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| Home > Publications Database > Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. > print |
| 001 | 138664 | ||
| 005 | 20240410133151.0 | ||
| 024 | 7 | _ | |a 2192-5917 |2 ISSN |
| 024 | 7 | _ | |a 10.1007/s00441-016-2406-x |2 doi |
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| 037 | _ | _ | |a DZNE-2020-04986 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Machado, Venissa |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. |
| 260 | _ | _ | |a Heidelberg |c 2016 |b Springer |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2016-04-26 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2016-08-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1712748656_11350 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Growth/differentiation factor-15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has also been shown to be involved in inflammatory processes. The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice. At 4 days and 14 days post-MPTP administration, both Gdf-15 (+/+) and Gdf-15 (-/-) mice showed a similar decline in DAergic neuron numbers and in striatal dopamine (DA) levels. This was followed by a comparable restorative phase at 90 days and 120 days, indicating that the absence of Gdf-15 does not affect the susceptibility or the recovery capacity of the nigrostriatal system after MPTP administration. The MPTP-induced microglial and astrocytic response was not significantly altered between the two genotypes. However, pro-inflammatory and anti-inflammatory cytokine profiling revealed the differential expression of markers in Gdf-15 (+/+) and Gdf-15 (-/-) mice after MPTP administration. Thus, the MPTP mouse model fails to uncover a major role of endogenous Gdf-15 in the protection of MPTP-lesioned nigrostriatal DAergic neurons, in contrast to its capacity to protect the 6-hydroxydopamine-intoxicated nigrostriatal system. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2016-04-26 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 7 | |a Cytokines |2 NLM Chemicals |
| 650 | _ | 7 | |a Gdf15 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Growth Differentiation Factor 15 |2 NLM Chemicals |
| 650 | _ | 7 | |a Inflammation Mediators |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA, Messenger |2 NLM Chemicals |
| 650 | _ | 7 | |a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |0 9P21XSP91P |2 NLM Chemicals |
| 650 | _ | 2 | |a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: administration & dosage |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Biomarkers: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Proliferation |2 MeSH |
| 650 | _ | 2 | |a Cytokines: metabolism |2 MeSH |
| 650 | _ | 2 | |a Dopaminergic Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Growth Differentiation Factor 15: deficiency |2 MeSH |
| 650 | _ | 2 | |a Growth Differentiation Factor 15: metabolism |2 MeSH |
| 650 | _ | 2 | |a Inflammation Mediators: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Neostriatum: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neostriatum: pathology |2 MeSH |
| 650 | _ | 2 | |a Neuroglia: metabolism |2 MeSH |
| 650 | _ | 2 | |a RNA, Messenger: genetics |2 MeSH |
| 650 | _ | 2 | |a RNA, Messenger: metabolism |2 MeSH |
| 650 | _ | 2 | |a Substantia Nigra: metabolism |2 MeSH |
| 650 | _ | 2 | |a Substantia Nigra: pathology |2 MeSH |
| 700 | 1 | _ | |a Gilsbach, Ralf |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Das, Richa |0 P:(DE-2719)2811341 |b 2 |u dzne |
| 700 | 1 | _ | |a Schober, Andreas |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Bogatyreva, Lioudmila |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Hauschke, Dieter |0 P:(DE-2719)9000119 |b 5 |u dzne |
| 700 | 1 | _ | |a Krieglstein, Kerstin |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Unsicker, Klaus |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 700 | 1 | _ | |a Spittau, Björn |0 P:(DE-HGF)0 |b 8 |
| 773 | 1 | 8 | |a 10.1007/s00441-016-2406-x |b : Springer Science and Business Media LLC, 2016-04-26 |n 2 |p 209-223 |3 journal-article |2 Crossref |t Cell and Tissue Research |v 365 |y 2016 |x 0302-766X |
| 773 | _ | _ | |a 10.1007/s00441-016-2406-x |g Vol. 365, no. 2, p. 209 - 223 |0 PERI:(DE-600)1458496-7 |n 2 |q 365:2<209 - 223 |p 209-223 |t Cell & tissue research |v 365 |y 2016 |x 0302-766X |
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