%0 Journal Article
%A Schüle, Rebecca
%A Wiethoff, Sarah
%A Martus, Peter
%A Karle, Kathrin N
%A Otto, Susanne
%A Klebe, Stephan
%A Klimpe, Sven
%A Gallenmüller, Constanze
%A Kurzwelly, Delia
%A Henkel, Dorothea
%A Rimmele, Florian
%A Stolze, Henning
%A Kohl, Zacharias
%A Kassubek, Jan
%A Klockgether, Thomas
%A Vielhaber, Stefan
%A Kamm, Christoph
%A Klopstock, Thomas
%A Bauer, Peter
%A Züchner, Stephan
%A Liepelt-Scarfone, Inga
%A Schöls, Ludger
%T Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients.
%J Annals of neurology
%V 79
%N 4
%@ 0364-5134
%C Hoboken, NJ
%I Wiley-Blackwell
%M DZNE-2020-04820
%P 646-658
%D 2016
%X Hereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. To investigate the phenotypic spectrum, prognostic factors, and genotype-specific differences, we analyzed baseline data from a continuous, prospective cohort.We recruited 608 HSP cases from 519 families of mostly German origin. Clinical severity was assessed by the Spastic Paraplegia Rating Scale. Complicating symptoms were recorded by a standardized inventory.Family history indicated dominant (43
%K Adult
%K Aged
%K Cross-Sectional Studies
%K Female
%K Germany: epidemiology
%K Humans
%K Male
%K Middle Aged
%K Pedigree
%K Severity of Illness Index
%K Spastic Paraplegia, Hereditary: epidemiology
%K Spastic Paraplegia, Hereditary: genetics
%K Spastic Paraplegia, Hereditary: physiopathology
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26856398
%R 10.1002/ana.24611
%U https://pub.dzne.de/record/138498