Home > Publications Database > The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. > print

001     138857
005     20240321220518.0
024 7 _ |a 10.1016/j.neuron.2016.09.026
|2 doi
024 7 _ |a pmid:27720483
|2 pmid
024 7 _ |a 0896-6273
|2 ISSN
024 7 _ |a 1097-4199
|2 ISSN
024 7 _ |a altmetric:12487752
|2 altmetric
037 _ _ |a DZNE-2020-05179
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Tedeschi, Andrea
|0 P:(DE-2719)2810470
|b 0
|e First author
245 _ _ |a The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.
260 _ _ |a New York, NY
|c 2016
|b Elsevier
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2016-10-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1710341612_30566
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Injuries to the adult CNS often result in permanent disabilities because neurons lose the ability to regenerate their axon during development. Here, whole transcriptome sequencing and bioinformatics analysis followed by gain- and loss-of-function experiments identified Cacna2d2, the gene encoding the Alpha2delta2 subunit of voltage-gated calcium channels (VGCCs), as a developmental switch that limits axon growth and regeneration. Cacna2d2 gene deletion or silencing promoted axon growth in vitro. In vivo, Alpha2delta2 pharmacological blockade through Pregabalin (PGB) administration enhanced axon regeneration in adult mice after spinal cord injury (SCI). As PGB is already an established treatment for a wide range of neurological disorders, our findings suggest that targeting Alpha2delta2 may be a novel treatment strategy to promote structural plasticity and regeneration following CNS trauma.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
|0 G:(DE-HGF)POF3-341
|c POF3-341
|f POF III
|x 0
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 1
542 _ _ |i 2016-10-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2017-10-19
|2 Crossref
|u https://www.elsevier.com/open-access/userlicense/1.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Cacna2d2 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Calcium Channel Blockers
|2 NLM Chemicals
650 _ 7 |a Calcium Channels
|2 NLM Chemicals
650 _ 7 |a RNA, Messenger
|2 NLM Chemicals
650 _ 7 |a Pregabalin
|0 55JG375S6M
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Axons: drug effects
|2 MeSH
650 _ 2 |a Axons: physiology
|2 MeSH
650 _ 2 |a Calcium Channel Blockers: pharmacology
|2 MeSH
650 _ 2 |a Calcium Channels: drug effects
|2 MeSH
650 _ 2 |a Calcium Channels: genetics
|2 MeSH
650 _ 2 |a Calcium Channels: metabolism
|2 MeSH
650 _ 2 |a Central Nervous System
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Ganglia, Spinal: cytology
|2 MeSH
650 _ 2 |a Ganglia, Spinal: metabolism
|2 MeSH
650 _ 2 |a Gene Expression Profiling
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Neuronal Outgrowth: drug effects
|2 MeSH
650 _ 2 |a Neuronal Outgrowth: genetics
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Pregabalin: pharmacology
|2 MeSH
650 _ 2 |a RNA, Messenger: metabolism
|2 MeSH
650 _ 2 |a Regeneration: drug effects
|2 MeSH
650 _ 2 |a Regeneration: genetics
|2 MeSH
650 _ 2 |a Sequence Analysis, RNA
|2 MeSH
650 _ 2 |a Spinal Cord Injuries: metabolism
|2 MeSH
693 _ _ |0 EXP:(DE-2719)PRECISE-20190321
|5 EXP:(DE-2719)PRECISE-20190321
|e Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn
|x 0
700 1 _ |a Dupraz, Sebastian
|0 P:(DE-2719)2810386
|b 1
700 1 _ |a Laskowski, Claudia J
|0 P:(DE-2719)2810278
|b 2
700 1 _ |a Xue, Jia
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Ulas, Thomas
|0 P:(DE-HGF)0
|b 4
700 1 _ |a Beyer, Marc
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Schultze, Joachim L
|0 P:(DE-2719)2811660
|b 6
700 1 _ |a Bradke, Frank
|0 P:(DE-2719)2810270
|b 7
|e Last author
773 1 8 |a 10.1016/j.neuron.2016.09.026
|b : Elsevier BV, 2016-10-01
|n 2
|p 419-434
|3 journal-article
|2 Crossref
|t Neuron
|v 92
|y 2016
|x 0896-6273
773 _ _ |a 10.1016/j.neuron.2016.09.026
|g Vol. 92, no. 2, p. 419 - 434
|0 PERI:(DE-600)2001944-0
|n 2
|q 92:2<419 - 434
|p 419-434
|t Neuron
|v 92
|y 2016
|x 0896-6273
856 4 _ |u https://www.sciencedirect.com/science/article/pii/S0896627316305852?via%3Dihub
856 4 _ |u https://pub.dzne.de/record/138857/files/DZNE-2020-05179_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/138857/files/DZNE-2020-05179_Restricted.pdf?subformat=pdfa
|x pdfa
909 C O |p VDB
|o oai:pub.dzne.de:138857
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2810470
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)2810386
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2810278
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 6
|6 P:(DE-2719)2811660
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 7
|6 P:(DE-2719)2810270
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-341
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Molecular Signaling
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms and Model Systems
|x 1
914 1 _ |y 2016
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NEURON : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a IF >= 10
|0 StatID:(DE-HGF)9910
|2 StatID
|b NEURON : 2017
920 1 _ |0 I:(DE-2719)1013002
|k AG Bradke
|l Axon Growth and Regeneration
|x 0
920 1 _ |0 I:(DE-2719)1013031
|k Schultze - PRECISE
|l Platform for Single Cell Genomics and Epigenomics
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1013002
980 _ _ |a I:(DE-2719)1013031
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21