000138523 001__ 138523
000138523 005__ 20240321220445.0
000138523 0247_ $$2doi$$a10.1016/j.neuroimage.2015.10.084
000138523 0247_ $$2pmid$$apmid:26545456
000138523 0247_ $$2ISSN$$a1053-8119
000138523 0247_ $$2ISSN$$a1095-9572
000138523 0247_ $$2altmetric$$aaltmetric:4738094
000138523 037__ $$aDZNE-2020-04845
000138523 041__ $$aEnglish
000138523 082__ $$a610
000138523 1001_ $$0P:(DE-2719)2811815$$aMaaß, Anne$$b0$$eFirst author$$udzne
000138523 245__ $$aRelationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults.
000138523 260__ $$aOrlando, Fla.$$bAcademic Press$$c2016
000138523 264_1 $$2Crossref$$3print$$bElsevier BV$$c2016-05-01
000138523 3367_ $$2DRIVER$$aarticle
000138523 3367_ $$2DataCite$$aOutput Types/Journal article
000138523 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1709719217_11499
000138523 3367_ $$2BibTeX$$aARTICLE
000138523 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000138523 3367_ $$00$$2EndNote$$aJournal Article
000138523 520__ $$aAnimal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating exercise-induced structural and functional changes in the hippocampus. Recently, also platelet derived growth factor-C (PDGF-C) has been shown to promote blood vessel growth and neuronal survival. Moreover, reductions of these neurotrophic and angiogenic factors in old age have been related to hippocampal atrophy, decreased vascularization and cognitive decline. In a 3-month aerobic exercise study, forty healthy older humans (60 to 77years) were pseudo-randomly assigned to either an aerobic exercise group (indoor treadmill, n=21) or to a control group (indoor progressive-muscle relaxation/stretching, n=19). As reported recently, we found evidence for fitness-related perfusion changes of the aged human hippocampus that were closely linked to changes in episodic memory function. Here, we test whether peripheral levels of BDNF, IGF-I, VEGF or PDGF-C are related to changes in hippocampal blood flow, volume and memory performance. Growth factor levels were not significantly affected by exercise, and their changes were not related to changes in fitness or perfusion. However, changes in IGF-I levels were positively correlated with hippocampal volume changes (derived by manual volumetry and voxel-based morphometry) and late verbal recall performance, a relationship that seemed to be independent of fitness, perfusion or their changes over time. These preliminary findings link IGF-I levels to hippocampal volume changes and putatively hippocampus-dependent memory changes that seem to occur over time independently of exercise. We discuss methodological shortcomings of our study and potential differences in the temporal dynamics of how IGF-1, VEGF and BDNF may be affected by exercise and to what extent these differences may have led to the negative findings reported here.
000138523 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000138523 542__ $$2Crossref$$i2016-05-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000138523 542__ $$2Crossref$$i2015-11-02$$uhttp://creativecommons.org/licenses/by-nc-nd/4.0/
000138523 588__ $$aDataset connected to CrossRef, PubMed,
000138523 650_7 $$2NLM Chemicals$$aBrain-Derived Neurotrophic Factor
000138523 650_7 $$2NLM Chemicals$$aVascular Endothelial Growth Factor A
000138523 650_7 $$067763-96-6$$2NLM Chemicals$$aInsulin-Like Growth Factor I
000138523 650_7 $$07171WSG8A2$$2NLM Chemicals$$aBDNF protein, human
000138523 650_2 $$2MeSH$$aAged
000138523 650_2 $$2MeSH$$aAging: physiology
000138523 650_2 $$2MeSH$$aBlood Flow Velocity: physiology
000138523 650_2 $$2MeSH$$aBrain-Derived Neurotrophic Factor: blood
000138523 650_2 $$2MeSH$$aCerebrovascular Circulation: physiology
000138523 650_2 $$2MeSH$$aExercise: physiology
000138523 650_2 $$2MeSH$$aFemale
000138523 650_2 $$2MeSH$$aHippocampus: physiology
000138523 650_2 $$2MeSH$$aHumans
000138523 650_2 $$2MeSH$$aInsulin-Like Growth Factor I: metabolism
000138523 650_2 $$2MeSH$$aMale
000138523 650_2 $$2MeSH$$aMemory: physiology
000138523 650_2 $$2MeSH$$aMiddle Aged
000138523 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000138523 650_2 $$2MeSH$$aOrgan Size: physiology
000138523 650_2 $$2MeSH$$aPhysical Conditioning, Human: methods
