TY  - JOUR
AU  - Baykara, Ebru
AU  - Gesierich, Benno
AU  - Adam, Ruth
AU  - Tuladhar, Anil Man
AU  - Biesbroek, J Matthijs
AU  - Koek, Huiberdina L
AU  - Ropele, Stefan
AU  - Jouvent, Eric
AU  - Initiative, Alzheimer's Disease Neuroimaging
AU  - Chabriat, Hugues
AU  - Ertl-Wagner, Birgit
AU  - Ewers, Michael
AU  - Schmidt, Reinhold
AU  - de Leeuw, Frank-Erik
AU  - Biessels, Geert Jan
AU  - Dichgans, Martin
AU  - Duering, Marco
TI  - A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms.
JO  - Annals of neurology
VL  - 80
IS  - 4
SN  - 0364-5134
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DZNE-2020-05212
SP  - 581-592
PY  - 2016
AB  - To establish a fully automated, robust imaging marker for cerebral small vessel disease (SVD) and related cognitive impairment that is easy to implement, reflects disease burden, and is strongly associated with processing speed, the predominantly affected cognitive domain in SVD.We developed a novel magnetic resonance imaging marker based on diffusion tensor imaging, skeletonization of white matter tracts, and histogram analysis. The marker (peak width of skeletonized mean diffusivity [PSMD]) was assessed along with conventional SVD imaging markers. We first evaluated associations with processing speed in patients with genetically defined SVD (n = 113). Next, we validated our findings in independent samples of inherited SVD (n = 57), sporadic SVD (n = 444), and memory clinic patients with SVD (n = 105). The new marker was further applied to healthy controls (n = 241) and to patients with Alzheimer's disease (n = 153). We further conducted a longitudinal analysis and interscanner reproducibility study.PSMD was associated with processing speed in all study samples with SVD (p-values between 2.8 × 10(-3) and 1.8 × 10(-10) ). PSMD explained most of the variance in processing speed (R(2) ranging from 8.8
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: diagnostic imaging
KW  - Biomarkers
KW  - Cerebral Small Vessel Diseases: complications
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: physiopathology
KW  - Diffusion Tensor Imaging: methods
KW  - Diffusion Tensor Imaging: standards
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Reproducibility of Results
KW  - White Matter: diagnostic imaging
KW  - Young Adult
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27518166
DO  - DOI:10.1002/ana.24758
UR  - https://pub.dzne.de/record/138890
ER  -