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@ARTICLE{Rosenbaum:138400,
      author       = {Rosenbaum, David and Hagen, Katja and Deppermann, Saskia
                      and Kroczek, Agnes M and Haeussinger, Florian B and Heinzel,
                      Sebastian and Berg, Daniela and Fallgatter, Andreas J and
                      Metzger, Florian G and Ehlis, Ann-Christine and Consortium,
                      TREND Study},
      title        = {{S}tate-dependent altered connectivity in late-life
                      depression: a functional near-infrared spectroscopy study.},
      journal      = {Neurobiology of aging},
      volume       = {39},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-04722},
      pages        = {57-68},
      year         = {2016},
      abstract     = {There is a large body of evidence showing a substantial
                      relationship between depression and deficits in cognitive
                      functioning. Especially in late-life depression, cognitive
                      impairments are associated with worse treatment progress and
                      are considered a risk factor for neurodegenerative
                      disorders. However, little is known about the differences in
                      neural processing and coupling during rest and cognitive
                      functions in patients with late-life depression compared to
                      healthy elderly individuals. The study at hand aims to
                      investigate the cognitive control network in late-life
                      depression during a cognitive task and at rest by means of
                      functional near-infrared spectroscopy. Hemodynamic responses
                      were measured at rest and during the Trail Making Test using
                      functional near-infrared spectroscopy in a matched sample of
                      49 depressed and 51 nondepressed elderly subjects (age
                      range: 51-83 years; 64.1 ± 6.58 [mean ± standard
                      deviation]). Functional connectivity (FC) and network
                      metrics were derived from the data and analyzed with respect
                      to differences between the subject groups. Depressed and
                      nondepressed subjects showed significant differences in FC
                      both at rest and during task performance. Depressed subjects
                      showed reduced FC in a left frontopolar cortical network
                      during task performance and increased FC in a left
                      frontoparietal cortical network at rest. Depressed elderly
                      subjects showed altered FC and network organization during
                      different mental states. Higher FC at rest may be an
                      indicator of self-referential processes such as rumination
                      that may reduce FC during task performance due to an
                      overtaxed executive control system.},
      keywords     = {Aged / Aged, 80 and over / Cognition / Depression:
                      complications / Depression: physiopathology / Depression:
                      psychology / Disease Progression / Executive Function /
                      Female / Hemodynamics / Humans / Late Onset Disorders / Male
                      / Middle Aged / Nerve Net: physiopathology /
                      Neurodegenerative Diseases: etiology / Psychomotor
                      Performance / Rest: physiology / Risk Factors /
                      Spectroscopy, Near-Infrared},
      cin          = {AG N.N. 3 / AG Berg ; AG Berg},
      ddc          = {610},
      cid          = {I:(DE-2719)1240015 / I:(DE-2719)5000055},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26923402},
      doi          = {10.1016/j.neurobiolaging.2015.11.022},
      url          = {https://pub.dzne.de/record/138400},
}