TY - JOUR AU - Watrous, Andrew J AU - Deuker, Lorena AU - Fell, Juergen AU - Axmacher, Nikolai TI - Phase-amplitude coupling supports phase coding in human ECoG. JO - eLife VL - 4 SN - 2050-084X CY - Cambridge PB - eLife Sciences Publications M1 - DZNE-2020-04815 SP - e07886 PY - 2015 AB - Prior studies have shown that high-frequency activity (HFA) is modulated by the phase of low-frequency activity. This phenomenon of phase-amplitude coupling (PAC) is often interpreted as reflecting phase coding of neural representations, although evidence for this link is still lacking in humans. Here, we show that PAC indeed supports phase-dependent stimulus representations for categories. Six patients with medication-resistant epilepsy viewed images of faces, tools, houses, and scenes during simultaneous acquisition of intracranial recordings. Analyzing 167 electrodes, we observed PAC at 43 KW - Brain: physiology KW - Brain Waves KW - Drug Resistant Epilepsy: physiopathology KW - Electrocorticography KW - Humans KW - Photic Stimulation LB - PUB:(DE-HGF)16 C6 - pmid:26308582 C2 - pmc:PMC4579288 DO - DOI:10.7554/eLife.07886 UR - https://pub.dzne.de/record/138493 ER -