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000138831 0247_ $$2doi$$a10.1016/j.cub.2016.07.081
000138831 0247_ $$2pmid$$apmid:27666968
000138831 0247_ $$2ISSN$$a0960-9822
000138831 0247_ $$2ISSN$$a1879-0445
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000138831 037__ $$aDZNE-2020-05153
000138831 041__ $$aEnglish
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000138831 1001_ $$0P:(DE-HGF)0$$aBaker, Stevenson$$b0$$eCorresponding author
000138831 245__ $$aThe Human Dentate Gyrus Plays a Necessary Role in Discriminating New Memories.
000138831 260__ $$aLondon$$bCurrent Biology Ltd.$$c2016
000138831 264_1 $$2Crossref$$3print$$bElsevier BV$$c2016-10-01
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000138831 520__ $$aOur day-to-day experiences are often similar to one another, occurring in the same place at the same time of day, with common people and objects, and with a shared purpose. Humans have an episodic memory to represent unique, personal events that are rich in detail [1]. For this to occur, at least two basic neural mechanisms are required: one to orthogonalize or 'separate' overlapping input patterns at encoding and another to reinstate or 'complete' memories from partial cues at retrieval [2-6]. To what extent do these purported 'pattern separation' and 'pattern completion' mechanisms rely on distinct subfields of the hippocampus [6]? Computational models [4-6] and lesion and genetic studies in rodents [7-12] largely point to the dentate gyrus as responsible for pattern separation and the CA3 and CA1 subfields for pattern completion (but see [13-16]). In high-resolution fMRI studies of humans, behavioral discrimination and completion tasks designed to approximate pattern separation and pattern completion, respectively, elicit the predicted pattern of activity in the dentate gyrus and CA3/CA1 [17-21]. Likewise, impaired behavioral discrimination has been demonstrated in individuals with hippocampal lesions [22, 23], but the lesions most likely encompass other subfields. Examination of these processes in individuals with selective lesions to hippocampal subfields is needed to infer causation [19]. Here, we report the rare case of BL, a 54-year-old man with bilateral ischemic lesions to the hippocampus [24] primarily affecting the dentate gyrus. Studying BL provides the unique opportunity to directly evaluate theories of hippocampal function that assign the dentate gyrus a specific role in discriminating old from new memories.
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000138831 542__ $$2Crossref$$i2017-10-10$$uhttp://www.elsevier.com/open-access/userlicense/1.0/
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000138831 650_2 $$2MeSH$$aDentate Gyrus: pathology
000138831 650_2 $$2MeSH$$aDentate Gyrus: physiology
000138831 650_2 $$2MeSH$$aHumans
000138831 650_2 $$2MeSH$$aMale
000138831 650_2 $$2MeSH$$aMemory Disorders: physiopathology
000138831 650_2 $$2MeSH$$aMemory, Episodic
000138831 650_2 $$2MeSH$$aMiddle Aged
000138831 7001_ $$0P:(DE-2719)2810529$$aVieweg, Paula$$b1$$udzne
000138831 7001_ $$0P:(DE-HGF)0$$aGao, Fuqiang$$b2
000138831 7001_ $$0P:(DE-HGF)0$$aGilboa, Asaf$$b3
000138831 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b4$$udzne
000138831 7001_ $$0P:(DE-HGF)0$$aBlack, Sandra E$$b5
000138831 7001_ $$0P:(DE-HGF)0$$aRosenbaum, R Shayna$$b6
000138831 77318 $$2Crossref$$3journal-article$$a10.1016/j.cub.2016.07.081$$b : Elsevier BV, 2016-10-01$$n19$$p2629-2634$$tCurrent Biology$$v26$$x0960-9822$$y2016
000138831 773__ $$0PERI:(DE-600)2019214-9$$a10.1016/j.cub.2016.07.081$$gVol. 26, no. 19, p. 2629 - 2634$$n19$$p2629-2634$$q26:19<2629 - 2634$$tCurrent biology$$v26$$x0960-9822$$y2016
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