Home > Publications Database > Can physical exercise in old age improve memory and hippocampal function? > print

001     138426
005     20240321220431.0
024 7 _ |a 10.1093/brain/awv407
|2 doi
024 7 _ |a pmid:26912638
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024 7 _ |a pmc:PMC4766381
|2 pmc
024 7 _ |a 0006-8950
|2 ISSN
024 7 _ |a 1460-2156
|2 ISSN
024 7 _ |a altmetric:5516668
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037 _ _ |a DZNE-2020-04748
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Düzel, Emrah
|0 P:(DE-2719)2000005
|b 0
|e First author
245 _ _ |a Can physical exercise in old age improve memory and hippocampal function?
260 _ _ |a Oxford
|c 2016
|b Oxford Univ. Press
264 _ 1 |3 online
|2 Crossref
|b Oxford University Press (OUP)
|c 2016-02-11
264 _ 1 |3 print
|2 Crossref
|b Oxford University Press (OUP)
|c 2016-03-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Physical exercise can convey a protective effect against cognitive decline in ageing and Alzheimer's disease. While the long-term health-promoting and protective effects of exercise are encouraging, it's potential to induce neuronal and vascular plasticity in the ageing brain is still poorly understood. It remains unclear whether exercise slows the trajectory of normal ageing by modifying vascular and metabolic risk factors and/or consistently boosts brain function by inducing structural and neurochemical changes in the hippocampus and related medial temporal lobe circuitry-brain areas that are important for learning and memory. Hence, it remains to be established to what extent exercise interventions in old age can improve brain plasticity above and beyond preservation of function. Existing data suggest that exercise trials aiming for improvement and preservation may require different outcome measures and that the balance between the two may depend on exercise intensity and duration, the presence of preclinical Alzheimer's disease pathology, vascular and metabolic risk factors and genetic variability.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Aging: psychology
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnosis
|2 MeSH
650 _ 2 |a Alzheimer Disease: prevention & control
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Exercise: physiology
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Memory: physiology
|2 MeSH
650 _ 2 |a Memory Disorders: diagnosis
|2 MeSH
650 _ 2 |a Memory Disorders: therapy
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
700 1 _ |a van Praag, Henriette
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Sendtner, Michael
|0 P:(DE-HGF)0
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773 1 8 |a 10.1093/brain/awv407
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|n 3
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|t Brain
|v 139
|y 2016
|x 0006-8950
773 _ _ |a 10.1093/brain/awv407
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856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766381
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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914 1 _ |y 2016
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21