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000138809 0247_ $$2doi$$a10.1073/pnas.1605256113
000138809 0247_ $$2pmid$$apmid:27671655
000138809 0247_ $$2pmc$$apmc:PMC5068320
000138809 0247_ $$2ISSN$$a0027-8424
000138809 0247_ $$2ISSN$$a1091-6490
000138809 037__ $$aDZNE-2020-05131
000138809 041__ $$aEnglish
000138809 082__ $$a500
000138809 1001_ $$aGrauel, M Katharina$$b0
000138809 245__ $$aRIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
000138809 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2016
000138809 264_1 $$2Crossref$$3online$$bProceedings of the National Academy of Sciences$$c2016-09-26
000138809 264_1 $$2Crossref$$3print$$bProceedings of the National Academy of Sciences$$c2016-10-11
000138809 3367_ $$2DRIVER$$aarticle
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000138809 3367_ $$2BibTeX$$aARTICLE
000138809 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000138809 520__ $$aThe tight spatial coupling of synaptic vesicles and voltage-gated Ca2+ channels (CaVs) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca2+ channels and via RIM with other components of the release machinery. Although human RIM-BPs have been implicated in autism spectrum disorders, little is known about the role of mammalian RIM-BPs in synaptic transmission. We investigated RIM-BP2-deficient murine hippocampal neurons in cultures and slices. Short-term facilitation is significantly enhanced in both model systems. Detailed analysis in culture revealed a reduction in initial release probability, which presumably underlies the increased short-term facilitation. Superresolution microscopy revealed an impairment in CaV2.1 clustering at AZs, which likely alters Ca2+ nanodomains at release sites and thereby affects release probability. Additional deletion of RIM-BP1 does not exacerbate the phenotype, indicating that RIM-BP2 is the dominating RIM-BP isoform at these synapses.
000138809 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000138809 542__ $$2Crossref$$i2016-09-26$$uhttp://www.pnas.org/site/misc/userlicense.xhtml
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000138809 650_7 $$2NLM Chemicals$$aCalcium Channels
000138809 650_7 $$0SY7Q814VUP$$2NLM Chemicals$$aCalcium
000138809 650_2 $$2MeSH$$aAction Potentials
000138809 650_2 $$2MeSH$$aAnimals
000138809 650_2 $$2MeSH$$aCalcium: metabolism
000138809 650_2 $$2MeSH$$aCalcium Channels: metabolism
000138809 650_2 $$2MeSH$$aCells, Cultured
000138809 650_2 $$2MeSH$$aElectrophysiological Phenomena
000138809 650_2 $$2MeSH$$aFemale
000138809 650_2 $$2MeSH$$aGene Deletion
000138809 650_2 $$2MeSH$$aGene Expression
000138809 650_2 $$2MeSH$$aGene Targeting
000138809 650_2 $$2MeSH$$aGenetic Loci
000138809 650_2 $$2MeSH$$aHippocampus: metabolism
000138809 650_2 $$2MeSH$$aMale
000138809 650_2 $$2MeSH$$aMice
000138809 650_2 $$2MeSH$$aMice, Knockout
000138809 650_2 $$2MeSH$$aNeurons: metabolism
000138809 650_2 $$2MeSH$$aPhenotype
000138809 650_2 $$2MeSH$$aProtein Transport
000138809 650_2 $$2MeSH$$aSynapses: metabolism
000138809 650_2 $$2MeSH$$aSynaptic Transmission: genetics
000138809 650_2 $$2MeSH$$aSynaptic Vesicles: metabolism
000138809 7001_ $$aMaglione, Marta$$b1
000138809 7001_ $$aReddy-Alla, Suneel$$b2
000138809 7001_ $$0P:(DE-HGF)0$$aWillmes, Claudia G$$b3
000138809 7001_ $$aBrockmann, Marisa M$$b4
000138809 7001_ $$aTrimbuch, Thorsten$$b5
000138809 7001_ $$aRosenmund, Tanja$$b6
000138809 7001_ $$aPangalos, Maria$$b7
000138809 7001_ $$aVardar, Gülçin$$b8
000138809 7001_ $$aStumpf, Alexander$$b9
000138809 7001_ $$aWalter, Alexander M$$b10
000138809 7001_ $$0P:(DE-2719)2810914$$aRost, Benjamin R$$b11$$udzne
000138809 7001_ $$aEickholt, Britta J$$b12
000138809 7001_ $$aHaucke, Volker$$b13
000138809 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b14$$udzne
000138809 7001_ $$0P:(DE-HGF)0$$aSigrist, Stephan J$$b15
000138809 7001_ $$0P:(DE-HGF)0$$aRosenmund, Christian$$b16$$eCorresponding author
000138809 77318 $$2Crossref$$3journal-article$$a10.1073/pnas.1605256113$$b : Proceedings of the National Academy of Sciences, 2016-09-26$$n41$$p11615-11620$$tProceedings of the National Academy of Sciences$$v113$$x0027-8424$$y2016
000138809 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.1605256113$$gVol. 113, no. 41, p. 11615 - 11620$$n41$$p11615-11620$$q113:41<11615 - 11620$$tProceedings of the National Academy of Sciences of the United States of America$$v113$$x0027-8424$$y2016
000138809 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068320
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000138809 9141_ $$y2016
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