TY  - JOUR
AU  - Düzel, Emrah
AU  - van Praag, Henriette
AU  - Sendtner, Michael
TI  - Can physical exercise in old age improve memory and hippocampal function?
JO  - Brain
VL  - 139
IS  - 3
SN  - 0006-8950
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2020-04748
SP  - 662-673
PY  - 2016
AB  - Physical exercise can convey a protective effect against cognitive decline in ageing and Alzheimer's disease. While the long-term health-promoting and protective effects of exercise are encouraging, it's potential to induce neuronal and vascular plasticity in the ageing brain is still poorly understood. It remains unclear whether exercise slows the trajectory of normal ageing by modifying vascular and metabolic risk factors and/or consistently boosts brain function by inducing structural and neurochemical changes in the hippocampus and related medial temporal lobe circuitry-brain areas that are important for learning and memory. Hence, it remains to be established to what extent exercise interventions in old age can improve brain plasticity above and beyond preservation of function. Existing data suggest that exercise trials aiming for improvement and preservation may require different outcome measures and that the balance between the two may depend on exercise intensity and duration, the presence of preclinical Alzheimer's disease pathology, vascular and metabolic risk factors and genetic variability.
KW  - Aging: physiology
KW  - Aging: psychology
KW  - Alzheimer Disease: diagnosis
KW  - Alzheimer Disease: prevention & control
KW  - Animals
KW  - Exercise: physiology
KW  - Hippocampus: physiology
KW  - Humans
KW  - Memory: physiology
KW  - Memory Disorders: diagnosis
KW  - Memory Disorders: therapy
KW  - Neuronal Plasticity: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:26912638
C2  - pmc:PMC4766381
DO  - DOI:10.1093/brain/awv407
UR  - https://pub.dzne.de/record/138426
ER  -