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000139027 0247_ $$2doi$$a10.1002/glia.23088
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000139027 037__ $$aDZNE-2020-05349
000139027 041__ $$aEnglish
000139027 082__ $$a610
000139027 1001_ $$0P:(DE-HGF)0$$aHofmann, Kristina$$b0
000139027 245__ $$aTanycytes and a differential fatty acid metabolism in the hypothalamus.
000139027 260__ $$aBognor Regis [u.a.]$$bWiley-Liss$$c2017
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000139027 520__ $$aAlthough the brain controls all main metabolic pathways in the whole organism, its lipid metabolism is partially separated from the rest of the body. Circulating lipids and other metabolites are taken up into brain areas like the hypothalamus and are locally metabolized and sensed involving several hypothalamic cell types. In this study we show that saturated and unsaturated fatty acids are differentially processed in the murine hypothalamus. The observed differences involve both lipid distribution and metabolism. Key findings were: (i) hypothalamic astrocytes are targeted by unsaturated, but not saturated lipids in lean mice; (ii) in obese mice labeling of these astrocytes by unsaturated oleic acid cannot be detected unless β-oxidation or ketogenesis is inhibited; (iii) the hypothalamus of obese animals increases ketone body and neutral lipid synthesis while tanycytes, hypothalamic cells facing the ventricle, increase their lipid droplet content; and (iv) tanycytes show different labeling for saturated or unsaturated lipids. Our data support a metabolic connection between tanycytes and astrocytes likely to impact hypothalamic lipid sensing. GLIA 2017;65:231-249.
000139027 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
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000139027 650_7 $$2NLM Chemicals$$aExcitatory Amino Acid Transporter 1
000139027 650_7 $$2NLM Chemicals$$aFatty Acids
000139027 650_7 $$2NLM Chemicals$$aGlial Fibrillary Acidic Protein
000139027 650_7 $$2NLM Chemicals$$aKetone Bodies
000139027 650_7 $$2NLM Chemicals$$aLuminescent Proteins
000139027 650_7 $$2NLM Chemicals$$aOligodendrocyte Transcription Factor 2
000139027 650_7 $$2NLM Chemicals$$aSlc1a3 protein, mouse
000139027 650_2 $$2MeSH$$aAnimals
000139027 650_2 $$2MeSH$$aAstrocytes: metabolism
000139027 650_2 $$2MeSH$$aDiet, High-Fat: adverse effects
000139027 650_2 $$2MeSH$$aDisease Models, Animal
000139027 650_2 $$2MeSH$$aEpendymoglial Cells: metabolism
000139027 650_2 $$2MeSH$$aEpendymoglial Cells: ultrastructure
000139027 650_2 $$2MeSH$$aExcitatory Amino Acid Transporter 1: genetics
000139027 650_2 $$2MeSH$$aExcitatory Amino Acid Transporter 1: metabolism
000139027 650_2 $$2MeSH$$aFatty Acids: metabolism
000139027 650_2 $$2MeSH$$aGlial Fibrillary Acidic Protein: genetics
000139027 650_2 $$2MeSH$$aGlial Fibrillary Acidic Protein: metabolism
000139027 650_2 $$2MeSH$$aHypothalamus: cytology
000139027 650_2 $$2MeSH$$aHypothalamus: metabolism
000139027 650_2 $$2MeSH$$aIn Vitro Techniques
000139027 650_2 $$2MeSH$$aKetone Bodies: metabolism
000139027 650_2 $$2MeSH$$aLipid Metabolism: physiology
000139027 650_2 $$2MeSH$$aLuminescent Proteins: genetics
000139027 650_2 $$2MeSH$$aLuminescent Proteins: metabolism
000139027 650_2 $$2MeSH$$aMale
000139027 650_2 $$2MeSH$$aMice
000139027 650_2 $$2MeSH$$aMice, Inbred C57BL
000139027 650_2 $$2MeSH$$aMice, Transgenic
000139027 650_2 $$2MeSH$$aObesity: chemically induced
000139027 650_2 $$2MeSH$$aObesity: pathology
000139027 650_2 $$2MeSH$$aOligodendrocyte Transcription Factor 2: metabolism
000139027 650_2 $$2MeSH$$aOrgan Culture Techniques
000139027 7001_ $$0P:(DE-2719)2811203$$aLamberz, Christian$$b1$$udzne
000139027 7001_ $$0P:(DE-HGF)0$$aPiotrowitz, Kira$$b2
000139027 7001_ $$0P:(DE-HGF)0$$aOffermann, Nina$$b3
000139027 7001_ $$0P:(DE-HGF)0$$aBut, Diana$$b4
000139027 7001_ $$0P:(DE-HGF)0$$aScheller, Anja$$b5
000139027 7001_ $$0P:(DE-2719)2259138$$aAlamoudi, Ashraf$$b6$$udzne
000139027 7001_ $$0P:(DE-HGF)0$$aKuerschner, Lars$$b7$$eCorresponding author
000139027 77318 $$2Crossref$$3journal-article$$a10.1002/glia.23088$$b : Wiley, 2016-10-11$$n2$$p231-249$$tGlia$$v65$$x0894-1491$$y2016
000139027 773__ $$0PERI:(DE-600)1474828-9$$a10.1002/glia.23088$$gVol. 65, no. 2, p. 231 - 249$$n2$$p231-249$$q65:2<231 - 249$$tGlia$$v65$$x0894-1491$$y2016
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000139027 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811203$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
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000139027 9131_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000139027 9141_ $$y2017
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