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@ARTICLE{Melzer:138658,
      author       = {Melzer, Juliane and Brömer, Meike},
      title        = {{N}erve-racking - apoptotic and non-apoptotic roles of
                      caspases in the nervous system of {D}rosophila.},
      journal      = {European journal of neuroscience},
      volume       = {44},
      number       = {1},
      issn         = {0953-816X},
      address      = {Oxford [u.a.]},
      publisher    = {Blackwell},
      reportid     = {DZNE-2020-04980},
      pages        = {1683-1690},
      year         = {2016},
      abstract     = {Studies using Drosophila as a model system have contributed
                      enormously to our knowledge of caspase function and
                      regulation. Caspases are best known as central executioners
                      of apoptosis but also control essential physiological
                      processes in a non-apoptotic manner. The Drosophila genome
                      codes for seven caspases and in this review we provide an
                      overview of current knowledge about caspase function in the
                      nervous system. Caspases regulate neuronal death at all
                      developmental stages and in various neuronal populations. In
                      contrast, non-apoptotic roles are less well understood. The
                      development of new genetically encoded sensors for caspase
                      activity provides unprecedented opportunities to study
                      caspase function in the nervous system in more detail. In
                      light of these new tools we discuss the potential of
                      Drosophila as a model to discover new apoptotic and
                      non-apoptotic neuronal roles of caspases.},
      subtyp        = {Review Article},
      keywords     = {Animals / Apoptosis / Caspases: genetics / Caspases:
                      metabolism / Drosophila: genetics / Drosophila: growth $\&$
                      development / Drosophila: metabolism / Drosophila Proteins:
                      genetics / Drosophila Proteins: metabolism / Nervous System:
                      metabolism / Neurogenesis / Drosophila Proteins (NLM
                      Chemicals) / Caspases (NLM Chemicals)},
      cin          = {AG Brömer 1},
      ddc          = {610},
      cid          = {I:(DE-2719)5000021},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26900934},
      doi          = {10.1111/ejn.13213},
      url          = {https://pub.dzne.de/record/138658},
}