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@ARTICLE{Hhne:138710,
      author       = {Höhne, Marlene and Jahanbekam, Amirhossein and Bauckhage,
                      Christian and Axmacher, Nikolai and Fell, Juergen},
      title        = {{P}rediction of successful memory encoding based on
                      single-trial rhinal and hippocampal phase information.},
      journal      = {NeuroImage},
      volume       = {139},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2020-05032},
      pages        = {127-135},
      year         = {2016},
      abstract     = {Mediotemporal EEG characteristics are closely related to
                      long-term memory formation. It has been reported that rhinal
                      and hippocampal EEG measures reflecting the stability of
                      phases across trials are better suited to distinguish
                      subsequently remembered from forgotten trials than
                      event-related potentials or amplitude-based measures.
                      Theoretical models suggest that the phase of EEG
                      oscillations reflects neural excitability and influences
                      cellular plasticity. However, while previous studies have
                      shown that the stability of phase values across trials is
                      indeed a relevant predictor of subsequent memory
                      performance, the effect of absolute single-trial phase
                      values has been little explored. Here, we reanalyzed
                      intracranial EEG recordings from the mediotemporal lobe of
                      27 epilepsy patients performing a continuous word
                      recognition paradigm. Two-class classification using a
                      support vector machine was performed to predict subsequently
                      remembered vs. forgotten trials based on individually
                      selected frequencies and time points. We demonstrate that it
                      is possible to successfully predict single-trial memory
                      formation in the majority of patients (23 out of 27) based
                      on only three single-trial phase values given by a rhinal
                      phase, a hippocampal phase, and a rhinal-hippocampal phase
                      difference. Overall classification accuracy across all
                      subjects was $69.2\%$ choosing frequencies from the range
                      between 0.5 and 50Hz and time points from the interval
                      between -0.5s and 2s. For 19 patients, above chance
                      prediction of subsequent memory was possible even when
                      choosing only time points from the prestimulus interval
                      (overall accuracy: $65.2\%).$ Furthermore, prediction
                      accuracies based on single-trial phase surpassed those based
                      on single-trial power. Our results confirm the functional
                      relevance of mediotemporal EEG phase for long-term memory
                      operations and suggest that phase information may be
                      utilized for memory enhancement applications based on deep
                      brain stimulation.},
      keywords     = {Adolescent / Adult / Brain Mapping: methods / Computer
                      Simulation / Cortical Synchronization: physiology /
                      Electroencephalography: methods / Entorhinal Cortex:
                      physiology / Female / Hippocampus: physiology / Humans /
                      Male / Memory: physiology / Mental Recall: physiology /
                      Middle Aged / Models, Neurological / Nerve Net: physiology /
                      Reproducibility of Results / Sensitivity and Specificity /
                      Task Performance and Analysis / Young Adult},
      cin          = {AG Axmacher},
      ddc          = {610},
      cid          = {I:(DE-2719)5000027},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27311642},
      doi          = {10.1016/j.neuroimage.2016.06.021},
      url          = {https://pub.dzne.de/record/138710},
}