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| 001 | 138809 | ||
| 005 | 20240321220512.0 | ||
| 024 | 7 | _ | |a 10.1073/pnas.1605256113 |2 doi |
| 024 | 7 | _ | |a pmid:27671655 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5068320 |2 pmc |
| 024 | 7 | _ | |a 0027-8424 |2 ISSN |
| 024 | 7 | _ | |a 1091-6490 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-05131 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Grauel, M Katharina |b 0 |
| 245 | _ | _ | |a RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. |
| 260 | _ | _ | |a Washington, DC |c 2016 |b National Acad. of Sciences |
| 264 | _ | 1 | |3 online |2 Crossref |b Proceedings of the National Academy of Sciences |c 2016-09-26 |
| 264 | _ | 1 | |3 print |2 Crossref |b Proceedings of the National Academy of Sciences |c 2016-10-11 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1586187515_18408 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The tight spatial coupling of synaptic vesicles and voltage-gated Ca2+ channels (CaVs) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca2+ channels and via RIM with other components of the release machinery. Although human RIM-BPs have been implicated in autism spectrum disorders, little is known about the role of mammalian RIM-BPs in synaptic transmission. We investigated RIM-BP2-deficient murine hippocampal neurons in cultures and slices. Short-term facilitation is significantly enhanced in both model systems. Detailed analysis in culture revealed a reduction in initial release probability, which presumably underlies the increased short-term facilitation. Superresolution microscopy revealed an impairment in CaV2.1 clustering at AZs, which likely alters Ca2+ nanodomains at release sites and thereby affects release probability. Additional deletion of RIM-BP1 does not exacerbate the phenotype, indicating that RIM-BP2 is the dominating RIM-BP isoform at these synapses. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2016-09-26 |2 Crossref |u http://www.pnas.org/site/misc/userlicense.xhtml |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Calcium Channels |2 NLM Chemicals |
| 650 | _ | 7 | |a Calcium |0 SY7Q814VUP |2 NLM Chemicals |
| 650 | _ | 2 | |a Action Potentials |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Calcium: metabolism |2 MeSH |
| 650 | _ | 2 | |a Calcium Channels: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Electrophysiological Phenomena |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Gene Deletion |2 MeSH |
| 650 | _ | 2 | |a Gene Expression |2 MeSH |
| 650 | _ | 2 | |a Gene Targeting |2 MeSH |
| 650 | _ | 2 | |a Genetic Loci |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: metabolism |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Phenotype |2 MeSH |
| 650 | _ | 2 | |a Protein Transport |2 MeSH |
| 650 | _ | 2 | |a Synapses: metabolism |2 MeSH |
| 650 | _ | 2 | |a Synaptic Transmission: genetics |2 MeSH |
| 650 | _ | 2 | |a Synaptic Vesicles: metabolism |2 MeSH |
| 700 | 1 | _ | |a Maglione, Marta |b 1 |
| 700 | 1 | _ | |a Reddy-Alla, Suneel |b 2 |
| 700 | 1 | _ | |a Willmes, Claudia G |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Brockmann, Marisa M |b 4 |
| 700 | 1 | _ | |a Trimbuch, Thorsten |b 5 |
| 700 | 1 | _ | |a Rosenmund, Tanja |b 6 |
| 700 | 1 | _ | |a Pangalos, Maria |b 7 |
| 700 | 1 | _ | |a Vardar, Gülçin |b 8 |
| 700 | 1 | _ | |a Stumpf, Alexander |b 9 |
| 700 | 1 | _ | |a Walter, Alexander M |b 10 |
| 700 | 1 | _ | |a Rost, Benjamin R |0 P:(DE-2719)2810914 |b 11 |u dzne |
| 700 | 1 | _ | |a Eickholt, Britta J |b 12 |
| 700 | 1 | _ | |a Haucke, Volker |b 13 |
| 700 | 1 | _ | |a Schmitz, Dietmar |0 P:(DE-2719)2810725 |b 14 |u dzne |
| 700 | 1 | _ | |a Sigrist, Stephan J |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Rosenmund, Christian |0 P:(DE-HGF)0 |b 16 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1073/pnas.1605256113 |b : Proceedings of the National Academy of Sciences, 2016-09-26 |n 41 |p 11615-11620 |3 journal-article |2 Crossref |t Proceedings of the National Academy of Sciences |v 113 |y 2016 |x 0027-8424 |
| 773 | _ | _ | |a 10.1073/pnas.1605256113 |g Vol. 113, no. 41, p. 11615 - 11620 |0 PERI:(DE-600)1461794-8 |n 41 |q 113:41<11615 - 11620 |p 11615-11620 |t Proceedings of the National Academy of Sciences of the United States of America |v 113 |y 2016 |x 0027-8424 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068320 |
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