guest ::
| Home > Publications Database > Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. > print |
| Home > Publications Database > Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. > print |
| 001 | 138990 | ||
| 005 | 20240524120326.0 | ||
| 024 | 7 | _ | |a 10.1194/jlr.M068676 |2 doi |
| 024 | 7 | _ | |a pmid:27881717 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5234710 |2 pmc |
| 024 | 7 | _ | |a 0022-2275 |2 ISSN |
| 024 | 7 | _ | |a 1539-7262 |2 ISSN |
| 024 | 7 | _ | |a altmetric:15391718 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05312 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Alecu, Irina |b 0 |
| 245 | _ | _ | |a Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. |
| 260 | _ | _ | |a Bethesda, Md. |c 2017 |b ASBMB |
| 264 | _ | 1 | |3 online |2 Crossref |b American Society for Biochemistry & Molecular Biology (ASBMB) |c 2016-11-23 |
| 264 | _ | 1 | |3 print |2 Crossref |b American Society for Biochemistry & Molecular Biology (ASBMB) |c 2017-01-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1716472934_3149 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a 1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and HSAN1 are very similar, suggesting the involvement of deoxySLs in the pathology of both diseases. However, very little is known about the biology of these lipids and the underlying pathomechanism. We synthesized an alkyne analog of 1-deoxysphinganine (doxSA), the metabolic precursor of all deoxySLs, to trace the metabolism and localization of deoxySLs. Our results indicate that the metabolism of these lipids is restricted to only some lipid species and that they are not converted to canonical sphingolipids or fatty acids. Furthermore, exogenously added alkyne-doxSA [(2S,3R)-2-aminooctadec-17-yn-3-ol] localized to mitochondria, causing mitochondrial fragmentation and dysfunction. The induced mitochondrial toxicity was also shown for natural doxSA, but not for sphinganine, and was rescued by inhibition of ceramide synthase activity. Our findings therefore indicate that mitochondrial enrichment of an N-acylated doxSA metabolite may contribute to the neurotoxicity seen in diabetic neuropathy and HSAN1. Hence, we provide a potential explanation for the characteristic vulnerability of peripheral nerves to elevated levels of deoxySLs. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Lipids |2 NLM Chemicals |
| 650 | _ | 7 | |a Sphingolipids |2 NLM Chemicals |
| 650 | _ | 7 | |a Oxidoreductases |0 EC 1.- |2 NLM Chemicals |
| 650 | _ | 7 | |a dihydroceramide desaturase |0 EC 1.3.1.- |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Diabetes Mellitus, Type 2: blood |2 MeSH |
| 650 | _ | 2 | |a Diabetes Mellitus, Type 2: pathology |2 MeSH |
| 650 | _ | 2 | |a Diabetic Neuropathies: blood |2 MeSH |
| 650 | _ | 2 | |a Diabetic Neuropathies: pathology |2 MeSH |
| 650 | _ | 2 | |a Hereditary Sensory and Autonomic Neuropathies: blood |2 MeSH |
| 650 | _ | 2 | |a Hereditary Sensory and Autonomic Neuropathies: pathology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Lipids: blood |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: drug effects |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: pathology |2 MeSH |
| 650 | _ | 2 | |a Oxidoreductases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Peripheral Nerves: metabolism |2 MeSH |
| 650 | _ | 2 | |a Peripheral Nerves: pathology |2 MeSH |
| 650 | _ | 2 | |a Sphingolipids: blood |2 MeSH |
| 650 | _ | 2 | |a Sphingolipids: chemical synthesis |2 MeSH |
| 650 | _ | 2 | |a Sphingolipids: pharmacology |2 MeSH |
| 700 | 1 | _ | |a Tedeschi, Andrea |0 P:(DE-2719)2810470 |b 1 |u dzne |
| 700 | 1 | _ | |a Behler, Natascha |b 2 |
| 700 | 1 | _ | |a Wunderling, Klaus |b 3 |
| 700 | 1 | _ | |a Lamberz, Christian |0 P:(DE-2719)2811203 |b 4 |u dzne |
| 700 | 1 | _ | |a Lauterbach, Mario A R |b 5 |
| 700 | 1 | _ | |a Gaebler, Anne |b 6 |
| 700 | 1 | _ | |a Ernst, Daniela |b 7 |
| 700 | 1 | _ | |a Van Veldhoven, Paul P |b 8 |
| 700 | 1 | _ | |a Alamoudi, Ashraf |0 P:(DE-2719)2259138 |b 9 |u dzne |
| 700 | 1 | _ | |a Latz, Eicke |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Othman, Alaa |b 11 |
| 700 | 1 | _ | |a Kuerschner, Lars |b 12 |