000138523 650_2 $$2MeSH$$aPhysical Fitness: physiology
000138523 650_2 $$2MeSH$$aVascular Endothelial Growth Factor A: blood
000138523 7001_ $$0P:(DE-HGF)0$$aDüzel, Sandra$$b1
000138523 7001_ $$0P:(DE-HGF)0$$aBrigadski, Tanja$$b2
000138523 7001_ $$0P:(DE-2719)2810311$$aGörke, Monique$$b3$$udzne
000138523 7001_ $$0P:(DE-2719)2811221$$aBecke, Andreas$$b4$$udzne
000138523 7001_ $$0P:(DE-2719)2761749$$aSobieray, Uwe$$b5$$udzne
000138523 7001_ $$0P:(DE-2719)2810407$$aNeumann, Katja$$b6$$udzne
000138523 7001_ $$0P:(DE-HGF)0$$aLövdén, Martin$$b7
000138523 7001_ $$0P:(DE-HGF)0$$aLindenberger, Ulman$$b8
000138523 7001_ $$0P:(DE-HGF)0$$aBäckman, Lars$$b9
000138523 7001_ $$0P:(DE-HGF)0$$aBraun-Dullaeus, Rüdiger$$b10
000138523 7001_ $$0P:(DE-HGF)0$$aAhrens, Dörte$$b11
000138523 7001_ $$0P:(DE-2719)2260426$$aHeinze, Hans-Jochen$$b12$$udzne
000138523 7001_ $$0P:(DE-2719)2191623$$aMüller, Notger G$$b13$$udzne
000138523 7001_ $$0P:(DE-HGF)0$$aLessmann, Volkmar$$b14
000138523 7001_ $$0P:(DE-HGF)0$$aSendtner, Michael$$b15
000138523 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b16$$eLast author$$udzne
000138523 77318 $$2Crossref$$3journal-article$$a10.1016/j.neuroimage.2015.10.084$$b : Elsevier BV, 2016-05-01$$p142-154$$tNeuroImage$$v131$$x1053-8119$$y2016
000138523 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2015.10.084$$gVol. 131, p. 142 - 154$$p142-154$$q131<142 - 154$$tNeuroImage$$v131$$x1053-8119$$y2016
000138523 8564_ $$uhttps://pub.dzne.de/record/138523/files/DZNE-2020-04845.pdf$$yOpenAccess
000138523 8564_ $$uhttps://pub.dzne.de/record/138523/files/DZNE-2020-04845.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000138523 909CO $$ooai:pub.dzne.de:138523$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811815$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810311$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811221$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2761749$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810407$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2260426$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2191623$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000138523 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000005$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b16$$kDZNE
000138523 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000138523 9141_ $$y2016
000138523 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000138523 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000138523 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000138523 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000138523 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROIMAGE : 2017
000138523 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000138523 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000138523 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000138523 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000138523 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000138523 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNEUROIMAGE : 2017
000138523 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000138523 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000138523 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000138523 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000138523 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000138523 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x0
000138523 9201_ $$0I:(DE-2719)1310003$$kAG Müller$$lNeuroprotection$$x1
000138523 9201_ $$0I:(DE-2719)1340007$$kCore Technical Staff$$lCore KAP (Kooperationseinheit Angewandte Präventionsforschung)$$x2
000138523 9201_ $$0I:(DE-2719)1340009$$kAG Speck$$lLinking imaging projects iNET$$x3
000138523 9201_ $$0I:(DE-2719)7000000$$kU Clinical Researchers - Magdeburg$$lU Clinical Researchers - Magdeburg$$x4
000138523 980__ $$ajournal
000138523 980__ $$aVDB
000138523 980__ $$aI:(DE-2719)5000006
000138523 980__ $$aI:(DE-2719)1310003
000138523 980__ $$aI:(DE-2719)1340007
000138523 980__ $$aI:(DE-2719)1340009
000138523 980__ $$aI:(DE-2719)7000000
000138523 980__ $$aUNRESTRICTED
000138523 9801_ $$aFullTexts