Home > Publications Database > Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. > print

001     139113
005     20240321220546.0
024 7 _ |a 2211-1247
|2 ISSN
024 7 _ |a 10.1016/j.celrep.2016.12.033
|2 doi
024 7 _ |a pmid:28076789
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024 7 _ |a pmc:PMC5263236
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024 7 _ |a altmetric:15414037
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024 7 _ |a 2639-1856
|2 ISSN
037 _ _ |a DZNE-2020-05435
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lechler, Marie C
|0 P:(DE-2719)2810617
|b 0
|e First author
|u dzne
245 _ _ |a Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.
260 _ _ |a [New York, NY]
|c 2017
|b Elsevier
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2017-01-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
|b journal
|m journal
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|s 1710340500_30568
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
|0 0
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520 _ _ |a Low-complexity 'prion-like' domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized, it remains unknown how the process of aging disturbs RBP dynamics. We show that a wide variety of RNA granule components, including stress granule proteins, become highly insoluble with age in C. elegans and that reduced insulin/insulin-like growth factor 1 (IGF-1) daf-2 receptor signaling efficiently prevents their aggregation. Importantly, stress-granule-related RBP aggregates are associated with reduced fitness. We show that heat shock transcription factor 1 (HSF-1) is a main regulator of stress-granule-related RBP aggregation in both young and aged animals. During aging, increasing DAF-16 activity restores dynamic stress-granule-related RBPs, partly by decreasing the buildup of other misfolded proteins that seed RBP aggregation. Longevity-associated mechanisms found to maintain dynamic RBPs during aging could be relevant for neurodegenerative diseases.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
542 _ _ |i 2017-01-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2016-12-13
|2 Crossref
|u http://creativecommons.org/licenses/by-nc-nd/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Caenorhabditis elegans Proteins
|2 NLM Chemicals
650 _ 7 |a Heat-Shock Proteins
|2 NLM Chemicals
650 _ 7 |a Insulin
|2 NLM Chemicals
650 _ 7 |a Protein Aggregates
|2 NLM Chemicals
650 _ 7 |a RNA-Binding Proteins
|2 NLM Chemicals
650 _ 7 |a RNA
|0 63231-63-0
|2 NLM Chemicals
650 _ 7 |a Insulin-Like Growth Factor I
|0 67763-96-6
|2 NLM Chemicals
650 _ 7 |a DAF-2 protein, C elegans
|0 EC 2.7.10.1
|2 NLM Chemicals
650 _ 7 |a Receptor, Insulin
|0 EC 2.7.10.1
|2 NLM Chemicals
650 _ 2 |a Aging: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Caenorhabditis elegans: metabolism
|2 MeSH
650 _ 2 |a Caenorhabditis elegans Proteins: metabolism
|2 MeSH
650 _ 2 |a Cytoplasmic Granules: metabolism
|2 MeSH
650 _ 2 |a Heat-Shock Proteins: metabolism
|2 MeSH
650 _ 2 |a Insulin: metabolism
|2 MeSH
650 _ 2 |a Insulin-Like Growth Factor I: metabolism
|2 MeSH
650 _ 2 |a Longevity
|2 MeSH
650 _ 2 |a Mutation: genetics
|2 MeSH
650 _ 2 |a Protein Aggregates
|2 MeSH
650 _ 2 |a RNA: metabolism
|2 MeSH
650 _ 2 |a RNA-Binding Proteins: metabolism
|2 MeSH
650 _ 2 |a Receptor, Insulin: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
650 _ 2 |a Solubility
|2 MeSH
700 1 _ |a Crawford, Emily D
|0 P:(DE-2719)2810675
|b 1
|u dzne
700 1 _ |a Groh, Nicole
|0 P:(DE-2719)2811001
|b 2
|u dzne
700 1 _ |a Widmaier, Katja
|0 P:(DE-2719)2810812
|b 3
|u dzne
700 1 _ |a Jung, Raimund
|0 P:(DE-2719)2811479
|b 4
|u dzne
700 1 _ |a Kirstein, Janine
|b 5
700 1 _ |a Trinidad, Jonathan C
|b 6
700 1 _ |a Burlingame, Alma L
|b 7
700 1 _ |a David, Della
|0 P:(DE-2719)2810353
|b 8
|e Last author
|u dzne
773 1 8 |a 10.1016/j.celrep.2016.12.033
|b : Elsevier BV, 2017-01-01
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|t Cell Reports
|v 18
|y 2017
|x 2211-1247
773 _ _ |a 10.1016/j.celrep.2016.12.033
|g Vol. 18, no. 2, p. 454 - 467
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856 4 _ |y OpenAccess
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856 7 _ |2 Pubmed Central
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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