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@ARTICLE{Baker:138831,
      author       = {Baker, Stevenson and Vieweg, Paula and Gao, Fuqiang and
                      Gilboa, Asaf and Wolbers, Thomas and Black, Sandra E and
                      Rosenbaum, R Shayna},
      title        = {{T}he {H}uman {D}entate {G}yrus {P}lays a {N}ecessary
                      {R}ole in {D}iscriminating {N}ew {M}emories.},
      journal      = {Current biology},
      volume       = {26},
      number       = {19},
      issn         = {0960-9822},
      address      = {London},
      publisher    = {Current Biology Ltd.},
      reportid     = {DZNE-2020-05153},
      pages        = {2629-2634},
      year         = {2016},
      abstract     = {Our day-to-day experiences are often similar to one
                      another, occurring in the same place at the same time of
                      day, with common people and objects, and with a shared
                      purpose. Humans have an episodic memory to represent unique,
                      personal events that are rich in detail [1]. For this to
                      occur, at least two basic neural mechanisms are required:
                      one to orthogonalize or 'separate' overlapping input
                      patterns at encoding and another to reinstate or 'complete'
                      memories from partial cues at retrieval [2-6]. To what
                      extent do these purported 'pattern separation' and 'pattern
                      completion' mechanisms rely on distinct subfields of the
                      hippocampus [6]? Computational models [4-6] and lesion and
                      genetic studies in rodents [7-12] largely point to the
                      dentate gyrus as responsible for pattern separation and the
                      CA3 and CA1 subfields for pattern completion (but see
                      [13-16]). In high-resolution fMRI studies of humans,
                      behavioral discrimination and completion tasks designed to
                      approximate pattern separation and pattern completion,
                      respectively, elicit the predicted pattern of activity in
                      the dentate gyrus and CA3/CA1 [17-21]. Likewise, impaired
                      behavioral discrimination has been demonstrated in
                      individuals with hippocampal lesions [22, 23], but the
                      lesions most likely encompass other subfields. Examination
                      of these processes in individuals with selective lesions to
                      hippocampal subfields is needed to infer causation [19].
                      Here, we report the rare case of BL, a 54-year-old man with
                      bilateral ischemic lesions to the hippocampus [24] primarily
                      affecting the dentate gyrus. Studying BL provides the unique
                      opportunity to directly evaluate theories of hippocampal
                      function that assign the dentate gyrus a specific role in
                      discriminating old from new memories.},
      keywords     = {Dentate Gyrus: pathology / Dentate Gyrus: physiology /
                      Humans / Male / Memory Disorders: physiopathology / Memory,
                      Episodic / Middle Aged},
      cin          = {AG Wolbers},
      ddc          = {570},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27666968},
      doi          = {10.1016/j.cub.2016.07.081},
      url          = {https://pub.dzne.de/record/138831},
}