TY  - JOUR
AU  - Höhne, Marlene
AU  - Jahanbekam, Amirhossein
AU  - Bauckhage, Christian
AU  - Axmacher, Nikolai
AU  - Fell, Juergen
TI  - Prediction of successful memory encoding based on single-trial rhinal and hippocampal phase information.
JO  - NeuroImage
VL  - 139
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2020-05032
SP  - 127-135
PY  - 2016
AB  - Mediotemporal EEG characteristics are closely related to long-term memory formation. It has been reported that rhinal and hippocampal EEG measures reflecting the stability of phases across trials are better suited to distinguish subsequently remembered from forgotten trials than event-related potentials or amplitude-based measures. Theoretical models suggest that the phase of EEG oscillations reflects neural excitability and influences cellular plasticity. However, while previous studies have shown that the stability of phase values across trials is indeed a relevant predictor of subsequent memory performance, the effect of absolute single-trial phase values has been little explored. Here, we reanalyzed intracranial EEG recordings from the mediotemporal lobe of 27 epilepsy patients performing a continuous word recognition paradigm. Two-class classification using a support vector machine was performed to predict subsequently remembered vs. forgotten trials based on individually selected frequencies and time points. We demonstrate that it is possible to successfully predict single-trial memory formation in the majority of patients (23 out of 27) based on only three single-trial phase values given by a rhinal phase, a hippocampal phase, and a rhinal-hippocampal phase difference. Overall classification accuracy across all subjects was 69.2
KW  - Adolescent
KW  - Adult
KW  - Brain Mapping: methods
KW  - Computer Simulation
KW  - Cortical Synchronization: physiology
KW  - Electroencephalography: methods
KW  - Entorhinal Cortex: physiology
KW  - Female
KW  - Hippocampus: physiology
KW  - Humans
KW  - Male
KW  - Memory: physiology
KW  - Mental Recall: physiology
KW  - Middle Aged
KW  - Models, Neurological
KW  - Nerve Net: physiology
KW  - Reproducibility of Results
KW  - Sensitivity and Specificity
KW  - Task Performance and Analysis
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:27311642
DO  - DOI:10.1016/j.neuroimage.2016.06.021
UR  - https://pub.dzne.de/record/138710
ER  -