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000138857 0247_ $$2doi$$a10.1016/j.neuron.2016.09.026
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000138857 037__ $$aDZNE-2020-05179
000138857 041__ $$aEnglish
000138857 082__ $$a610
000138857 1001_ $$0P:(DE-2719)2810470$$aTedeschi, Andrea$$b0$$eFirst author
000138857 245__ $$aThe Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.
000138857 260__ $$aNew York, NY$$bElsevier$$c2016
000138857 264_1 $$2Crossref$$3print$$bElsevier BV$$c2016-10-01
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000138857 520__ $$aInjuries to the adult CNS often result in permanent disabilities because neurons lose the ability to regenerate their axon during development. Here, whole transcriptome sequencing and bioinformatics analysis followed by gain- and loss-of-function experiments identified Cacna2d2, the gene encoding the Alpha2delta2 subunit of voltage-gated calcium channels (VGCCs), as a developmental switch that limits axon growth and regeneration. Cacna2d2 gene deletion or silencing promoted axon growth in vitro. In vivo, Alpha2delta2 pharmacological blockade through Pregabalin (PGB) administration enhanced axon regeneration in adult mice after spinal cord injury (SCI). As PGB is already an established treatment for a wide range of neurological disorders, our findings suggest that targeting Alpha2delta2 may be a novel treatment strategy to promote structural plasticity and regeneration following CNS trauma.
000138857 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000138857 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x1
000138857 542__ $$2Crossref$$i2016-10-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000138857 542__ $$2Crossref$$i2017-10-19$$uhttps://www.elsevier.com/open-access/userlicense/1.0/
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000138857 650_7 $$2NLM Chemicals$$aCacna2d2 protein, mouse
000138857 650_7 $$2NLM Chemicals$$aCalcium Channel Blockers
000138857 650_7 $$2NLM Chemicals$$aCalcium Channels
000138857 650_7 $$2NLM Chemicals$$aRNA, Messenger
000138857 650_7 $$055JG375S6M$$2NLM Chemicals$$aPregabalin
000138857 650_2 $$2MeSH$$aAnimals
000138857 650_2 $$2MeSH$$aAxons: drug effects
000138857 650_2 $$2MeSH$$aAxons: physiology
000138857 650_2 $$2MeSH$$aCalcium Channel Blockers: pharmacology
000138857 650_2 $$2MeSH$$aCalcium Channels: drug effects
000138857 650_2 $$2MeSH$$aCalcium Channels: genetics
000138857 650_2 $$2MeSH$$aCalcium Channels: metabolism
000138857 650_2 $$2MeSH$$aCentral Nervous System
000138857 650_2 $$2MeSH$$aFemale
000138857 650_2 $$2MeSH$$aGanglia, Spinal: cytology
000138857 650_2 $$2MeSH$$aGanglia, Spinal: metabolism
000138857 650_2 $$2MeSH$$aGene Expression Profiling
000138857 650_2 $$2MeSH$$aMice
000138857 650_2 $$2MeSH$$aMice, Inbred C57BL
000138857 650_2 $$2MeSH$$aMice, Knockout
000138857 650_2 $$2MeSH$$aNeuronal Outgrowth: drug effects
000138857 650_2 $$2MeSH$$aNeuronal Outgrowth: genetics
000138857 650_2 $$2MeSH$$aNeurons: metabolism
000138857 650_2 $$2MeSH$$aPregabalin: pharmacology
000138857 650_2 $$2MeSH$$aRNA, Messenger: metabolism
000138857 650_2 $$2MeSH$$aRegeneration: drug effects
000138857 650_2 $$2MeSH$$aRegeneration: genetics
000138857 650_2 $$2MeSH$$aSequence Analysis, RNA
000138857 650_2 $$2MeSH$$aSpinal Cord Injuries: metabolism
000138857 693__ $$0EXP:(DE-2719)PRECISE-20190321$$5EXP:(DE-2719)PRECISE-20190321$$ePlatform for Single Cell Genomics and Epigenomics at DZNE  University of Bonn$$x0
000138857 7001_ $$0P:(DE-2719)2810386$$aDupraz, Sebastian$$b1
000138857 7001_ $$0P:(DE-2719)2810278$$aLaskowski, Claudia J$$b2
000138857 7001_ $$0P:(DE-HGF)0$$aXue, Jia$$b3
000138857 7001_ $$0P:(DE-HGF)0$$aUlas, Thomas$$b4
000138857 7001_ $$0P:(DE-HGF)0$$aBeyer, Marc$$b5
000138857 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b6
000138857 7001_ $$0P:(DE-2719)2810270$$aBradke, Frank$$b7$$eLast author
000138857 77318 $$2Crossref$$3journal-article$$a10.1016/j.neuron.2016.09.026$$b : Elsevier BV, 2016-10-01$$n2$$p419-434$$tNeuron$$v92$$x0896-6273$$y2016
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000138857 8564_ $$uhttps://www.sciencedirect.com/science/article/pii/S0896627316305852?via%3Dihub
000138857 8564_ $$uhttps://pub.dzne.de/record/138857/files/DZNE-2020-05179_Restricted.pdf
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