Home > Publications Database > Nerve-racking - apoptotic and non-apoptotic roles of caspases in the nervous system of Drosophila. > print

001     138658
005     20240321220458.0
024 7 _ |a 10.1111/ejn.13213
|2 doi
024 7 _ |a pmid:26900934
|2 pmid
024 7 _ |a 0953-816X
|2 ISSN
024 7 _ |a 1460-9568
|2 ISSN
024 7 _ |a altmetric:5955284
|2 altmetric
037 _ _ |a DZNE-2020-04980
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Melzer, Juliane
|0 P:(DE-2719)2810805
|b 0
|e First author
245 _ _ |a Nerve-racking - apoptotic and non-apoptotic roles of caspases in the nervous system of Drosophila.
260 _ _ |a Oxford [u.a.]
|c 2016
|b Blackwell
264 _ 1 |3 online
|2 Crossref
|b Wiley
|c 2016-03-19
264 _ 1 |3 print
|2 Crossref
|b Wiley
|c 2016-07-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
|b journal
|m journal
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|s 1590677733_3940
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|x Review Article
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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|2 EndNote
520 _ _ |a Studies using Drosophila as a model system have contributed enormously to our knowledge of caspase function and regulation. Caspases are best known as central executioners of apoptosis but also control essential physiological processes in a non-apoptotic manner. The Drosophila genome codes for seven caspases and in this review we provide an overview of current knowledge about caspase function in the nervous system. Caspases regulate neuronal death at all developmental stages and in various neuronal populations. In contrast, non-apoptotic roles are less well understood. The development of new genetically encoded sensors for caspase activity provides unprecedented opportunities to study caspase function in the nervous system in more detail. In light of these new tools we discuss the potential of Drosophila as a model to discover new apoptotic and non-apoptotic neuronal roles of caspases.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
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542 _ _ |i 2015-09-01
|2 Crossref
|u http://doi.wiley.com/10.1002/tdm_license_1.1
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Drosophila Proteins
|2 NLM Chemicals
650 _ 7 |a Caspases
|0 EC 3.4.22.-
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Apoptosis
|2 MeSH
650 _ 2 |a Caspases: genetics
|2 MeSH
650 _ 2 |a Caspases: metabolism
|2 MeSH
650 _ 2 |a Drosophila: genetics
|2 MeSH
650 _ 2 |a Drosophila: growth & development
|2 MeSH
650 _ 2 |a Drosophila: metabolism
|2 MeSH
650 _ 2 |a Drosophila Proteins: genetics
|2 MeSH
650 _ 2 |a Drosophila Proteins: metabolism
|2 MeSH
650 _ 2 |a Nervous System: metabolism
|2 MeSH
650 _ 2 |a Neurogenesis
|2 MeSH
700 1 _ |a Brömer, Meike
|0 P:(DE-2719)2810307
|b 1
|e Last author
773 1 8 |a 10.1111/ejn.13213
|b : Wiley, 2016-03-19
|n 1
|p 1683-1690
|3 journal-article
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|t European Journal of Neuroscience
|v 44
|y 2016
|x 0953-816X
773 _ _ |a 10.1111/ejn.13213
|g Vol. 44, no. 1, p. 1683 - 1690
|0 PERI:(DE-600)2005178-5
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|p 1683-1690
|t European journal of neuroscience
|v 44
|y 2016
|x 0953-816X
909 C O |p VDB
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
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914 1 _ |y 2016
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Marc 21