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@ARTICLE{Lacour:139044,
      author       = {Lacour, Andre and Espinosa, A. and Louwersheimer, E. and
                      Heilmann, S. and Hernández, I. and Wolfsgruber, S. and
                      Fernández, V. and Wagner, H. and Rosende-Roca, M. and
                      Mauleón, A. and Moreno-Grau, S. and Vargas, L. and
                      Pijnenburg, Y. A. L. and Koene, T. and Rodríguez-Gómez, O.
                      and Ortega, G. and Ruiz, S. and Holstege, H. and
                      Sotolongo-Grau, O. and Kornhuber, J. and Peters, O. and
                      Frölich, L. and Hüll, M. and Rüther, E. and Wiltfang, J.
                      and Scherer, M. and Riedel-Heller, S. and Alegret, M. and
                      Nöthen, M. M. and Scheltens, P. and Tárraga, L. and
                      Jessen, F. and Boada, M. and Maier, W. and van der Flier, W.
                      M. and Becker, T. and Ramirez, A. and Ruiz, A.},
      title        = {{G}enome-wide significant risk factors for {A}lzheimer's
                      disease: role in progression to dementia due to
                      {A}lzheimer's disease among subjects with mild cognitive
                      impairment.},
      journal      = {Molecular psychiatry},
      volume       = {22},
      number       = {1},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {DZNE-2020-05366},
      pages        = {153-160},
      year         = {2017},
      abstract     = {Few data are available concerning the role of risk markers
                      for Alzheimer's disease (AD) in progression to AD dementia
                      among subjects with mild cognitive impairment (MCI). We
                      therefore investigated the role of well-known AD-associated
                      single-nucleotide polymorphism (SNP) in the progression from
                      MCI to AD dementia. Four independent MCI data sets were
                      included in the analysis: (a) the German study on Aging,
                      Cognition and Dementia in primary care patients (n=853); (b)
                      the German Dementia Competence Network (n=812); (c) the
                      Fundació ACE from Barcelona, Spain (n=1245); and (d) the
                      MCI data set of the Amsterdam Dementia Cohort (n=306). The
                      effects of single markers and combined polygenic scores were
                      measured using Cox proportional hazards models and
                      meta-analyses. The clusterin (CLU) locus was an independent
                      genetic risk factor for MCI to AD progression (CLU
                      rs9331888: hazard ratio (HR)=1.187 (1.054-1.32); P=0.0035).
                      A polygenic score (PGS1) comprising nine established
                      genome-wide AD risk loci predicted a small effect on the
                      risk of MCI to AD progression in APOE-ɛ4 (apolipoprotein
                      E-ɛ4) carriers (HR=1.746 (1.029-2.965); P=0.038). The novel
                      AD loci reported by the International Genomics of
                      Alzheimer's Project were not implicated in MCI to AD
                      dementia progression. SNP-based polygenic risk scores
                      comprising currently available AD genetic markers did not
                      predict MCI to AD progression. We conclude that SNPs in CLU
                      are potential markers for MCI to AD progression.},
      keywords     = {Aged / Aged, 80 and over / Alzheimer Disease: genetics /
                      Apolipoprotein E4: genetics / Biomarkers / Clusterin:
                      genetics / Cognitive Dysfunction: genetics / Dementia:
                      genetics / Disease Progression / Female / Follow-Up Studies
                      / Genetic Predisposition to Disease / Genome-Wide
                      Association Study: methods / Humans / Male / Middle Aged /
                      Polymorphism, Single Nucleotide: genetics / Risk Factors /
                      Apolipoprotein E4 (NLM Chemicals) / Biomarkers (NLM
                      Chemicals) / CLU protein, human (NLM Chemicals) / Clusterin
                      (NLM Chemicals)},
      cin          = {AG Becker / AG Wagner / AG Jessen / U Clinical Researchers
                      - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)1013007 / I:(DE-2719)1011201 /
                      I:(DE-2719)1011102 / I:(DE-2719)7000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26976043},
      pmc          = {pmc:PMC5414086},
      doi          = {10.1038/mp.2016.18},
      url          = {https://pub.dzne.de/record/139044},
}