000138493 001__ 138493 000138493 005__ 20240525120341.0 000138493 0247_ $$2doi$$a10.7554/eLife.07886 000138493 0247_ $$2pmid$$apmid:26308582 000138493 0247_ $$2pmc$$apmc:PMC4579288 000138493 0247_ $$2altmetric$$aaltmetric:4443217 000138493 037__ $$aDZNE-2020-04815 000138493 041__ $$aEnglish 000138493 082__ $$a600 000138493 1001_ $$0P:(DE-HGF)0$$aWatrous, Andrew J$$b0$$eCorresponding author 000138493 245__ $$aPhase-amplitude coupling supports phase coding in human ECoG. 000138493 260__ $$aCambridge$$beLife Sciences Publications$$c2015 000138493 264_1 $$2Crossref$$3online$$beLife Sciences Publications, Ltd$$c2015-08-26 000138493 3367_ $$2DRIVER$$aarticle 000138493 3367_ $$2DataCite$$aOutput Types/Journal article 000138493 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1716553310_5216 000138493 3367_ $$2BibTeX$$aARTICLE 000138493 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000138493 3367_ $$00$$2EndNote$$aJournal Article 000138493 520__ $$aPrior studies have shown that high-frequency activity (HFA) is modulated by the phase of low-frequency activity. This phenomenon of phase-amplitude coupling (PAC) is often interpreted as reflecting phase coding of neural representations, although evidence for this link is still lacking in humans. Here, we show that PAC indeed supports phase-dependent stimulus representations for categories. Six patients with medication-resistant epilepsy viewed images of faces, tools, houses, and scenes during simultaneous acquisition of intracranial recordings. Analyzing 167 electrodes, we observed PAC at 43% of electrodes. Further inspection of PAC revealed that category specific HFA modulations occurred at different phases and frequencies of the underlying low-frequency rhythm, permitting decoding of categorical information using the phase at which HFA events occurred. These results provide evidence for categorical phase-coded neural representations and are the first to show that PAC coincides with phase-dependent coding in the human brain. 000138493 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0 000138493 542__ $$2Crossref$$i2015-08-26$$uhttp://creativecommons.org/licenses/by/4.0/ 000138493 588__ $$aDataset connected to CrossRef, PubMed, 000138493 650_2 $$2MeSH$$aBrain: physiology 000138493 650_2 $$2MeSH$$aBrain Waves 000138493 650_2 $$2MeSH$$aDrug Resistant Epilepsy: physiopathology 000138493 650_2 $$2MeSH$$aElectrocorticography 000138493 650_2 $$2MeSH$$aHumans 000138493 650_2 $$2MeSH$$aPhotic Stimulation 000138493 7001_ $$aDeuker, Lorena$$b1 000138493 7001_ $$aFell, Juergen$$b2 000138493 7001_ $$0P:(DE-2719)2000052$$aAxmacher, Nikolai$$b3$$eLast author$$udzne 000138493 77318 $$2Crossref$$3journal-article$$a10.7554/elife.07886$$b : eLife Sciences Publications, Ltd, 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