000138871 001__ 138871
000138871 005__ 20240109100304.0
000138871 0247_ $$2doi$$a10.1007/s00115-015-0041-5
000138871 0247_ $$2pmid$$apmid:26781314
000138871 0247_ $$2ISSN$$a0028-2804
000138871 0247_ $$2ISSN$$a1433-0407
000138871 037__ $$aDZNE-2020-05193
000138871 041__ $$ager
000138871 082__ $$a610
000138871 1001_ $$0P:(DE-HGF)0$$aBusche, M. A.$$b0$$eCorresponding author
000138871 245__ $$a[Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets].
000138871 260__ $$aHeidelberg$$bSpringer$$c2016
000138871 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2016-01-19
000138871 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2016-11-01
000138871 3367_ $$2DRIVER$$aarticle
000138871 3367_ $$2DataCite$$aOutput Types/Journal article
000138871 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1704790753_29466$$xReview Article
000138871 3367_ $$2BibTeX$$aARTICLE
000138871 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000138871 3367_ $$00$$2EndNote$$aJournal Article
000138871 520__ $$aAlzheimer's disease (AD) is characterized by the pathological accumulation of amyloid-beta (Abeta) and tau peptides in the brain. Recent evidence suggests that the soluble peptide amyloid-eta (Aeta) may have an additional role in the pathogenesis of AD. The detailed investigation of the cellular and neurophysiological mechanisms underlying AD has revealed surprising results that may become highly relevant for the early diagnosis and treatment of the disease. By analyzing the function of single neurons and large-scale networks in intact brains in vivo it has been shown that A-beta, tau and A-eta abnormally modulate brain activity and obviously unfold contrasting effects: while A-beta promotes neuronal hyperactivity as well as epileptiform activity, tau and A-eta reduce the activity of neurons. Promising new evidence from animal studies and humans with AD indicates that the treatment of hyperactivity may improve cognitive dysfunctions and even slow the underlying disease process.
000138871 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000138871 542__ $$2Crossref$$i2016-01-19$$uhttp://www.springer.com/tdm
000138871 588__ $$aDataset connected to CrossRef, PubMed,
000138871 650_2 $$2MeSH$$aAlzheimer Disease: complications
000138871 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000138871 650_2 $$2MeSH$$aAlzheimer Disease: therapy
000138871 650_2 $$2MeSH$$aBrain: physiopathology
000138871 650_2 $$2MeSH$$aEvidence-Based Medicine
000138871 650_2 $$2MeSH$$aHumans
000138871 650_2 $$2MeSH$$aPsychomotor Agitation: complications
000138871 650_2 $$2MeSH$$aPsychomotor Agitation: physiopathology
000138871 650_2 $$2MeSH$$aPsychomotor Agitation: therapy
000138871 650_2 $$2MeSH$$aTreatment Outcome
000138871 7001_ $$0P:(DE-HGF)0$$aStaufenbiel, M.$$b1
000138871 7001_ $$0P:(DE-2719)9000433$$aWillem, M.$$b2$$udzne
000138871 7001_ $$0P:(DE-2719)2202037$$aHaass, C.$$b3$$udzne
000138871 7001_ $$aFörstl, H.$$b4
000138871 77318 $$2Crossref$$3journal-article$$a10.1007/s00115-015-0041-5$$b : Springer Science and Business Media LLC, 2016-01-19$$n11$$p1163-1174$$tDer Nervenarzt$$v87$$x0028-2804$$y2016
000138871 773__ $$0PERI:(DE-600)1462945-8$$a10.1007/s00115-015-0041-5$$gVol. 87, no. 11, p. 1163 - 1174$$n11$$p1163-1174$$q87:11<1163 - 1174$$tDer Nervenarzt$$v87$$x0028-2804$$y2016
000138871 8564_ $$uhttps://pub.dzne.de/record/138871/files/DZNE-2020-05193.pdf
000138871 8564_ $$uhttps://pub.dzne.de/record/138871/files/DZNE-2020-05193.pdf?subformat=pdfa$$xpdfa
000138871 909CO $$ooai:pub.dzne.de:138871$$pVDB
000138871 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000433$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000138871 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2202037$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000138871 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000138871 9141_ $$y2016
000138871 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000138871 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNERVENARZT : 2017
000138871 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000138871 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000138871 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000138871 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000138871 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000138871 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000138871 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000138871 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000138871 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000138871 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000138871 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000138871 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000138871 9201_ $$0I:(DE-2719)5000048$$kExt LMU$$lExt Ludwig-Maximilians-University$$x0
000138871 9201_ $$0I:(DE-2719)1110007$$kAG Haass$$lMolecular Neurodegeneration$$x1
000138871 980__ $$ajournal
000138871 980__ $$aVDB
000138871 980__ $$aI:(DE-2719)5000048
000138871 980__ $$aI:(DE-2719)1110007
000138871 980__ $$aUNRESTRICTED
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.2433$$o10.1038/nn.2433
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1528-1167.2006.00554.x$$o10.1111/j.1528-1167.2006.00554.x
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4040-10.2010$$o10.1523/JNEUROSCI.4040-10.2010
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nicl.2015.02.009$$o10.1016/j.nicl.2015.02.009
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2012.03.023$$o10.1016/j.neuron.2012.03.023
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.2801$$o10.1038/nn.2801
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1136/bmj.e6231$$o10.1136/bmj.e6231
