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000138469 0247_ $$2doi$$a10.1002/hipo.22502
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000138469 037__ $$aDZNE-2020-04791
000138469 041__ $$aEnglish
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000138469 1001_ $$0P:(DE-HGF)0$$aCraig, Michael$$b0$$eCorresponding author
000138469 245__ $$aWakeful rest promotes the integration of spatial memories into accurate cognitive maps.
000138469 260__ $$aNew York, NY [u.a.]$$bWiley$$c2016
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000138469 520__ $$aFlexible spatial navigation, e.g. the ability to take novel shortcuts, is contingent upon accurate mental representations of environments-cognitive maps. These cognitive maps critically depend on hippocampal place cells. In rodents, place cells replay recently travelled routes, especially during periods of behavioural inactivity (sleep/wakeful rest). This neural replay is hypothesised to promote not only the consolidation of specific experiences, but also their wider integration, e.g. into accurate cognitive maps. In humans, rest promotes the consolidation of specific experiences, but the effect of rest on the wider integration of memories remained unknown. In the present study, we examined the hypothesis that cognitive map formation is supported by rest-related integration of new spatial memories. We predicted that if wakeful rest supports cognitive map formation, then rest should enhance knowledge of overarching spatial relations that were never experienced directly during recent navigation. Forty young participants learned a route through a virtual environment before either resting wakefully or engaging in an unrelated perceptual task for 10 min. Participants in the wakeful rest condition performed more accurately in a delayed cognitive map test, requiring the pointing to landmarks from a range of locations. Importantly, the benefit of rest could not be explained by active rehearsal, but can be attributed to the promotion of consolidation-related activity. These findings (i) resonate with the demonstration of hippocampal replay in rodents, and (ii) provide the first evidence that wakeful rest can improve the integration of new spatial memories in humans, a function that has, hitherto, been associated with sleep.
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000138469 650_2 $$2MeSH$$aCognition: physiology
000138469 650_2 $$2MeSH$$aFemale
000138469 650_2 $$2MeSH$$aHumans
000138469 650_2 $$2MeSH$$aMale
000138469 650_2 $$2MeSH$$aPhotic Stimulation: methods
000138469 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000138469 650_2 $$2MeSH$$aReaction Time: physiology
000138469 650_2 $$2MeSH$$aRest: physiology
000138469 650_2 $$2MeSH$$aSpatial Memory: physiology
000138469 650_2 $$2MeSH$$aSpatial Navigation: physiology
000138469 650_2 $$2MeSH$$aWakefulness: physiology
000138469 650_2 $$2MeSH$$aYoung Adult
000138469 7001_ $$0P:(DE-HGF)0$$aDewar, Michaela$$b1
000138469 7001_ $$0P:(DE-HGF)0$$aHarris, Mathew A$$b2
000138469 7001_ $$0P:(DE-HGF)0$$aDella Sala, Sergio$$b3
000138469 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b4$$eLast author
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