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@ARTICLE{Dzel:138426,
      author       = {Düzel, Emrah and van Praag, Henriette and Sendtner,
                      Michael},
      title        = {{C}an physical exercise in old age improve memory and
                      hippocampal function?},
      journal      = {Brain},
      volume       = {139},
      number       = {3},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2020-04748},
      pages        = {662-673},
      year         = {2016},
      abstract     = {Physical exercise can convey a protective effect against
                      cognitive decline in ageing and Alzheimer's disease. While
                      the long-term health-promoting and protective effects of
                      exercise are encouraging, it's potential to induce neuronal
                      and vascular plasticity in the ageing brain is still poorly
                      understood. It remains unclear whether exercise slows the
                      trajectory of normal ageing by modifying vascular and
                      metabolic risk factors and/or consistently boosts brain
                      function by inducing structural and neurochemical changes in
                      the hippocampus and related medial temporal lobe
                      circuitry-brain areas that are important for learning and
                      memory. Hence, it remains to be established to what extent
                      exercise interventions in old age can improve brain
                      plasticity above and beyond preservation of function.
                      Existing data suggest that exercise trials aiming for
                      improvement and preservation may require different outcome
                      measures and that the balance between the two may depend on
                      exercise intensity and duration, the presence of preclinical
                      Alzheimer's disease pathology, vascular and metabolic risk
                      factors and genetic variability.},
      keywords     = {Aging: physiology / Aging: psychology / Alzheimer Disease:
                      diagnosis / Alzheimer Disease: prevention $\&$ control /
                      Animals / Exercise: physiology / Hippocampus: physiology /
                      Humans / Memory: physiology / Memory Disorders: diagnosis /
                      Memory Disorders: therapy / Neuronal Plasticity: physiology},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26912638},
      pmc          = {pmc:PMC4766381},
      doi          = {10.1093/brain/awv407},
      url          = {https://pub.dzne.de/record/138426},
}