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| 001 | 139027 | ||
| 005 | 20240321220536.0 | ||
| 024 | 7 | _ | |a 10.1002/glia.23088 |2 doi |
| 024 | 7 | _ | |a pmid:27726181 |2 pmid |
| 024 | 7 | _ | |a 0894-1491 |2 ISSN |
| 024 | 7 | _ | |a 1098-1136 |2 ISSN |
| 024 | 7 | _ | |a altmetric:12558689 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05349 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Hofmann, Kristina |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Tanycytes and a differential fatty acid metabolism in the hypothalamus. |
| 260 | _ | _ | |a Bognor Regis [u.a.] |c 2017 |b Wiley-Liss |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2016-10-11 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2017-02-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1587466018_3651 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Although the brain controls all main metabolic pathways in the whole organism, its lipid metabolism is partially separated from the rest of the body. Circulating lipids and other metabolites are taken up into brain areas like the hypothalamus and are locally metabolized and sensed involving several hypothalamic cell types. In this study we show that saturated and unsaturated fatty acids are differentially processed in the murine hypothalamus. The observed differences involve both lipid distribution and metabolism. Key findings were: (i) hypothalamic astrocytes are targeted by unsaturated, but not saturated lipids in lean mice; (ii) in obese mice labeling of these astrocytes by unsaturated oleic acid cannot be detected unless β-oxidation or ketogenesis is inhibited; (iii) the hypothalamus of obese animals increases ketone body and neutral lipid synthesis while tanycytes, hypothalamic cells facing the ventricle, increase their lipid droplet content; and (iv) tanycytes show different labeling for saturated or unsaturated lipids. Our data support a metabolic connection between tanycytes and astrocytes likely to impact hypothalamic lipid sensing. GLIA 2017;65:231-249. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2016-10-11 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1 |
| 542 | _ | _ | |i 2016-10-11 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Excitatory Amino Acid Transporter 1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Fatty Acids |2 NLM Chemicals |
| 650 | _ | 7 | |a Glial Fibrillary Acidic Protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Ketone Bodies |2 NLM Chemicals |
| 650 | _ | 7 | |a Luminescent Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Oligodendrocyte Transcription Factor 2 |2 NLM Chemicals |
| 650 | _ | 7 | |a Slc1a3 protein, mouse |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: metabolism |2 MeSH |
| 650 | _ | 2 | |a Diet, High-Fat: adverse effects |2 MeSH |
| 650 | _ | 2 | |a Disease Models, Animal |2 MeSH |
| 650 | _ | 2 | |a Ependymoglial Cells: metabolism |2 MeSH |
| 650 | _ | 2 | |a Ependymoglial Cells: ultrastructure |2 MeSH |
| 650 | _ | 2 | |a Excitatory Amino Acid Transporter 1: genetics |2 MeSH |
| 650 | _ | 2 | |a Excitatory Amino Acid Transporter 1: metabolism |2 MeSH |
| 650 | _ | 2 | |a Fatty Acids: metabolism |2 MeSH |
| 650 | _ | 2 | |a Glial Fibrillary Acidic Protein: genetics |2 MeSH |
| 650 | _ | 2 | |a Glial Fibrillary Acidic Protein: metabolism |2 MeSH |
| 650 | _ | 2 | |a Hypothalamus: cytology |2 MeSH |
| 650 | _ | 2 | |a Hypothalamus: metabolism |2 MeSH |
| 650 | _ | 2 | |a In Vitro Techniques |2 MeSH |
| 650 | _ | 2 | |a Ketone Bodies: metabolism |2 MeSH |
| 650 | _ | 2 | |a Lipid Metabolism: physiology |2 MeSH |
| 650 | _ | 2 | |a Luminescent Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Luminescent Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Transgenic |2 MeSH |
| 650 | _ | 2 | |a Obesity: chemically induced |2 MeSH |
| 650 | _ | 2 | |a Obesity: pathology |2 MeSH |
| 650 | _ | 2 | |a Oligodendrocyte Transcription Factor 2: metabolism |2 MeSH |
| 650 | _ | 2 | |a Organ Culture Techniques |2 MeSH |
| 700 | 1 | _ | |a Lamberz, Christian |0 P:(DE-2719)2811203 |b 1 |u dzne |
| 700 | 1 | _ | |a Piotrowitz, Kira |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Offermann, Nina |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a But, Diana |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Scheller, Anja |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Alamoudi, Ashraf |0 P:(DE-2719)2259138 |b 6 |u dzne |
| 700 | 1 | _ | |a Kuerschner, Lars |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1002/glia.23088 |b : Wiley, 2016-10-11 |n 2 |p 231-249 |3 journal-article |2 Crossref |t Glia |v 65 |y 2016 |x 0894-1491 |
| 773 | _ | _ | |a 10.1002/glia.23088 |g Vol. 65, no. 2, p. 231 - 249 |0 PERI:(DE-600)1474828-9 |n 2 |q 65:2<231 - 249 |p 231-249 |t Glia |v 65 |y 2016 |x 0894-1491 |
| 909 | C | O | |o oai:pub.dzne.de:139027 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2811203 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 6 |6 P:(DE-2719)2259138 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |2 G:(DE-HGF)POF3-300 |v Molecular Signaling |x 0 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-08 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-08 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b GLIA : 2021 |d 2022-11-08 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b GLIA : 2021 |d 2022-11-08 |
| 920 | 1 | _ | |0 I:(DE-2719)1013012 |k AG Alamoudi |l Cryo-electron microscopy and tomography |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1013012 |
| 980 | _ | _ | |a UNRESTRICTED |
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