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024 7 _ |a 10.1016/j.neurobiolaging.2015.11.022
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024 7 _ |a pmid:26923402
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024 7 _ |a 0197-4580
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024 7 _ |a 1558-1497
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024 7 _ |a altmetric:4846506
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037 _ _ |a DZNE-2020-04722
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Rosenbaum, David
|0 P:(DE-HGF)0
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|e Corresponding author
245 _ _ |a State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study.
260 _ _ |a Amsterdam [u.a.]
|c 2016
|b Elsevier Science
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2016-03-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a There is a large body of evidence showing a substantial relationship between depression and deficits in cognitive functioning. Especially in late-life depression, cognitive impairments are associated with worse treatment progress and are considered a risk factor for neurodegenerative disorders. However, little is known about the differences in neural processing and coupling during rest and cognitive functions in patients with late-life depression compared to healthy elderly individuals. The study at hand aims to investigate the cognitive control network in late-life depression during a cognitive task and at rest by means of functional near-infrared spectroscopy. Hemodynamic responses were measured at rest and during the Trail Making Test using functional near-infrared spectroscopy in a matched sample of 49 depressed and 51 nondepressed elderly subjects (age range: 51-83 years; 64.1 ± 6.58 [mean ± standard deviation]). Functional connectivity (FC) and network metrics were derived from the data and analyzed with respect to differences between the subject groups. Depressed and nondepressed subjects showed significant differences in FC both at rest and during task performance. Depressed subjects showed reduced FC in a left frontopolar cortical network during task performance and increased FC in a left frontoparietal cortical network at rest. Depressed elderly subjects showed altered FC and network organization during different mental states. Higher FC at rest may be an indicator of self-referential processes such as rumination that may reduce FC during task performance due to an overtaxed executive control system.
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542 _ _ |i 2016-03-01
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650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Depression: complications
|2 MeSH
650 _ 2 |a Depression: physiopathology
|2 MeSH
650 _ 2 |a Depression: psychology
|2 MeSH
650 _ 2 |a Disease Progression
|2 MeSH
650 _ 2 |a Executive Function
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Hemodynamics
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Late Onset Disorders
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Nerve Net: physiopathology
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: etiology
|2 MeSH
650 _ 2 |a Psychomotor Performance
|2 MeSH
650 _ 2 |a Rest: physiology
|2 MeSH
650 _ 2 |a Risk Factors
|2 MeSH
650 _ 2 |a Spectroscopy, Near-Infrared
|2 MeSH
700 1 _ |a Hagen, Katja
|0 P:(DE-2719)2801322
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700 1 _ |a Deppermann, Saskia
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700 1 _ |a Kroczek, Agnes M
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700 1 _ |a Haeussinger, Florian B
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700 1 _ |a Heinzel, Sebastian
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700 1 _ |a Berg, Daniela
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700 1 _ |a Fallgatter, Andreas J
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700 1 _ |a Metzger, Florian G
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700 1 _ |a Ehlis, Ann-Christine
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700 1 _ |a Consortium, TREND Study
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773 1 8 |a 10.1016/j.neurobiolaging.2015.11.022
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|t Neurobiology of Aging
|v 39
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773 _ _ |a 10.1016/j.neurobiolaging.2015.11.022
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|v 39
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