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000138852 0247_ $$2doi$$a10.1186/s40478-016-0381-9
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000138852 037__ $$aDZNE-2020-05174
000138852 041__ $$aEnglish
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000138852 1001_ $$0P:(DE-2719)2812690$$aMazzitelli, Sonia$$b0$$eFirst author$$udzne
000138852 245__ $$aAmyloid-β 1-24 C-terminal truncated fragment promotes amyloid-β 1-42 aggregate formation in the healthy brain.
000138852 260__ $$aLondon$$bBiomed Central$$c2016
000138852 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2016-10-10
000138852 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2016-12-01
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000138852 520__ $$aSubstantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer's Disease and indeed the assembly of naturally occurring amyloid peptides into cytotoxic aggregates is linked to the disease pathogenesis. Although Aβ42 is a highly aggregating form of Aβ, the co-occurrence of shorter Aβ peptides might affect the aggregation potential of the Aβ pool. In this study we aimed to assess whether the structural behavior of human Aβ42 peptide inside the brain is influenced by the concomitant presence of N-terminal fragments produced by the proteolytic activity of glial cells. We show that the occurrence of the human C-terminal truncated 1-24 Aβ fragment impairs Aβ42 clearance through blood brain barrier and promotes the formation of Aβ42 aggregates even in the healthy brain. By showing that Aβ1-24 has seeding properties for aggregate formation in intracranially injected wild type mice, our study provide the proof-of-concept that peptides produced upon Aβ42 cleavage by activated glial cells may cause phenotypic defects even in the absence of genetic mutations associated with Alzheimer's Disease, possibly contributing to the development of the sporadic form of the pathology.
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000138852 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000138852 650_7 $$2NLM Chemicals$$aPeptide Fragments
000138852 650_7 $$2NLM Chemicals$$aamyloid beta-peptide (1-24)
000138852 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-42)
000138852 650_7 $$0EC 3.4.24.35$$2NLM Chemicals$$aMatrix Metalloproteinase 9
000138852 650_7 $$0EC 3.4.24.35$$2NLM Chemicals$$aMmp9 protein, mouse
000138852 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000138852 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000138852 650_2 $$2MeSH$$aAmyloid beta-Peptides: administration & dosage
000138852 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000138852 650_2 $$2MeSH$$aAnimals
000138852 650_2 $$2MeSH$$aBrain: metabolism
000138852 650_2 $$2MeSH$$aBrain: pathology
000138852 650_2 $$2MeSH$$aDisease Models, Animal
000138852 650_2 $$2MeSH$$aHumans
000138852 650_2 $$2MeSH$$aLearning Disabilities: metabolism
000138852 650_2 $$2MeSH$$aLearning Disabilities: pathology
000138852 650_2 $$2MeSH$$aMatrix Metalloproteinase 9: genetics
000138852 650_2 $$2MeSH$$aMatrix Metalloproteinase 9: metabolism
000138852 650_2 $$2MeSH$$aMemory Disorders: metabolism
000138852 650_2 $$2MeSH$$aMemory Disorders: pathology
000138852 650_2 $$2MeSH$$aMice
000138852 650_2 $$2MeSH$$aMice, Inbred BALB C
000138852 650_2 $$2MeSH$$aMice, Inbred C57BL
000138852 650_2 $$2MeSH$$aMice, Knockout
000138852 650_2 $$2MeSH$$aMice, Transgenic
000138852 650_2 $$2MeSH$$aMicroglia: metabolism
000138852 650_2 $$2MeSH$$aMicroglia: pathology
000138852 650_2 $$2MeSH$$aMotor Activity: physiology
000138852 650_2 $$2MeSH$$aPeptide Fragments: administration & dosage
000138852 650_2 $$2MeSH$$aPeptide Fragments: metabolism
000138852 650_2 $$2MeSH$$aPlaque, Amyloid: metabolism
000138852 650_2 $$2MeSH$$aPlaque, Amyloid: pathology
000138852 650_2 $$2MeSH$$aProtein Folding
000138852 650_2 $$2MeSH$$aProtein Multimerization
000138852 650_2 $$2MeSH$$aSocial Behavior
000138852 7001_ $$aFilipello, Fabia$$b1
000138852 7001_ $$aRasile, Marco$$b2
000138852 7001_ $$aLauranzano, Eliana$$b3
000138852 7001_ $$aStarvaggi-Cucuzza, Chiara$$b4
000138852 7001_ $$aTamborini, Matteo$$b5
000138852 7001_ $$aPozzi, Davide$$b6
000138852 7001_ $$aBarajon, Isabella$$b7
000138852 7001_ $$aGiorgino, Toni$$b8
000138852 7001_ $$aNatalello, Antonino$$b9
000138852 7001_ $$0P:(DE-HGF)0$$aMatteoli, Michela$$b10$$eCorresponding author
000138852 77318 $$2Crossref$$3journal-article$$a10.1186/s40478-016-0381-9$$b : Springer Science and Business Media LLC, 2016-10-10$$n1$$p110$$tActa Neuropathologica Communications$$v4$$x2051-5960$$y2016
000138852 773__ $$0PERI:(DE-600)2715589-4$$a10.1186/s40478-016-0381-9$$gVol. 4, no. 1, p. 110$$n1$$p110$$q4:1<110$$tActa Neuropathologica Communications$$v4$$x2051-5960$$y2016
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000138852 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057504
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.222681699$$o10.1073/pnas.222681699
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jmb.2006.09.046$$o10.1016/j.jmb.2006.09.046
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00018-014-1634-z$$o10.1007/s00018-014-1634-z
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/emboj.2010.211$$o10.1038/emboj.2010.211
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.20-10-03606.2000$$o10.1523/JNEUROSCI.20-10-03606.2000
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1131864$$o10.1126/science.1131864
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0903200106$$o10.1073/pnas.0903200106
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nbd.2014.08.031$$o10.1016/j.nbd.2014.08.031
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0014-5793(94)00387-4$$o10.1016/0014-5793(94)00387-4
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.16-24-07910.1996$$o10.1523/JNEUROSCI.16-24-07910.1996
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0400924101$$o10.1073/pnas.0400924101
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M602440200$$o10.1074/jbc.M602440200
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0901085106$$o10.1073/pnas.0901085106
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.18-20-08311.1998$$o10.1523/JNEUROSCI.18-20-08311.1998
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1046/j.1471-4159.1996.66041641.x$$o10.1046/j.1471-4159.1996.66041641.x
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2085-06.2006$$o10.1523/JNEUROSCI.2085-06.2006
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/embor.2011.116$$o10.1038/embor.2011.116
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbapap.2010.04.001$$o10.1016/j.bbapap.2010.04.001
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jsb.2005.06.006$$o10.1016/j.jsb.2005.06.006
000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2006.02.012$$o10.1016/j.neurobiolaging.2006.02.012
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/01.WNL.0000103288.49441.E4$$o10.1212/01.WNL.0000103288.49441.E4
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000138852 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1072994$$o10.1126/science.1072994
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000138852 999C5 $$2Crossref$$oRM Rodriguiz Animal Models of Cognitive Impairment 2006$$tAnimal Models of Cognitive Impairment$$y2006
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