TY  - JOUR
AU  - Hong, Ja Bin
AU  - Leonards, Christopher O
AU  - Endres, Matthias
AU  - Siegerink, Bob
AU  - Liman, Thomas G
TI  - Ankle-Brachial Index and Recurrent Stroke Risk: Meta-Analysis.
JO  - Stroke
VL  - 47
IS  - 2
SN  - 0039-2499
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - DZNE-2020-04916
SP  - 317-322
PY  - 2016
AB  - The ankle-brachial index (ABI) is a fast, cheap, noninvasive indicator of atherosclerotic burden that may also be a predictor of stroke recurrence. In this systematic review and meta-analysis, we sought to explore ABI's merit as a marker for stroke recurrence and vascular risk by synthesizing the data currently available in stroke literature.We searched Embase, MEDLINE, and Pubmed databases for prospective cohort studies that included consecutive patients with stroke and transient ischemic attack, measured ABI at baseline, and performed a follow-up assessment at least 12 months after initial stroke or transient ischemic attack. The following end points were chosen for our analysis: recurrent stroke and combined vascular end point (recurrent vascular event or vascular death). Crude risk ratios and adjusted Cox proportional hazard ratios were combined separately using the random-effects model. Study-level characteristics (eg, percent of cohort with a history of hypertension, average cohort age, level of adjustment, and mean follow-up duration) were included as covariates in a metaregression analysis.We identified 11 studies (5374 patients) that were not significantly heterogeneous. Pooling adjusted hazard ratios showed that low ABI was associated with both an increased hazard of recurrent stroke (hazard ratio, 1.70; 95
KW  - Age Factors
KW  - Ankle Brachial Index: statistics & numerical data
KW  - Atherosclerosis: epidemiology
KW  - Atherosclerosis: physiopathology
KW  - Humans
KW  - Hypertension: epidemiology
KW  - Ischemic Attack, Transient: epidemiology
KW  - Multivariate Analysis
KW  - Odds Ratio
KW  - Proportional Hazards Models
KW  - Recurrence
KW  - Risk Assessment
KW  - Severity of Illness Index
KW  - Stroke: epidemiology
LB  - PUB:(DE-HGF)16
C6  - pmid:26658450
DO  - DOI:10.1161/STROKEAHA.115.011321
UR  - https://pub.dzne.de/record/138594
ER  -