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000139122 0247_ $$2doi$$a10.1177/1533317516678087
000139122 0247_ $$2pmid$$apmid:28100076
000139122 0247_ $$2ISSN$$a0895-5336
000139122 0247_ $$2ISSN$$a1082-5207
000139122 0247_ $$2ISSN$$a1533-3175
000139122 0247_ $$2ISSN$$a1938-2731
000139122 037__ $$aDZNE-2020-05444
000139122 041__ $$aEnglish
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000139122 1001_ $$0P:(DE-HGF)0$$aHaussmann, Robert$$b0
000139122 245__ $$aPrecuneus Structure Changes in Amnestic Mild Cognitive Impairment.
000139122 260__ $$aThousand Oaks, Calif.$$bSage$$c2017
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000139122 520__ $$aPatients with amnestic mild cognitive impairment (aMCI) are at risk for developing Alzheimer's disease. Due to their prominent memory impairment, structural magnetic resonance imaging (MRI) often focuses on the hippocampal region. However, recent positron-emission tomography data suggest that within a network of frontal and temporal changes, patients with aMCI show metabolic alterations in the precuneus, a key region for higher cognitive functions. Using high-resolution MRI and whole-brain cortical thickness analyses in 28 patients with aMCI and 25 healthy individuals, we wanted to investigate whether structural changes in the precuneus would be associated with cortical thickness reductions in frontal and temporal brain regions in patients with aMCI. In contrast to healthy people, patients with aMCI showed an association of cortical thinning in the precuneus with predominantly left-hemispheric thickness reductions in medial temporal and frontal cortices. Our data highlight structural neuronal network characteristics among patients with aMCI.
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000139122 650_2 $$2MeSH$$aAged
000139122 650_2 $$2MeSH$$aAged, 80 and over
000139122 650_2 $$2MeSH$$aAmnesia: pathology
000139122 650_2 $$2MeSH$$aCerebral Cortex: pathology
000139122 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000139122 650_2 $$2MeSH$$aFemale
000139122 650_2 $$2MeSH$$aHumans
000139122 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000139122 650_2 $$2MeSH$$aMale
000139122 650_2 $$2MeSH$$aMiddle Aged
000139122 650_2 $$2MeSH$$aParietal Lobe: pathology
000139122 7001_ $$0P:(DE-HGF)0$$aWerner, Annett$$b1
000139122 7001_ $$aGruschwitz, Antonia$$b2
000139122 7001_ $$0P:(DE-2719)2810905$$aOsterrath, Antje$$b3$$udzne
000139122 7001_ $$aLange, Jan$$b4
000139122 7001_ $$aDonix, Katharina L$$b5
000139122 7001_ $$aLinn, Jennifer$$b6
000139122 7001_ $$0P:(DE-2719)2501739$$aDonix, Markus$$b7$$eLast author$$udzne
000139122 77318 $$2Crossref$$3journal-article$$a10.1177/1533317516678087$$b : SAGE Publications, 2016-11-15$$n1$$p22-26$$tAmerican Journal of Alzheimer's Disease & Other Dementiasr$$v32$$x1533-3175$$y2016
000139122 773__ $$0PERI:(DE-600)2235173-5$$a10.1177/1533317516678087$$gVol. 32, no. 1, p. 22 - 26$$n1$$p22-26$$q32:1<22 - 26$$tAmerican journal of Alzheimer's disease and other dementias$$v32$$x1533-3175$$y2017
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