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000138817 0247_ $$2doi$$a10.1038/nmeth.3964
000138817 0247_ $$2pmid$$apmid:27548807
000138817 0247_ $$2ISSN$$a1548-7091
000138817 0247_ $$2ISSN$$a1548-7105
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000138817 037__ $$aDZNE-2020-05139
000138817 041__ $$aEnglish
000138817 082__ $$a610
000138817 1001_ $$0P:(DE-HGF)0$$aPan, Chenchen$$b0
000138817 245__ $$aShrinkage-mediated imaging of entire organs and organisms using uDISCO.
000138817 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2016
000138817 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2016-08-22
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000138817 520__ $$aRecent tissue-clearing approaches have become important alternatives to standard histology approaches. However, light scattering in thick tissues and the size restrictions on samples that can be imaged with standard light-sheet microscopy pose limitations for analyzing large samples such as an entire rodent body. We developed 'ultimate DISCO' (uDISCO) clearing to overcome these limitations in volumetric imaging. uDISCO preserves fluorescent proteins over months and renders intact organs and rodent bodies transparent while reducing their size up to 65%. We used uDISCO to image neuronal connections and vasculature from head to toe over 7 cm and to perform unbiased screening of transplanted stem cells within the entire body of adult mice. uDISCO is compatible with diverse labeling methods and archival human tissue, and it can readily be used in various biomedical applications to study organization of large organ systems throughout entire organisms.
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000138817 650_7 $$2NLM Chemicals$$aContrast Media
000138817 650_7 $$2NLM Chemicals$$aPhenyl Ethers
000138817 650_7 $$2NLM Chemicals$$aSolvents
000138817 650_7 $$0147336-22-9$$2NLM Chemicals$$aGreen Fluorescent Proteins
000138817 650_7 $$03O695R5M1U$$2NLM Chemicals$$aphenyl ether
000138817 650_2 $$2MeSH$$aAnimals
000138817 650_2 $$2MeSH$$aCentral Nervous System: blood supply
000138817 650_2 $$2MeSH$$aCentral Nervous System: cytology
000138817 650_2 $$2MeSH$$aContrast Media
000138817 650_2 $$2MeSH$$aFemale
000138817 650_2 $$2MeSH$$aGreen Fluorescent Proteins: analysis
000138817 650_2 $$2MeSH$$aGreen Fluorescent Proteins: chemistry
000138817 650_2 $$2MeSH$$aGreen Fluorescent Proteins: genetics
000138817 650_2 $$2MeSH$$aHalf-Life
000138817 650_2 $$2MeSH$$aHumans
000138817 650_2 $$2MeSH$$aImaging, Three-Dimensional: methods
000138817 650_2 $$2MeSH$$aImmunohistochemistry: methods
000138817 650_2 $$2MeSH$$aMale
000138817 650_2 $$2MeSH$$aMice, Inbred C57BL
000138817 650_2 $$2MeSH$$aMice, Transgenic
000138817 650_2 $$2MeSH$$aMicroscopy, Fluorescence: methods
000138817 650_2 $$2MeSH$$aNeuroimaging: methods
000138817 650_2 $$2MeSH$$aOrgan Specificity
000138817 650_2 $$2MeSH$$aPhenyl Ethers: chemistry
000138817 650_2 $$2MeSH$$aRats
000138817 650_2 $$2MeSH$$aSingle-Cell Analysis: methods
000138817 650_2 $$2MeSH$$aSolvents: chemistry
000138817 650_2 $$2MeSH$$aStaining and Labeling
000138817 650_2 $$2MeSH$$aWhole Body Imaging: methods
000138817 7001_ $$0P:(DE-HGF)0$$aCai, Ruiyao$$b1
000138817 7001_ $$0P:(DE-HGF)0$$aQuacquarelli, Francesca Paola$$b2
000138817 7001_ $$0P:(DE-HGF)0$$aGhasemigharagoz, Alireza$$b3
000138817 7001_ $$0P:(DE-HGF)0$$aLourbopoulos, Athanasios$$b4
000138817 7001_ $$0P:(DE-HGF)0$$aMatryba, Paweł$$b5
000138817 7001_ $$0P:(DE-HGF)0$$aPlesnila, Nikolaus$$b6
000138817 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b7$$udzne
000138817 7001_ $$0P:(DE-HGF)0$$aHellal, Farida$$b8
000138817 7001_ $$0P:(DE-HGF)0$$aErtürk, Ali$$b9$$eCorresponding author
000138817 77318 $$2Crossref$$3journal-article$$a10.1038/nmeth.3964$$b : Springer Science and Business Media LLC, 2016-08-22$$n10$$p859-867$$tNature Methods$$v13$$x1548-7091$$y2016
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