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000138664 1001_ $$0P:(DE-HGF)0$$aMachado, Venissa$$b0
000138664 245__ $$aGdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice.
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000138664 520__ $$aGrowth/differentiation factor-15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has also been shown to be involved in inflammatory processes. The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice. At 4 days and 14 days post-MPTP administration, both Gdf-15 (+/+) and Gdf-15 (-/-) mice showed a similar decline in DAergic neuron numbers and in striatal dopamine (DA) levels. This was followed by a comparable restorative phase at 90 days and 120 days, indicating that the absence of Gdf-15 does not affect the susceptibility or the recovery capacity of the nigrostriatal system after MPTP administration. The MPTP-induced microglial and astrocytic response was not significantly altered between the two genotypes. However, pro-inflammatory and anti-inflammatory cytokine profiling revealed the differential expression of markers in Gdf-15 (+/+) and Gdf-15 (-/-) mice after MPTP administration. Thus, the MPTP mouse model fails to uncover a major role of endogenous Gdf-15 in the protection of MPTP-lesioned nigrostriatal DAergic neurons, in contrast to its capacity to protect the 6-hydroxydopamine-intoxicated nigrostriatal system.
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000138664 650_7 $$2NLM Chemicals$$aBiomarkers
000138664 650_7 $$2NLM Chemicals$$aCytokines
000138664 650_7 $$2NLM Chemicals$$aGdf15 protein, mouse
000138664 650_7 $$2NLM Chemicals$$aGrowth Differentiation Factor 15
000138664 650_7 $$2NLM Chemicals$$aInflammation Mediators
000138664 650_7 $$2NLM Chemicals$$aRNA, Messenger
000138664 650_7 $$09P21XSP91P$$2NLM Chemicals$$a1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
000138664 650_2 $$2MeSH$$a1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: administration & dosage
000138664 650_2 $$2MeSH$$aAnimals
000138664 650_2 $$2MeSH$$aBiomarkers: metabolism
000138664 650_2 $$2MeSH$$aCell Proliferation
000138664 650_2 $$2MeSH$$aCytokines: metabolism
000138664 650_2 $$2MeSH$$aDopaminergic Neurons: metabolism
000138664 650_2 $$2MeSH$$aGrowth Differentiation Factor 15: deficiency
000138664 650_2 $$2MeSH$$aGrowth Differentiation Factor 15: metabolism
000138664 650_2 $$2MeSH$$aInflammation Mediators: metabolism
000138664 650_2 $$2MeSH$$aMice
000138664 650_2 $$2MeSH$$aNeostriatum: metabolism
000138664 650_2 $$2MeSH$$aNeostriatum: pathology
000138664 650_2 $$2MeSH$$aNeuroglia: metabolism
000138664 650_2 $$2MeSH$$aRNA, Messenger: genetics
000138664 650_2 $$2MeSH$$aRNA, Messenger: metabolism
000138664 650_2 $$2MeSH$$aSubstantia Nigra: metabolism
000138664 650_2 $$2MeSH$$aSubstantia Nigra: pathology
000138664 7001_ $$0P:(DE-HGF)0$$aGilsbach, Ralf$$b1
000138664 7001_ $$0P:(DE-2719)2811341$$aDas, Richa$$b2$$udzne
000138664 7001_ $$0P:(DE-HGF)0$$aSchober, Andreas$$b3
000138664 7001_ $$0P:(DE-HGF)0$$aBogatyreva, Lioudmila$$b4
000138664 7001_ $$0P:(DE-2719)9000119$$aHauschke, Dieter$$b5$$udzne
000138664 7001_ $$0P:(DE-HGF)0$$aKrieglstein, Kerstin$$b6
000138664 7001_ $$0P:(DE-HGF)0$$aUnsicker, Klaus$$b7$$eCorresponding author
000138664 7001_ $$0P:(DE-HGF)0$$aSpittau, Björn$$b8
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