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@ARTICLE{Accolla:138781,
      author       = {Accolla, Ettore A and Herrojo Ruiz, Maria and Horn, Andreas
                      and Schneider, Gerd-Helge and Schmitz-Hübsch, Tanja and
                      Draganski, Bogdan and Kühn, Andrea A},
      title        = {{B}rain networks modulated by subthalamic nucleus deep
                      brain stimulation.},
      journal      = {Brain},
      volume       = {139},
      number       = {9},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2020-05103},
      pages        = {2503-2515},
      year         = {2016},
      abstract     = {Deep brain stimulation of the subthalamic nucleus is an
                      established treatment for the motor symptoms of Parkinson's
                      disease. Given the frequent occurrence of
                      stimulation-induced affective and cognitive adverse effects,
                      a better understanding about the role of the subthalamic
                      nucleus in non-motor functions is needed. The main goal of
                      this study is to characterize anatomical circuits modulated
                      by subthalamic deep brain stimulation, and infer about the
                      inner organization of the nucleus in terms of motor and
                      non-motor areas. Given its small size and anatomical
                      intersubject variability, functional organization of the
                      subthalamic nucleus is difficult to investigate in vivo with
                      current methods. Here, we used local field potential
                      recordings obtained from 10 patients with Parkinson's
                      disease to identify a subthalamic area with an analogous
                      electrophysiological signature, namely a predominant beta
                      oscillatory activity. The spatial accuracy was improved by
                      identifying a single contact per macroelectrode for its
                      vicinity to the electrophysiological source of the beta
                      oscillation. We then conducted whole brain probabilistic
                      tractography seeding from the previously identified
                      contacts, and further described connectivity modifications
                      along the macroelectrode's main axis. The designated
                      subthalamic 'beta' area projected predominantly to motor and
                      premotor cortical regions additional to connections to
                      limbic and associative areas. More ventral subthalamic areas
                      showed predominant connectivity to medial temporal regions
                      including amygdala and hippocampus. We interpret our
                      findings as evidence for the convergence of different
                      functional circuits within subthalamic nucleus' portions
                      deemed to be appropriate as deep brain stimulation target to
                      treat motor symptoms in Parkinson's disease. Potential
                      clinical implications of our study are illustrated by an
                      index case where deep brain stimulation of estimated
                      predominant non-motor subthalamic nucleus induced hypomanic
                      behaviour.},
      keywords     = {Aged / Amygdala: diagnostic imaging / Amygdala:
                      physiopathology / Beta Rhythm: physiology / Cerebral Cortex:
                      diagnostic imaging / Cerebral Cortex: physiopathology / Deep
                      Brain Stimulation / Diffusion Tensor Imaging: methods /
                      Electroencephalography: methods / Female / Humans / Male /
                      Middle Aged / Nerve Net: diagnostic imaging / Nerve Net:
                      physiopathology / Parkinson Disease: diagnostic imaging /
                      Parkinson Disease: physiopathology / Parkinson Disease:
                      therapy / Subthalamic Nucleus: diagnostic imaging /
                      Subthalamic Nucleus: physiopathology},
      cin          = {Clinical Study Team Berlin 2},
      ddc          = {610},
      cid          = {I:(DE-2719)5000008},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27412387},
      doi          = {10.1093/brain/aww182},
      url          = {https://pub.dzne.de/record/138781},
}