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@ARTICLE{Hofmann:139027,
      author       = {Hofmann, Kristina and Lamberz, Christian and Piotrowitz,
                      Kira and Offermann, Nina and But, Diana and Scheller, Anja
                      and Alamoudi, Ashraf and Kuerschner, Lars},
      title        = {{T}anycytes and a differential fatty acid metabolism in the
                      hypothalamus.},
      journal      = {Glia},
      volume       = {65},
      number       = {2},
      issn         = {0894-1491},
      address      = {Bognor Regis [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2020-05349},
      pages        = {231-249},
      year         = {2017},
      abstract     = {Although the brain controls all main metabolic pathways in
                      the whole organism, its lipid metabolism is partially
                      separated from the rest of the body. Circulating lipids and
                      other metabolites are taken up into brain areas like the
                      hypothalamus and are locally metabolized and sensed
                      involving several hypothalamic cell types. In this study we
                      show that saturated and unsaturated fatty acids are
                      differentially processed in the murine hypothalamus. The
                      observed differences involve both lipid distribution and
                      metabolism. Key findings were: (i) hypothalamic astrocytes
                      are targeted by unsaturated, but not saturated lipids in
                      lean mice; (ii) in obese mice labeling of these astrocytes
                      by unsaturated oleic acid cannot be detected unless
                      β-oxidation or ketogenesis is inhibited; (iii) the
                      hypothalamus of obese animals increases ketone body and
                      neutral lipid synthesis while tanycytes, hypothalamic cells
                      facing the ventricle, increase their lipid droplet content;
                      and (iv) tanycytes show different labeling for saturated or
                      unsaturated lipids. Our data support a metabolic connection
                      between tanycytes and astrocytes likely to impact
                      hypothalamic lipid sensing. GLIA 2017;65:231-249.},
      keywords     = {Animals / Astrocytes: metabolism / Diet, High-Fat: adverse
                      effects / Disease Models, Animal / Ependymoglial Cells:
                      metabolism / Ependymoglial Cells: ultrastructure /
                      Excitatory Amino Acid Transporter 1: genetics / Excitatory
                      Amino Acid Transporter 1: metabolism / Fatty Acids:
                      metabolism / Glial Fibrillary Acidic Protein: genetics /
                      Glial Fibrillary Acidic Protein: metabolism / Hypothalamus:
                      cytology / Hypothalamus: metabolism / In Vitro Techniques /
                      Ketone Bodies: metabolism / Lipid Metabolism: physiology /
                      Luminescent Proteins: genetics / Luminescent Proteins:
                      metabolism / Male / Mice / Mice, Inbred C57BL / Mice,
                      Transgenic / Obesity: chemically induced / Obesity:
                      pathology / Oligodendrocyte Transcription Factor 2:
                      metabolism / Organ Culture Techniques / Excitatory Amino
                      Acid Transporter 1 (NLM Chemicals) / Fatty Acids (NLM
                      Chemicals) / Glial Fibrillary Acidic Protein (NLM Chemicals)
                      / Ketone Bodies (NLM Chemicals) / Luminescent Proteins (NLM
                      Chemicals) / Oligodendrocyte Transcription Factor 2 (NLM
                      Chemicals) / Slc1a3 protein, mouse (NLM Chemicals)},
      cin          = {AG Alamoudi},
      ddc          = {610},
      cid          = {I:(DE-2719)1013012},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27726181},
      doi          = {10.1002/glia.23088},
      url          = {https://pub.dzne.de/record/139027},
}