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000138797 0247_ $$2doi$$a10.3233/JAD-151006
000138797 0247_ $$2pmid$$apmid:27567804
000138797 0247_ $$2ISSN$$a1387-2877
000138797 0247_ $$2ISSN$$a1875-8908
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000138797 037__ $$aDZNE-2020-05119
000138797 041__ $$aEnglish
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000138797 1001_ $$0P:(DE-2719)2811376$$aGomm, Willy$$b0$$eFirst author$$udzne
000138797 245__ $$aRegular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data.
000138797 260__ $$aAmsterdam$$bIOS Press$$c2016
000138797 264_1 $$2Crossref$$3print$$bIOS Press$$c2016-09-06
000138797 3367_ $$2DRIVER$$aarticle
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000138797 520__ $$aWhile acute detrimental effects of benzodiazepine (BDZ), and BDZ and related z-substance (BDZR) use on cognition and memory are known, the association of BDZR use and risk of dementia in the elderly is controversially discussed. Previous studies on cohort or claims data mostly show an increased risk for dementia with the use of BDZs or BDZRs. For Germany, analyses on large population-based data sets are missing.To evaluate the association between regular BDZR use and incident any dementia in a large German claims data set.Using longitudinal German public health insurance data from 2004 to 2011 we analyzed the association between regular BDZR use (versus no BDZR use) and incident dementia in a case-control design. We examined patient samples aged≥60 years that were free of dementia at baseline. To address potential protopathic bias we introduced a lag time between BDZR prescription and dementia diagnosis. Odds ratios were calculated applying conditional logistic regression, adjusted for potential confounding factors such as comorbidities and polypharmacy.The regular use of BDZRs was associated with a significant increased risk of incident dementia for patients aged≥60 years (adjusted odds ratio [OR] 1.21, 95% confidence interval [CI] 1.13-1.29). The association was slightly stronger for long-acting substances than for short-acting ones. A trend for increased risk for dementia with higher exposure was observed.The restricted use of BDZRs may contribute to dementia prevention in the elderly.
000138797 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000138797 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x1
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000138797 650_7 $$012794-10-4$$2NLM Chemicals$$aBenzodiazepines
000138797 650_2 $$2MeSH$$aAged
000138797 650_2 $$2MeSH$$aAged, 80 and over
000138797 650_2 $$2MeSH$$aBenzodiazepines: adverse effects
000138797 650_2 $$2MeSH$$aBenzodiazepines: chemistry
000138797 650_2 $$2MeSH$$aCase-Control Studies
000138797 650_2 $$2MeSH$$aDementia: chemically induced
000138797 650_2 $$2MeSH$$aDementia: diagnosis
000138797 650_2 $$2MeSH$$aDementia: epidemiology
000138797 650_2 $$2MeSH$$aDrug Utilization: statistics & numerical data
000138797 650_2 $$2MeSH$$aDrug Utilization: trends
000138797 650_2 $$2MeSH$$aFemale
000138797 650_2 $$2MeSH$$aFollow-Up Studies
000138797 650_2 $$2MeSH$$aGermany: epidemiology
000138797 650_2 $$2MeSH$$aHumans
000138797 650_2 $$2MeSH$$aInsurance Claim Reporting: statistics & numerical data
000138797 650_2 $$2MeSH$$aInsurance Claim Reporting: trends
000138797 650_2 $$2MeSH$$aLongitudinal Studies
000138797 650_2 $$2MeSH$$aMale
000138797 650_2 $$2MeSH$$aMiddle Aged
000138797 650_2 $$2MeSH$$aRisk Factors
000138797 7001_ $$0P:(DE-2719)2810710$$avon Holt, Klaus$$b1$$udzne
000138797 7001_ $$0P:(DE-2719)2810705$$aThomé, Friederike$$b2$$udzne
000138797 7001_ $$aBroich, Karl$$b3
000138797 7001_ $$0P:(DE-2719)2000015$$aMaier, Wolfgang$$b4$$udzne
000138797 7001_ $$aWeckbecker, Klaus$$b5
000138797 7001_ $$0P:(DE-2719)2241493$$aFink, Anne$$b6$$udzne
000138797 7001_ $$0P:(DE-2719)2811246$$aDoblhammer-Reiter, Gabriele$$b7$$udzne
000138797 7001_ $$0P:(DE-2719)2810511$$aHaenisch, Britta$$b8$$eLast author$$udzne
000138797 77318 $$2Crossref$$3journal-article$$a10.3233/jad-151006$$b : IOS Press, 2016-09-06$$n2$$p801-808$$tJournal of Alzheimer's Disease$$v54$$x1387-2877$$y2016
000138797 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-151006$$gVol. 54, no. 2, p. 801 - 808$$n2$$p801-808$$q54:2<801 - 808$$tJournal of Alzheimer's disease$$v54$$x1387-2877$$y2016
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