TY  - JOUR
AU  - Gomm, Willy
AU  - von Holt, Klaus
AU  - Thomé, Friederike
AU  - Broich, Karl
AU  - Maier, Wolfgang
AU  - Weckbecker, Klaus
AU  - Fink, Anne
AU  - Doblhammer-Reiter, Gabriele
AU  - Haenisch, Britta
TI  - Regular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data.
JO  - Journal of Alzheimer's disease
VL  - 54
IS  - 2
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-05119
SP  - 801-808
PY  - 2016
AB  - While acute detrimental effects of benzodiazepine (BDZ), and BDZ and related z-substance (BDZR) use on cognition and memory are known, the association of BDZR use and risk of dementia in the elderly is controversially discussed. Previous studies on cohort or claims data mostly show an increased risk for dementia with the use of BDZs or BDZRs. For Germany, analyses on large population-based data sets are missing.To evaluate the association between regular BDZR use and incident any dementia in a large German claims data set.Using longitudinal German public health insurance data from 2004 to 2011 we analyzed the association between regular BDZR use (versus no BDZR use) and incident dementia in a case-control design. We examined patient samples aged≥60 years that were free of dementia at baseline. To address potential protopathic bias we introduced a lag time between BDZR prescription and dementia diagnosis. Odds ratios were calculated applying conditional logistic regression, adjusted for potential confounding factors such as comorbidities and polypharmacy.The regular use of BDZRs was associated with a significant increased risk of incident dementia for patients aged≥60 years (adjusted odds ratio [OR] 1.21, 95
KW  - Aged
KW  - Aged, 80 and over
KW  - Benzodiazepines: adverse effects
KW  - Benzodiazepines: chemistry
KW  - Case-Control Studies
KW  - Dementia: chemically induced
KW  - Dementia: diagnosis
KW  - Dementia: epidemiology
KW  - Drug Utilization: statistics & numerical data
KW  - Drug Utilization: trends
KW  - Female
KW  - Follow-Up Studies
KW  - Germany: epidemiology
KW  - Humans
KW  - Insurance Claim Reporting: statistics & numerical data
KW  - Insurance Claim Reporting: trends
KW  - Longitudinal Studies
KW  - Male
KW  - Middle Aged
KW  - Risk Factors
KW  - Benzodiazepines (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27567804
DO  - DOI:10.3233/JAD-151006
UR  - https://pub.dzne.de/record/138797
ER  -