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| 001 | 138696 | ||
| 005 | 20240321220502.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jalz.2016.01.006 |2 doi |
| 024 | 7 | _ | |a pmid:26921674 |2 pmid |
| 024 | 7 | _ | |a 1552-5260 |2 ISSN |
| 024 | 7 | _ | |a 1552-5279 |2 ISSN |
| 024 | 7 | _ | |a altmetric:5994559 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05018 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Louwersheimer, Eva |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2016 |b Elsevier |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2016-02-24 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2016-08-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1684845107_10422 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).PGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:-0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10(-4); ptau: 1.40 ± 0.36, P = 1.02 × 10(-4)).In MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 536 | _ | _ | |a 345 - Population Studies and Genetics (POF3-345) |0 G:(DE-HGF)POF3-345 |c POF3-345 |f POF III |x 1 |
| 542 | _ | _ | |i 2016-02-24 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 542 | _ | _ | |i 2016-02-24 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 542 | _ | _ | |i 2017-08-05 |2 Crossref |u http://www.elsevier.com/open-access/userlicense/1.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Apolipoproteins E |2 NLM Chemicals |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Apolipoproteins E: genetics |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: complications |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: genetics |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Datasets as Topic: statistics & numerical data |2 MeSH |
| 650 | _ | 2 | |a Endophenotypes: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mental Status Schedule |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Multifactorial Inheritance: genetics |2 MeSH |
| 650 | _ | 2 | |a Neuropsychological Tests |2 MeSH |
| 650 | _ | 2 | |a Odds Ratio |2 MeSH |
| 650 | _ | 2 | |a Polymorphism, Single Nucleotide: genetics |2 MeSH |
| 650 | _ | 2 | |a Statistics, Nonparametric |2 MeSH |
| 700 | 1 | _ | |a Wolfsgruber, Steffen |0 P:(DE-2719)2810544 |b 1 |u dzne |
| 700 | 1 | _ | |a Espinosa, Ana |b 2 |
| 700 | 1 | _ | |a Lacour, André |0 P:(DE-2719)2810305 |b 3 |u dzne |
| 700 | 1 | _ | |a Heilmann-Heimbach, Stefanie |b 4 |
| 700 | 1 | _ | |a Alegret, Montserrat |b 5 |
| 700 | 1 | _ | |a Hernández, Isabel |b 6 |
| 700 | 1 | _ | |a Rosende-Roca, Maitée |b 7 |
| 700 | 1 | _ | |a Tárraga, Lluís |b 8 |
| 700 | 1 | _ | |a Boada, Mercè |b 9 |
| 700 | 1 | _ | |a Kornhuber, Johannes |b 10 |
| 700 | 1 | _ | |a Peters, Oliver |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Frölich, Lutz |b 12 |
| 700 | 1 | _ | |a Hüll, Michael |b 13 |
| 700 | 1 | _ | |a Rüther, Eckart |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Wiltfang, Jens |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Scherer, Martin |b 16 |
| 700 | 1 | _ | |a Riedel-Heller, Steffi |b 17 |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Nöthen, Markus M |0 P:(DE-HGF)0 |b 19 |
| 700 | 1 | _ | |a Maier, Wolfgang |0 P:(DE-2719)2000015 |b 20 |u dzne |
| 700 | 1 | _ | |a Koene, Ted |b 21 |
| 700 | 1 | _ | |a Scheltens, Philip |b 22 |
| 700 | 1 | _ | |a Holstege, Henne |b 23 |
| 700 | 1 | _ | |a Wagner, Michael |0 P:(DE-2719)2000057 |b 24 |u dzne |
| 700 | 1 | _ | |a Ruiz, Agustín |b 25 |
| 700 | 1 | _ | |a van der Flier, Wiesje M |b 26 |
| 700 | 1 | _ | |a Becker, Tim |0 P:(DE-HGF)0 |b 27 |
| 700 | 1 | _ | |a Ramirez, Alfredo |0 P:(DE-HGF)0 |b 28 |
| 773 | 1 | 8 | |a 10.1016/j.jalz.2016.01.006 |b : Wiley, 2016-02-24 |n 8 |p 872-881 |3 journal-article |2 Crossref |t Alzheimer's & Dementia |v 12 |y 2016 |x 1552-5260 |
| 773 | _ | _ | |a 10.1016/j.jalz.2016.01.006 |g Vol. 12, no. 8, p. 872 - 881 |0 PERI:(DE-600)2201940-6 |n 8 |q 12:8<872 - 881 |p 872-881 |t Alzheimer's and dementia |v 12 |y 2016 |x 1552-5260 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/138696/files/DZNE-2020-05018.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/138696/files/DZNE-2020-05018.pdf?subformat=pdfa |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2810544 |
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| 914 | 1 | _ | |y 2016 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 |0 LIC:(DE-HGF)CCBYNCND4 |2 HGFVOC |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ALZHEIMERS DEMENT : 2017 |
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| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
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| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
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| 920 | 1 | _ | |0 I:(DE-2719)1011201 |k AG Wagner |l Neuropsychology |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013007 |k AG Becker ; GenomMathematik ; GenomMathematik |l GenomMathematik in der Neuroepidemiologie |x 1 |
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| 980 | _ | _ | |a UNRESTRICTED |
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| 999 | C | 5 | |y 1996 |2 Crossref |t SIDAM-A structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct (or vascular) dementia and dementias of other aetiology according to DSM-III-R, DSM-IV, and ICD-10 (SIDAM-manual) |o Zaudig SIDAM-A structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct (or vascular) dementia and dementias of other aetiology according to DSM-III-R, DSM-IV, and ICD-10 (SIDAM-manual) 1996 |
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