| 700 | 1 | _ | |a Hornemann, Thorsten |b 13 |
| 700 | 1 | _ | |a Bradke, Frank |0 P:(DE-2719)2810270 |b 14 |u dzne |
| 700 | 1 | _ | |a Thiele, Christoph |b 15 |
| 700 | 1 | _ | |a Penno, Anke |0 P:(DE-HGF)0 |b 16 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1194/jlr.m068676 |b : American Society for Biochemistry & Molecular Biology (ASBMB), 2016-11-23 |n 1 |p 42-59 |3 journal-article |2 Crossref |t Journal of Lipid Research |v 58 |y 2016 |x 0022-2275 |
| 773 | _ | _ | |a 10.1194/jlr.M068676 |g Vol. 58, no. 1, p. 42 - 59 |0 PERI:(DE-600)1466675-3 |n 1 |q 58:1<42 - 59 |p 42-59 |t Journal of lipid research |v 58 |y 2017 |x 0022-2275 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/138990/files/DZNE-2020-05312.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/138990/files/DZNE-2020-05312.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234710 |
| 909 | C | O | |o oai:pub.dzne.de:138990 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2810470 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)2811203 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 9 |6 P:(DE-2719)2259138 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 14 |6 P:(DE-2719)2810270 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Molecular Signaling |x 0 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-18 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J LIPID RES : 2021 |d 2022-11-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2022-08-11T09:56:38Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2022-08-11T09:56:38Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-18 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Blind peer review |d 2022-08-11T09:56:38Z |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b J LIPID RES : 2021 |d 2022-11-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-18 |
| 920 | 1 | _ | |0 I:(DE-2719)1013002 |k AG Bradke |l Axon Growth and Regeneration |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013012 |k AG Alamoudi |l Cryo-electron microscopy and tomography |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1013002 |
| 980 | _ | _ | |a I:(DE-2719)1013012 |
| 980 | 1 | _ | |a FullTexts |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M808798200 |2 Crossref |o 10.1074/jbc.M808798200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M109.092973 |2 Crossref |o 10.1074/jbc.M109.092973 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/awh712 |2 Crossref |o 10.1093/brain/awh712 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/85817 |2 Crossref |o 10.1038/85817 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/85879 |2 Crossref |o 10.1038/85879 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ejmg.2013.02.002 |2 Crossref |o 10.1016/j.ejmg.2013.02.002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/humu.21481 |2 Crossref |o 10.1002/humu.21481 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.0b013e318295d789 |2 Crossref |o 10.1212/WNL.0b013e318295d789 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s12017-014-8339-1 |2 Crossref |o 10.1007/s12017-014-8339-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/ddv611 |2 Crossref |o 10.1093/hmg/ddv611 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0960-8966(12)70050-0 |2 Crossref |o 10.1016/S0960-8966(12)70050-0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2536-09.2009 |2 Crossref |o 10.1523/JNEUROSCI.2536-09.2009 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1172/JCI57549 |2 Crossref |o 10.1172/JCI57549 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/ddv390 |2 Crossref |o 10.1093/hmg/ddv390 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00125-011-2384-1 |2 Crossref |o 10.1007/s00125-011-2384-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1186/1476-511X-9-84 |2 Crossref |o 10.1186/1476-511X-9-84 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1136/bmjdrc-2014-000073 |2 Crossref |o 10.1136/bmjdrc-2014-000073 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2337/db14-1325 |2 Crossref |o 10.2337/db14-1325 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.273.30.19060 |2 Crossref |o 10.1074/jbc.273.30.19060 