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000138781 0247_ $$2doi$$a10.1093/brain/aww182
000138781 0247_ $$2pmid$$apmid:27412387
000138781 0247_ $$2ISSN$$a0006-8950
000138781 0247_ $$2ISSN$$a1460-2156
000138781 0247_ $$2altmetric$$aaltmetric:9671164
000138781 037__ $$aDZNE-2020-05103
000138781 041__ $$aEnglish
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000138781 1001_ $$0P:(DE-HGF)0$$aAccolla, Ettore A$$b0$$eCorresponding author
000138781 245__ $$aBrain networks modulated by subthalamic nucleus deep brain stimulation.
000138781 260__ $$aOxford$$bOxford Univ. Press$$c2016
000138781 264_1 $$2Crossref$$3online$$bOxford University Press (OUP)$$c2016-07-13
000138781 264_1 $$2Crossref$$3print$$bOxford University Press (OUP)$$c2016-09-01
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000138781 520__ $$aDeep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson's disease. Given the frequent occurrence of stimulation-induced affective and cognitive adverse effects, a better understanding about the role of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits modulated by subthalamic deep brain stimulation, and infer about the inner organization of the nucleus in terms of motor and non-motor areas. Given its small size and anatomical intersubject variability, functional organization of the subthalamic nucleus is difficult to investigate in vivo with current methods. Here, we used local field potential recordings obtained from 10 patients with Parkinson's disease to identify a subthalamic area with an analogous electrophysiological signature, namely a predominant beta oscillatory activity. The spatial accuracy was improved by identifying a single contact per macroelectrode for its vicinity to the electrophysiological source of the beta oscillation. We then conducted whole brain probabilistic tractography seeding from the previously identified contacts, and further described connectivity modifications along the macroelectrode's main axis. The designated subthalamic 'beta' area projected predominantly to motor and premotor cortical regions additional to connections to limbic and associative areas. More ventral subthalamic areas showed predominant connectivity to medial temporal regions including amygdala and hippocampus. We interpret our findings as evidence for the convergence of different functional circuits within subthalamic nucleus' portions deemed to be appropriate as deep brain stimulation target to treat motor symptoms in Parkinson's disease. Potential clinical implications of our study are illustrated by an index case where deep brain stimulation of estimated predominant non-motor subthalamic nucleus induced hypomanic behaviour.
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000138781 650_2 $$2MeSH$$aAged
000138781 650_2 $$2MeSH$$aAmygdala: diagnostic imaging
000138781 650_2 $$2MeSH$$aAmygdala: physiopathology
000138781 650_2 $$2MeSH$$aBeta Rhythm: physiology
000138781 650_2 $$2MeSH$$aCerebral Cortex: diagnostic imaging
000138781 650_2 $$2MeSH$$aCerebral Cortex: physiopathology
000138781 650_2 $$2MeSH$$aDeep Brain Stimulation
000138781 650_2 $$2MeSH$$aDiffusion Tensor Imaging: methods
000138781 650_2 $$2MeSH$$aElectroencephalography: methods
000138781 650_2 $$2MeSH$$aFemale
000138781 650_2 $$2MeSH$$aHumans
000138781 650_2 $$2MeSH$$aMale
000138781 650_2 $$2MeSH$$aMiddle Aged
000138781 650_2 $$2MeSH$$aNerve Net: diagnostic imaging
000138781 650_2 $$2MeSH$$aNerve Net: physiopathology
000138781 650_2 $$2MeSH$$aParkinson Disease: diagnostic imaging
000138781 650_2 $$2MeSH$$aParkinson Disease: physiopathology
000138781 650_2 $$2MeSH$$aParkinson Disease: therapy
000138781 650_2 $$2MeSH$$aSubthalamic Nucleus: diagnostic imaging
000138781 650_2 $$2MeSH$$aSubthalamic Nucleus: physiopathology
000138781 7001_ $$aHerrojo Ruiz, Maria$$b1
000138781 7001_ $$aHorn, Andreas$$b2
000138781 7001_ $$aSchneider, Gerd-Helge$$b3
000138781 7001_ $$0P:(DE-HGF)0$$aSchmitz-Hübsch, Tanja$$b4
000138781 7001_ $$aDraganski, Bogdan$$b5
000138781 7001_ $$0P:(DE-2719)2811089$$aKühn, Andrea A$$b6$$eLast author$$udzne
000138781 77318 $$2Crossref$$3journal-article$$a10.1093/brain/aww182$$b : Oxford University Press (OUP), 2016-07-13$$n9$$p2503-2515$$tBrain$$v139$$x0006-8950$$y2016
000138781 773__ $$0PERI:(DE-600)1474117-9$$a10.1093/brain/aww182$$gVol. 139, no. Pt 9, p. 2503 - 2515$$n9$$p2503-2515$$q139:Pt 9<2503 - 2515$$tBrain$$v139$$x0006-8950$$y2016
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