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@ARTICLE{Craig:138469,
      author       = {Craig, Michael and Dewar, Michaela and Harris, Mathew A and
                      Della Sala, Sergio and Wolbers, Thomas},
      title        = {{W}akeful rest promotes the integration of spatial memories
                      into accurate cognitive maps.},
      journal      = {Hippocampus},
      volume       = {26},
      number       = {2},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-04791},
      pages        = {185-193},
      year         = {2016},
      abstract     = {Flexible spatial navigation, e.g. the ability to take novel
                      shortcuts, is contingent upon accurate mental
                      representations of environments-cognitive maps. These
                      cognitive maps critically depend on hippocampal place cells.
                      In rodents, place cells replay recently travelled routes,
                      especially during periods of behavioural inactivity
                      (sleep/wakeful rest). This neural replay is hypothesised to
                      promote not only the consolidation of specific experiences,
                      but also their wider integration, e.g. into accurate
                      cognitive maps. In humans, rest promotes the consolidation
                      of specific experiences, but the effect of rest on the wider
                      integration of memories remained unknown. In the present
                      study, we examined the hypothesis that cognitive map
                      formation is supported by rest-related integration of new
                      spatial memories. We predicted that if wakeful rest supports
                      cognitive map formation, then rest should enhance knowledge
                      of overarching spatial relations that were never experienced
                      directly during recent navigation. Forty young participants
                      learned a route through a virtual environment before either
                      resting wakefully or engaging in an unrelated perceptual
                      task for 10 min. Participants in the wakeful rest condition
                      performed more accurately in a delayed cognitive map test,
                      requiring the pointing to landmarks from a range of
                      locations. Importantly, the benefit of rest could not be
                      explained by active rehearsal, but can be attributed to the
                      promotion of consolidation-related activity. These findings
                      (i) resonate with the demonstration of hippocampal replay in
                      rodents, and (ii) provide the first evidence that wakeful
                      rest can improve the integration of new spatial memories in
                      humans, a function that has, hitherto, been associated with
                      sleep.},
      keywords     = {Cognition: physiology / Female / Humans / Male / Photic
                      Stimulation: methods / Psychomotor Performance: physiology /
                      Reaction Time: physiology / Rest: physiology / Spatial
                      Memory: physiology / Spatial Navigation: physiology /
                      Wakefulness: physiology / Young Adult},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26235141},
      doi          = {10.1002/hipo.22502},
      url          = {https://pub.dzne.de/record/138469},
}