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000139073 0247_ $$2doi$$a10.3233/JAD-160854
000139073 0247_ $$2pmid$$apmid:28106551
000139073 0247_ $$2ISSN$$a1387-2877
000139073 0247_ $$2ISSN$$a1875-8908
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000139073 037__ $$aDZNE-2020-05395
000139073 041__ $$aEnglish
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000139073 1001_ $$0P:(DE-2719)9001109$$aKunz, Lukas$$b0$$eFirst author$$udzne
000139073 245__ $$aConscientiousness is Negatively Associated with Grey Matter Volume in Young APOE ɛ4-Carriers.
000139073 260__ $$aAmsterdam$$bIOS Press$$c2017
000139073 264_1 $$2Crossref$$3print$$bIOS Press$$c2017-02-03
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000139073 520__ $$aThe etiology of late onset Alzheimer's disease (LOAD) depends on multiple factors, among which the APOE ɛ4 allele is the most adverse genetic determinant and conscientiousness represents an influential personality trait. A potential association of both factors with brain structure in young adulthood may constitute a constellation that sets the course toward or against the subtle disease progression of LOAD that starts decades before clinical manifestation. Hence, in the present study, we examined the modulating effects of APOE ɛ4 on the relation between personality dimensions, including conscientiousness, and total grey matter volume (GMV) in young healthy adults using an a priori genotyping design. 105 participants completed an inventory assessing the Five Factor Model of Personality (NEO-FFI) and a structural MRI scan. Total GMV was estimated using both Freesurfer as well as VBM8. Across all participants, total GMV was positively associated with extraversion and negatively related to age. In APOE ɛ4-carriers- but not in APOE ɛ4-non-carriers- conscientiousness was negatively associated with total GMV. In line with the hypothesis of antagonistic pleiotropy of the APOE ɛ4 allele, this result suggests that young APOE ɛ4-carriers with increased total GMV may particularly benefit from cognitive advantages and thus have a lower need to engage in conscientious behavior. In this subset of young APOE ɛ4-carriers, the reduction in conscientiousness could then bring along adverse health behavior in the long run, potentiating the risk for LOAD. Hence, young APOE ɛ4-carriers with increased total GMV may be at a particularly high risk for LOAD.
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000139073 650_7 $$2NLM Chemicals$$aApolipoprotein E3
000139073 650_7 $$2NLM Chemicals$$aApolipoprotein E4
000139073 650_2 $$2MeSH$$aApolipoprotein E3: genetics
000139073 650_2 $$2MeSH$$aApolipoprotein E4: genetics
000139073 650_2 $$2MeSH$$aBrain: diagnostic imaging
000139073 650_2 $$2MeSH$$aFemale
000139073 650_2 $$2MeSH$$aGenotyping Techniques
000139073 650_2 $$2MeSH$$aGray Matter: diagnostic imaging
000139073 650_2 $$2MeSH$$aHeterozygote
000139073 650_2 $$2MeSH$$aHumans
000139073 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000139073 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000139073 650_2 $$2MeSH$$aMale
000139073 650_2 $$2MeSH$$aMultivariate Analysis
000139073 650_2 $$2MeSH$$aOrgan Size
000139073 650_2 $$2MeSH$$aPersonality: genetics
000139073 650_2 $$2MeSH$$aSelf Report
000139073 650_2 $$2MeSH$$aYoung Adult
000139073 7001_ $$0P:(DE-HGF)0$$aReuter, Martin$$b1
000139073 7001_ $$0P:(DE-2719)2000052$$aAxmacher, Nikolai$$b2
000139073 7001_ $$0P:(DE-HGF)0$$aMontag, Christian$$b3
000139073 77318 $$2Crossref$$3journal-article$$a10.3233/jad-160854$$b : IOS Press, 2017-02-03$$n3$$p1135-1144$$tJournal of Alzheimer's Disease$$v56$$x1387-2877$$y2017
000139073 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-160854$$gVol. 56, no. 3, p. 1135 - 1144$$n3$$p1135-1144$$q56:3<1135 - 1144$$tJournal of Alzheimer's disease$$v56$$x1387-2877$$y2017
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000139073 9141_ $$y2017
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