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000138696 0247_ $$2doi$$a10.1016/j.jalz.2016.01.006
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000138696 0247_ $$2ISSN$$a1552-5260
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000138696 1001_ $$0P:(DE-HGF)0$$aLouwersheimer, Eva$$b0$$eCorresponding author
000138696 245__ $$aAlzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment.
000138696 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2016
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000138696 520__ $$aWe evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).PGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:-0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10(-4); ptau: 1.40 ± 0.36, P = 1.02 × 10(-4)).In MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition.
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000138696 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000138696 650_7 $$2NLM Chemicals$$aApolipoproteins E
000138696 650_2 $$2MeSH$$aAged
000138696 650_2 $$2MeSH$$aAged, 80 and over
000138696 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000138696 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000138696 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid
000138696 650_2 $$2MeSH$$aApolipoproteins E: genetics
000138696 650_2 $$2MeSH$$aCognitive Dysfunction: cerebrospinal fluid
000138696 650_2 $$2MeSH$$aCognitive Dysfunction: complications
000138696 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000138696 650_2 $$2MeSH$$aCohort Studies
000138696 650_2 $$2MeSH$$aDatasets as Topic: statistics & numerical data
000138696 650_2 $$2MeSH$$aEndophenotypes: cerebrospinal fluid
000138696 650_2 $$2MeSH$$aFemale
000138696 650_2 $$2MeSH$$aHumans
000138696 650_2 $$2MeSH$$aMale
000138696 650_2 $$2MeSH$$aMental Status Schedule
000138696 650_2 $$2MeSH$$aMiddle Aged
000138696 650_2 $$2MeSH$$aMultifactorial Inheritance: genetics
000138696 650_2 $$2MeSH$$aNeuropsychological Tests
000138696 650_2 $$2MeSH$$aOdds Ratio
000138696 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000138696 650_2 $$2MeSH$$aStatistics, Nonparametric
000138696 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b1$$udzne
000138696 7001_ $$aEspinosa, Ana$$b2
000138696 7001_ $$0P:(DE-2719)2810305$$aLacour, André$$b3$$udzne
000138696 7001_ $$aHeilmann-Heimbach, Stefanie$$b4
000138696 7001_ $$aAlegret, Montserrat$$b5
000138696 7001_ $$aHernández, Isabel$$b6
000138696 7001_ $$aRosende-Roca, Maitée$$b7
000138696 7001_ $$aTárraga, Lluís$$b8
000138696 7001_ $$aBoada, Mercè$$b9
000138696 7001_ $$aKornhuber, Johannes$$b10
000138696 7001_ $$0P:(DE-HGF)0$$aPeters, Oliver$$b11
000138696 7001_ $$aFrölich, Lutz$$b12
000138696 7001_ $$aHüll, Michael$$b13
000138696 7001_ $$0P:(DE-HGF)0$$aRüther, Eckart$$b14
000138696 7001_ $$0P:(DE-HGF)0$$aWiltfang, Jens$$b15
000138696 7001_ $$aScherer, Martin$$b16
000138696 7001_ $$aRiedel-Heller, Steffi$$b17
000138696 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b18
000138696 7001_ $$0P:(DE-HGF)0$$aNöthen, Markus M$$b19
000138696 7001_ $$0P:(DE-2719)2000015$$aMaier, Wolfgang$$b20$$udzne
000138696 7001_ $$aKoene, Ted$$b21
000138696 7001_ $$aScheltens, Philip$$b22
000138696 7001_ $$aHolstege, Henne$$b23
000138696 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b24$$udzne
000138696 7001_ $$aRuiz, Agustín$$b25
000138696 7001_ $$avan der Flier, Wiesje M$$b26
000138696 7001_ $$0P:(DE-HGF)0$$aBecker, Tim$$b27
000138696 7001_ $$0P:(DE-HGF)0$$aRamirez, Alfredo$$b28
000138696 77318 $$2Crossref$$3journal-article$$a10.1016/j.jalz.2016.01.006$$b : Wiley, 2016-02-24$$n8$$p872-881$$tAlzheimer's & Dementia$$v12$$x1552-5260$$y2016
000138696 773__ $$0PERI:(DE-600)2201940-6$$a10.1016/j.jalz.2016.01.006$$gVol. 12, no. 8, p. 872 - 881$$n8$$p872-881$$q12:8<872 - 881$$tAlzheimer's and dementia$$v12$$x1552-5260$$y2016
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