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| 001 | 138795 | ||
| 005 | 20240321220511.0 | ||
| 024 | 7 | _ | |a 10.1016/j.celrep.2016.08.093 |2 doi |
| 024 | 7 | _ | |a pmid:27681427 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5055474 |2 pmc |
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| 037 | _ | _ | |a DZNE-2020-05117 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Manière, Gérard |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. |
| 260 | _ | _ | |a [New York, NY] |c 2016 |b Elsevier |
| 264 | _ | 1 | |3 print |2 Crossref |b Elsevier BV |c 2016-09-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1710341167_30566 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs) sense leucine and regulate insulin secretion is still poorly understood. In Drosophila, insulin-like peptides (DILP2 and DILP5) are produced by brain IPCs and are released in the hemolymph after leucine ingestion. Using Ca(2+)-imaging and ex vivo cultured larval brains, we demonstrate that IPCs can directly sense extracellular leucine levels via minidiscs (MND), a leucine transporter. MND knockdown in IPCs abolished leucine-dependent changes, including loss of DILP2 and DILP5 in IPC bodies, consistent with the idea that MND is necessary for leucine-dependent DILP release. This, in turn, leads to a strong increase in hemolymph sugar levels and reduced growth. GDH knockdown in IPCs also reduced leucine-dependent DILP release, suggesting that nutrient sensing is coupled to the glutamate dehydrogenase pathway. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2016-09-01 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 542 | _ | _ | |i 2016-08-31 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amino Acid Transport Systems |2 NLM Chemicals |
| 650 | _ | 7 | |a Drosophila Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Ilp5 protein, Drosophila |2 NLM Chemicals |
| 650 | _ | 7 | |a Insulins |2 NLM Chemicals |
| 650 | _ | 7 | |a Mnd protein, Drosophila |2 NLM Chemicals |
| 650 | _ | 7 | |a Protein Isoforms |2 NLM Chemicals |
| 650 | _ | 7 | |a Glutamate Dehydrogenase |0 EC 1.4.1.2 |2 NLM Chemicals |
| 650 | _ | 7 | |a Leucine |0 GMW67QNF9C |2 NLM Chemicals |
| 650 | _ | 7 | |a Calcium |0 SY7Q814VUP |2 NLM Chemicals |
| 650 | _ | 2 | |a Amino Acid Transport Systems: genetics |2 MeSH |
| 650 | _ | 2 | |a Amino Acid Transport Systems: metabolism |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Brain: cytology |2 MeSH |
| 650 | _ | 2 | |a Brain: metabolism |2 MeSH |
| 650 | _ | 2 | |a Calcium: metabolism |2 MeSH |
| 650 | _ | 2 | |a Drosophila Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Drosophila Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: cytology |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: metabolism |2 MeSH |
| 650 | _ | 2 | |a Gene Expression Regulation |2 MeSH |
| 650 | _ | 2 | |a Glutamate Dehydrogenase: genetics |2 MeSH |
| 650 | _ | 2 | |a Glutamate Dehydrogenase: metabolism |2 MeSH |
| 650 | _ | 2 | |a Hemolymph: metabolism |2 MeSH |
| 650 | _ | 2 | |a Insulin-Secreting Cells: cytology |2 MeSH |
| 650 | _ | 2 | |a Insulin-Secreting Cells: metabolism |2 MeSH |
| 650 | _ | 2 | |a Insulins: genetics |2 MeSH |
| 650 | _ | 2 | |a Insulins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Larva: cytology |2 MeSH |
| 650 | _ | 2 | |a Larva: metabolism |2 MeSH |
| 650 | _ | 2 | |a Leucine: administration & dosage |2 MeSH |
| 650 | _ | 2 | |a Leucine: metabolism |2 MeSH |
| 650 | _ | 2 | |a Protein Isoforms: genetics |2 MeSH |
| 650 | _ | 2 | |a Protein Isoforms: metabolism |2 MeSH |
| 650 | _ | 2 | |a Signal Transduction |2 MeSH |
| 700 | 1 | _ | |a Ziegler, Anna B |0 P:(DE-2719)2811714 |b 1 |u dzne |
| 700 | 1 | _ | |a Geillon, Flore |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Featherstone, David E |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Grosjean, Yael |0 P:(DE-HGF)0 |b 4 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1016/j.celrep.2016.08.093 |b : Elsevier BV, 2016-09-01 |n 1 |p 137-148 |3 journal-article |2 Crossref |t Cell Reports |v 17 |y 2016 |x 2211-1247 |
| 773 | _ | _ | |a 10.1016/j.celrep.2016.08.093 |g Vol. 17, no. 1, p. 137 - 148 |0 PERI:(DE-600)2649101-1 |n 1 |q 17:1<137 - 148 |p 137-148 |t Cell reports |v 17 |y 2016 |x 2211-1247 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/138795/files/DZNE-2020-05117.pdf |
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| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055474 |
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