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000138902 0247_ $$2doi$$a10.1038/cdd.2016.79
000138902 0247_ $$2pmid$$apmid:27518434
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000138902 037__ $$aDZNE-2020-05224
000138902 041__ $$aEnglish
000138902 082__ $$a610
000138902 1001_ $$0P:(DE-2719)2810874$$aKörver, Lisa$$b0$$eFirst author$$udzne
000138902 245__ $$aThe de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila.
000138902 260__ $$aLondon$$bMacmillan$$c2016
000138902 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2016-08-12
000138902 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2016-12-01
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000138902 520__ $$aDe-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase ubiquitylation to regulate cell survival, we identified the Drosophila ovarian tumour-type DUB DUBA (CG6091). DUBA physically interacts with the initiator caspase death regulator Nedd2-like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye. Searching also for non-apoptotic functions of DUBA, we found that Duba-null mutants are male sterile and display defects in spermatid individualisation, a process that depends on non-apoptotic caspase activity. Spermatids of DUBA-deficient flies showed reduced caspase activity and lack critical structures of the individualisation process. Biochemical characterisation revealed an obligate activation step of DUBA by phosphorylation. With genetic rescue experiments we demonstrate that DUBA phosphorylation and catalytic activity are crucial in vivo for DUBA function in spermatogenesis. Our results demonstrate for the first time the importance of de-ubiquitylation for fly spermatogenesis.
000138902 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000138902 542__ $$2Crossref$$i2016-08-12$$uhttp://www.springer.com/tdm
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000138902 650_7 $$2NLM Chemicals$$aDrosophila Proteins
000138902 650_7 $$2NLM Chemicals$$aUbiquitinated Proteins
000138902 650_7 $$017885-08-4$$2NLM Chemicals$$aPhosphoserine
000138902 650_7 $$0EC 3.4.19.12$$2NLM Chemicals$$aDUBA protein, Drosophila
000138902 650_7 $$0EC 3.4.19.12$$2NLM Chemicals$$aDeubiquitinating Enzymes
000138902 650_7 $$0EC 3.4.22.-$$2NLM Chemicals$$aCaspases
000138902 650_2 $$2MeSH$$aAmino Acid Sequence
000138902 650_2 $$2MeSH$$aAnimals
000138902 650_2 $$2MeSH$$aApoptosis
000138902 650_2 $$2MeSH$$aBiocatalysis
000138902 650_2 $$2MeSH$$aCaspases: metabolism
000138902 650_2 $$2MeSH$$aDeubiquitinating Enzymes: chemistry
000138902 650_2 $$2MeSH$$aDeubiquitinating Enzymes: metabolism
000138902 650_2 $$2MeSH$$aDrosophila Proteins: chemistry
000138902 650_2 $$2MeSH$$aDrosophila Proteins: metabolism
000138902 650_2 $$2MeSH$$aDrosophila melanogaster: enzymology
000138902 650_2 $$2MeSH$$aDrosophila melanogaster: physiology
000138902 650_2 $$2MeSH$$aMale
000138902 650_2 $$2MeSH$$aPhosphorylation
000138902 650_2 $$2MeSH$$aPhosphoserine: metabolism
000138902 650_2 $$2MeSH$$aProtein Binding
000138902 650_2 $$2MeSH$$aSpermatogenesis
000138902 650_2 $$2MeSH$$aTestis: metabolism
000138902 650_2 $$2MeSH$$aUbiquitinated Proteins: metabolism
000138902 650_2 $$2MeSH$$aUbiquitination
000138902 7001_ $$0P:(DE-2719)2810805$$aMelzer, Juliane$$b1$$udzne
000138902 7001_ $$0P:(DE-2719)2810320$$aAguado Roca, Eva$$b2$$udzne
000138902 7001_ $$0P:(DE-2719)2810393$$aTeichert, Dominic$$b3$$udzne
000138902 7001_ $$0P:(DE-HGF)0$$aGlatter, Timo$$b4
000138902 7001_ $$0P:(DE-HGF)0$$aArama, Eli$$b5
000138902 7001_ $$0P:(DE-2719)2810307$$aBroemer, Meike$$b6$$eLast author$$udzne
000138902 77318 $$2Crossref$$3journal-article$$a10.1038/cdd.2016.79$$b : Springer Science and Business Media LLC, 2016-08-12$$n12$$p2019-2030$$tCell Death & Differentiation$$v23$$x1350-9047$$y2016
000138902 773__ $$0PERI:(DE-600)1496681-5$$a10.1038/cdd.2016.79$$gVol. 23, no. 12, p. 2019 - 2030$$n12$$p2019-2030$$q23:12<2019 - 2030$$tCell death and differentiation$$v23$$x1350-9047$$y2016
000138902 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136489
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000138902 999C5 $$2Crossref$$oMH Bre 1996$$y1996
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000138902 999C5 $$2Crossref$$oL Yue 1999$$y1999
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000138902 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/dev.098947$$o10.1242/dev.098947
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000138902 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb1204$$o10.1038/ncb1204
000138902 999C5 $$2Crossref$$oI Schneider 1972$$y1972