TY  - JOUR
AU  - Bacioglu, Mehtap
AU  - Maia, Luis F
AU  - Preische, Oliver
AU  - Schelle, Juliane
AU  - Apel, Anja
AU  - Kaeser, Stephan A
AU  - Schweighauser, Manuel
AU  - Eninger, Timo
AU  - Lambert, Marius
AU  - Pilotto, Andrea
AU  - Shimshek, Derya R
AU  - Neumann, Ulf
AU  - Kahle, Philipp J
AU  - Staufenbiel, Matthias
AU  - Neumann, Manuela
AU  - Maetzler, Walter
AU  - Kuhle, Jens
AU  - Jucker, Mathias
TI  - Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.
JO  - Neuron
VL  - 91
IS  - 1
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2020-05060
SP  - 56-66
PY  - 2016
AB  - A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein, Tau, Aβ). To monitor such treatments, fluid biomarkers reflecting the underlying disease process are crucial. We found robust increases of neurofilament light chain (NfL) in CSF and blood in murine models of α-synucleinopathies, tauopathy, and β-amyloidosis. Blood and CSF NfL levels were strongly correlated, and NfL increases coincided with the onset and progression of the corresponding proteopathic lesions in brain. Experimental induction of α-synuclein lesions increased CSF and blood NfL levels, while blocking Aβ lesions attenuated the NfL increase. Consistently, we also found NfL increases in CSF and blood of human α-synucleinopathies, tauopathies, and Alzheimer's disease. Our results suggest that CSF and particularly blood NfL can serve as a reliable and easily accessible biomarker to monitor disease progression and treatment response in mouse models and potentially in human proteopathic neurodegenerative diseases.
KW  - Animals
KW  - Axons: metabolism
KW  - Biomarkers: blood
KW  - Biomarkers: cerebrospinal fluid
KW  - Brain: metabolism
KW  - Brain: pathology
KW  - Disease Progression
KW  - Intermediate Filaments: metabolism
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - Neurodegenerative Diseases: diagnosis
KW  - Neurodegenerative Diseases: metabolism
KW  - Neurodegenerative Diseases: pathology
KW  - Neurofilament Proteins: blood
KW  - Neurofilament Proteins: cerebrospinal fluid
KW  - alpha-Synuclein: metabolism
KW  - Biomarkers (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - alpha-Synuclein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27292537
DO  - DOI:10.1016/j.neuron.2016.05.018
UR  - https://pub.dzne.de/record/138738
ER  -