TY  - JOUR
AU  - Maaß, Anne
AU  - Düzel, Sandra
AU  - Brigadski, Tanja
AU  - Görke, Monique
AU  - Becke, Andreas
AU  - Sobieray, Uwe
AU  - Neumann, Katja
AU  - Lövdén, Martin
AU  - Lindenberger, Ulman
AU  - Bäckman, Lars
AU  - Braun-Dullaeus, Rüdiger
AU  - Ahrens, Dörte
AU  - Heinze, Hans-Jochen
AU  - Müller, Notger G
AU  - Lessmann, Volkmar
AU  - Sendtner, Michael
AU  - Düzel, Emrah
TI  - Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults.
JO  - NeuroImage
VL  - 131
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2020-04845
SP  - 142-154
PY  - 2016
AB  - Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating exercise-induced structural and functional changes in the hippocampus. Recently, also platelet derived growth factor-C (PDGF-C) has been shown to promote blood vessel growth and neuronal survival. Moreover, reductions of these neurotrophic and angiogenic factors in old age have been related to hippocampal atrophy, decreased vascularization and cognitive decline. In a 3-month aerobic exercise study, forty healthy older humans (60 to 77years) were pseudo-randomly assigned to either an aerobic exercise group (indoor treadmill, n=21) or to a control group (indoor progressive-muscle relaxation/stretching, n=19). As reported recently, we found evidence for fitness-related perfusion changes of the aged human hippocampus that were closely linked to changes in episodic memory function. Here, we test whether peripheral levels of BDNF, IGF-I, VEGF or PDGF-C are related to changes in hippocampal blood flow, volume and memory performance. Growth factor levels were not significantly affected by exercise, and their changes were not related to changes in fitness or perfusion. However, changes in IGF-I levels were positively correlated with hippocampal volume changes (derived by manual volumetry and voxel-based morphometry) and late verbal recall performance, a relationship that seemed to be independent of fitness, perfusion or their changes over time. These preliminary findings link IGF-I levels to hippocampal volume changes and putatively hippocampus-dependent memory changes that seem to occur over time independently of exercise. We discuss methodological shortcomings of our study and potential differences in the temporal dynamics of how IGF-1, VEGF and BDNF may be affected by exercise and to what extent these differences may have led to the negative findings reported here.
KW  - Aged
KW  - Aging: physiology
KW  - Blood Flow Velocity: physiology
KW  - Brain-Derived Neurotrophic Factor: blood
KW  - Cerebrovascular Circulation: physiology
KW  - Exercise: physiology
KW  - Female
KW  - Hippocampus: physiology
KW  - Humans
KW  - Insulin-Like Growth Factor I: metabolism
KW  - Male
KW  - Memory: physiology
KW  - Middle Aged
KW  - Neuronal Plasticity: physiology
KW  - Organ Size: physiology
KW  - Physical Conditioning, Human: methods
KW  - Physical Fitness: physiology
KW  - Vascular Endothelial Growth Factor A: blood
KW  - Brain-Derived Neurotrophic Factor (NLM Chemicals)
KW  - Vascular Endothelial Growth Factor A (NLM Chemicals)
KW  - Insulin-Like Growth Factor I (NLM Chemicals)
KW  - BDNF protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26545456
DO  - DOI:10.1016/j.neuroimage.2015.10.084
UR  - https://pub.dzne.de/record/138523
ER  -