%0 Journal Article
%A Bacioglu, Mehtap
%A Maia, Luis F
%A Preische, Oliver
%A Schelle, Juliane
%A Apel, Anja
%A Kaeser, Stephan A
%A Schweighauser, Manuel
%A Eninger, Timo
%A Lambert, Marius
%A Pilotto, Andrea
%A Shimshek, Derya R
%A Neumann, Ulf
%A Kahle, Philipp J
%A Staufenbiel, Matthias
%A Neumann, Manuela
%A Maetzler, Walter
%A Kuhle, Jens
%A Jucker, Mathias
%T Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.
%J Neuron
%V 91
%N 1
%@ 0896-6273
%C New York, NY
%I Elsevier
%M DZNE-2020-05060
%P 56-66
%D 2016
%X A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein, Tau, Aβ). To monitor such treatments, fluid biomarkers reflecting the underlying disease process are crucial. We found robust increases of neurofilament light chain (NfL) in CSF and blood in murine models of α-synucleinopathies, tauopathy, and β-amyloidosis. Blood and CSF NfL levels were strongly correlated, and NfL increases coincided with the onset and progression of the corresponding proteopathic lesions in brain. Experimental induction of α-synuclein lesions increased CSF and blood NfL levels, while blocking Aβ lesions attenuated the NfL increase. Consistently, we also found NfL increases in CSF and blood of human α-synucleinopathies, tauopathies, and Alzheimer's disease. Our results suggest that CSF and particularly blood NfL can serve as a reliable and easily accessible biomarker to monitor disease progression and treatment response in mouse models and potentially in human proteopathic neurodegenerative diseases.
%K Animals
%K Axons: metabolism
%K Biomarkers: blood
%K Biomarkers: cerebrospinal fluid
%K Brain: metabolism
%K Brain: pathology
%K Disease Progression
%K Intermediate Filaments: metabolism
%K Mice, Inbred C57BL
%K Mice, Transgenic
%K Neurodegenerative Diseases: diagnosis
%K Neurodegenerative Diseases: metabolism
%K Neurodegenerative Diseases: pathology
%K Neurofilament Proteins: blood
%K Neurofilament Proteins: cerebrospinal fluid
%K alpha-Synuclein: metabolism
%K Biomarkers (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%K alpha-Synuclein (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27292537
%R 10.1016/j.neuron.2016.05.018
%U https://pub.dzne.de/record/138738