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1021/jo400440z |2 Crossref |o 10.1021/jo400440z |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M114.603860 |2 Crossref |o 10.1074/jbc.M114.603860 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1194/jlr.P056002 |2 Crossref |o 10.1194/jlr.P056002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1096/fj.15-272567 |2 Crossref |o 10.1096/fj.15-272567 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1194/jlr.M067033 |2 Crossref |o 10.1194/jlr.M067033 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.molcel.2012.04.033 |2 Crossref |o 10.1016/j.molcel.2012.04.033 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.113.6.1267 |2 Crossref |o 10.1083/jcb.113.6.1267 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1194/jlr.D038653 |2 Crossref |o 10.1194/jlr.D038653 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1021/cb300414v |2 Crossref |o 10.1021/cb300414v |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1194/jlr.D044727 |2 Crossref |o 10.1194/jlr.D044727 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cellsig.2009.11.001 |2 Crossref |o 10.1016/j.cellsig.2009.11.001 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/1522-7189(199911/12)7:6<407::AID-NT84>3.0.CO;2-0 |2 Crossref |o 10.1002/1522-7189(199911/12)7:6<407::AID-NT84>3.0.CO;2-0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nmeth.2019 |2 Crossref |o 10.1038/nmeth.2019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni907 |2 Crossref |o 10.1038/ni907 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5 |2 Crossref |o 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.bbalip.2014.01.003 |2 Crossref |o 10.1016/j.bbalip.2014.01.003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.bbalip.2013.12.018 |2 Crossref |o 10.1016/j.bbalip.2013.12.018 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1194/jlr.D070565 |2 Crossref |o 10.1194/jlr.D070565 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0907864106 |2 Crossref |o 10.1073/pnas.0907864106 |
| 999 | C | 5 | |2 Crossref |o |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1158/1535-7163.MCT-08-1167 |2 Crossref |o 10.1158/1535-7163.MCT-08-1167 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00280-011-1612-1 |2 Crossref |o 10.1007/s00280-011-1612-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10637-010-9529-9 |2 Crossref |o 10.1007/s10637-010-9529-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10637-011-9772-8 |2 Crossref |o 10.1007/s10637-011-9772-8 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M110.214866 |2 Crossref |o 10.1074/jbc.M110.214866 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1089/ars.2007.1800 |2 Crossref |o 10.1089/ars.2007.1800 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ceb.2014.03.005 |2 Crossref |o 10.1016/j.ceb.2014.03.005 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2144/000113610 |2 Crossref |o 10.2144/000113610 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cub.2010.05.055 |2 Crossref |o 10.1016/j.cub.2010.05.055 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.R115.658823 |2 Crossref |o 10.1074/jbc.R115.658823 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1155/2008/420747 |2 Crossref |o 10.1155/2008/420747 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10495-006-0573-z |2 Crossref |o 10.1007/s10495-006-0573-z |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1089/dna.2013.2182 |2 Crossref |o 10.1089/dna.2013.2182 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuropharm.2016.03.033 |2 Crossref |o 10.1016/j.neuropharm.2016.03.033 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrneurol.2014.77 |2 Crossref |o 10.1038/nrneurol.2014.77 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neulet.2015.04.001 |2 Crossref |o 10.1016/j.neulet.2015.04.001 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00439-004-1199-2 |2 Crossref |o 10.1007/s00439-004-1199-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.4798-06.2007 |2 Crossref |o 10.1523/JNEUROSCI.4798-06.2007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuroscience.2011.12.023 |2 Crossref |o 10.1016/j.neuroscience.2011.12.023 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|