%0 Journal Article
%A Liu, Ganqiang
%A Boot, Brendon
%A Locascio, Joseph J
%A Jansen, Iris E
%A Winder-Rhodes, Sophie
%A Eberly, Shirley
%A Elbaz, Alexis
%A Brice, Alexis
%A Ravina, Bernard
%A van Hilten, Jacobus J
%A Cormier-Dequaire, Florence
%A Corvol, Jean-Christophe
%A Barker, Roger A
%A Heutink, Peter
%A Marinus, Johan
%A Williams-Gray, Caroline H
%A Scherzer, Clemens R
%A Progression, International Genetics of Parkinson Disease
%A Scherzer, C.
%A Hyman, B. T.
%A Ivinson, A. J.
%A Trisini-Lipsanopoulos, A.
%A Franco, D.
%A Burke, K.
%A Sudarsky, L. R.
%A Hayes, M. T.
%A Umeh, C. C.
%A Growdon, J. H.
%A Schwarzschild, M. A.
%A Hung, A. Y.
%A Flaherty, A. W.
%A Wills, A-M
%A Mejia, N. I.
%A Gomperts, S. N.
%A Khurana, V.
%A Selkoe, D. J.
%A Yi, T.
%A Page, K.
%A Liao, Z.
%A Barker, R.
%A Foltynie, T.
%A Williams-Gray, C. H.
%A Mason, S.
%A Winder-Rhodes, S.
%A Barker, R.
%A Williams-Gray, C. H.
%A Breen, D.
%A Cummins, G.
%A Evans, J.
%A Winder-Rhodes, S.
%A Corvol, J-C
%A Brice, A.
%A Elbaz, A.
%A Mallet, A.
%A Vidailhet, M.
%A Bonnet, A-M
%A Bonnet, C.
%A Grabli, D.
%A Hartmann, A.
%A Klebe, S.
%A Lacomblez, L.
%A Mangone, G.
%A Bourdain, F.
%A Brandel, J-P
%A Derkinderen, P.
%A Durif, F.
%A Mesnage, V.
%A Pico, F.
%A Rascol, O.
%A Forlani, S.
%A Lesage, S.
%A Tahiri, K.
%A van Hilten, J. J.
%A Marinus, J.
%A Liao, Z.
%A Page, K.
%A Franco, D.
%A Duong, K.
%A Yi, T.
%A Trisini-Lipsanopoulos, A.
%A Dong, X.
%A Sudarsky, L. R.
%A Hutten, S. J.
%A Amr, S. S.
%A Shoulson, I.
%A Tanner, C. M.
%A Lang, A. E.
%A Nalls, M. A.
%T Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
%J Annals of neurology
%V 80
%N 5
%@ 0364-5134
%C Hoboken, NJ
%I Wiley-Blackwell
%M DZNE-2020-05214
%P 674-685
%D 2016
%X We hypothesized that specific mutations in the β-glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease (PD) patients, whereas non-neuropathic GD mutations confer intermediate progression rates.A total of 2,304 patients with PD and 20,868 longitudinal visits for up to 12.8 years (median, 4.1) from seven cohorts were analyzed. Differential effects of four types of genetic variation in GBA on longitudinal cognitive decline were evaluated using mixed random and fixed effects and Cox proportional hazards models.Overall, 10.3
%K Aged
%K Aged, 80 and over
%K Cognitive Dysfunction: etiology
%K Cognitive Dysfunction: genetics
%K Disease Progression
%K Female
%K Gaucher Disease: complications
%K Gaucher Disease: genetics
%K Glucosylceramidase: genetics
%K Humans
%K Longitudinal Studies
%K Male
%K Middle Aged
%K Parkinson Disease: complications
%K Parkinson Disease: genetics
%K Glucosylceramidase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27717005
%2 pmc:PMC5244667
%R 10.1002/ana.24781
%U https://pub.dzne.de/record/138892