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1136/bmj.g5205$$o10.1136/bmj.g5205
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0140-6736(06)69113-7$$o10.1016/S0140-6736(06)69113-7
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1056/NEJM200008173430701$$o10.1056/NEJM200008173430701
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-013-1242-2$$o10.1007/s00401-013-1242-2
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2177-05.2005$$o10.1523/JNEUROSCI.2177-05.2005
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1206171109$$o10.1073/pnas.1206171109
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1162844$$o10.1126/science.1162844
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0802908105$$o10.1073/pnas.0802908105
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2005.10.028$$o10.1016/j.neuron.2005.10.028
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M113.491001$$o10.1074/jbc.M113.491001
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.4161/auto.19048$$o10.4161/auto.19048
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.yebeh.2003.07.008$$o10.1016/j.yebeh.2003.07.008
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0811879106$$o10.1073/pnas.0811879106
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.celrep.2014.04.024$$o10.1016/j.celrep.2014.04.024
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms1783$$o10.1038/ncomms1783
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/359322a0$$o10.1038/359322a0
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1566067$$o10.1126/science.1566067
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1528-1167.2012.03603.x$$o10.1111/j.1528-1167.2012.03603.x
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2010.11.030$$o10.1016/j.neuron.2010.11.030
000138871 999C5 $$2Crossref$$oInternational AsD World Alzheimer Report 2015$$tWorld Alzheimer Report$$y2015
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2010.06.036$$o10.1016/j.cell.2010.06.036
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/jama.2015.4668$$o10.1001/jama.2015.4668
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(03)00124-7$$o10.1016/S0896-6273(03)00124-7
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2009.06.026$$o10.1016/j.neuron.2009.06.026
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0811698106$$o10.1073/pnas.0811698106
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropharm.2012.06.023$$o10.1016/j.neuropharm.2012.06.023
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2008.06.008$$o10.1016/j.neuron.2008.06.008
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1169096$$o10.1126/science.1169096
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.euroneuro.2011.02.001$$o10.1016/j.euroneuro.2011.02.001
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature09108$$o10.1038/nature09108
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0053569$$o10.1371/journal.pone.0053569
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2009.05.012$$o10.1016/j.neuron.2009.05.012
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.15252/emmm.201505026$$o10.15252/emmm.201505026
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nm.3734$$o10.1038/nm.3734
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2015.01.025$$o10.1016/j.neuron.2015.01.025
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2011.04.009$$o10.1016/j.neuron.2011.04.009
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0b013e3181e3966e$$o10.1212/WNL.0b013e3181e3966e
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1750-1326-5-45$$o10.1186/1750-1326-5-45
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2007.07.025$$o10.1016/j.neuron.2007.07.025
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ana.22105$$o10.1002/ana.22105
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4152-10.2011$$o10.1523/JNEUROSCI.4152-10.2011
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1141736$$o10.1126/science.1141736
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3199$$o10.1038/nn.3199
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1121081109$$o10.1073/pnas.1121081109
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2010.12.012$$o10.1016/j.neurobiolaging.2010.12.012
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1074069$$o10.1126/science.1074069
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0197-4580(00)00229-3$$o10.1016/S0197-4580(00)00229-3
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2009.07.003$$o10.1016/j.neuron.2009.07.003
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neulet.2014.01.013$$o10.1016/j.neulet.2014.01.013
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1232232100$$o10.1073/pnas.1232232100
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.0950-15.2015$$o10.1523/JNEUROSCI.0950-15.2015
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2012.02.046$$o10.1016/j.cell.2012.02.046
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/jamaneurol.2013.136$$o10.1001/jamaneurol.2013.136
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1128134$$o10.1126/science.1128134
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature14864$$o10.1038/nature14864
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1744-05.2005$$o10.1523/JNEUROSCI.1744-05.2005
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3233/JAD-142874$$o10.3233/JAD-142874
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2014.12.064$$o10.1016/j.neuron.2014.12.064
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.celrep.2015.04.017$$o10.1016/j.celrep.2015.04.017
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2013.07.046$$o10.1016/j.neuron.2013.07.046
000138871 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2014.08.004$$o10.1016/j.tins.2014.08.004