at hand aims to investigate the cognitive control network in late-life depression during a cognitive task and at rest by means of functional near-infrared spectroscopy. Hemodynamic responses were measured at rest and during the Trail Making Test using functional near-infrared spectroscopy in a matched sample of 49 depressed and 51 nondepressed elderly subjects (age range: 51-83 years; 64.1 ± 6.58 [mean ± standard deviation]). Functional connectivity (FC) and network metrics were derived from the data and analyzed with respect to differences between the subject groups. Depressed and nondepressed subjects showed significant differences in FC both at rest and during task performance. Depressed subjects showed reduced FC in a left frontopolar cortical network during task performance and increased FC in a left frontoparietal cortical network at rest. Depressed elderly subjects showed altered FC and network organization during different mental states. Higher FC at rest may be an indicator of self-referential processes such as rumination that may reduce FC during task performance due to an overtaxed executive control system.
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000138400 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x1
000138400 542__ $$2Crossref$$i2016-03-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
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000138400 650_2 $$2MeSH$$aAged
000138400 650_2 $$2MeSH$$aAged, 80 and over
000138400 650_2 $$2MeSH$$aCognition
000138400 650_2 $$2MeSH$$aDepression: complications
000138400 650_2 $$2MeSH$$aDepression: physiopathology
000138400 650_2 $$2MeSH$$aDepression: psychology
000138400 650_2 $$2MeSH$$aDisease Progression
000138400 650_2 $$2MeSH$$aExecutive Function
000138400 650_2 $$2MeSH$$aFemale
000138400 650_2 $$2MeSH$$aHemodynamics
000138400 650_2 $$2MeSH$$aHumans
000138400 650_2 $$2MeSH$$aLate Onset Disorders
000138400 650_2 $$2MeSH$$aMale
000138400 650_2 $$2MeSH$$aMiddle Aged
000138400 650_2 $$2MeSH$$aNerve Net: physiopathology
000138400 650_2 $$2MeSH$$aNeurodegenerative Diseases: etiology
000138400 650_2 $$2MeSH$$aPsychomotor Performance
000138400 650_2 $$2MeSH$$aRest: physiology
000138400 650_2 $$2MeSH$$aRisk Factors
000138400 650_2 $$2MeSH$$aSpectroscopy, Near-Infrared
000138400 7001_ $$0P:(DE-2719)2801322$$aHagen, Katja$$b1$$udzne
000138400 7001_ $$0P:(DE-HGF)0$$aDeppermann, Saskia$$b2
000138400 7001_ $$0P:(DE-HGF)0$$aKroczek, Agnes M$$b3
000138400 7001_ $$0P:(DE-HGF)0$$aHaeussinger, Florian B$$b4
000138400 7001_ $$0P:(DE-HGF)0$$aHeinzel, Sebastian$$b5
000138400 7001_ $$0P:(DE-2719)2000059$$aBerg, Daniela$$b6$$udzne
000138400 7001_ $$0P:(DE-HGF)0$$aFallgatter, Andreas J$$b7
000138400 7001_ $$0P:(DE-HGF)0$$aMetzger, Florian G$$b8
000138400 7001_ $$0P:(DE-HGF)0$$aEhlis, Ann-Christine$$b9
000138400 7001_ $$0P:(DE-HGF)0$$aConsortium, TREND Study$$b10
000138400 77318 $$2Crossref$$3journal-article$$a10.1016/j.neurobiolaging.2015.11.022$$b : Elsevier BV, 2016-03-01$$p57-68$$tNeurobiology of Aging$$v39$$x0197-4580$$y2016
000138400 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2015.11.022$$gVol. 39, p. 57 - 68$$p57-68$$q39<57 - 68$$tNeurobiology of aging$$v39$$x0197-4580$$y2016
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